Sara Alaei
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View article: Epigenomics and transcriptomics profiles of developing zebrafish heart cells
Epigenomics and transcriptomics profiles of developing zebrafish heart cells Open
cis -Regulatory elements (cREs) are essential for the spatio-temporal control of gene expression during development and disease. However, cRE activity is highly dependent on cell and tissue type. The developing heart is composed of several…
View article: Redundant and novel functions of scube genes during zebrafish development
Redundant and novel functions of scube genes during zebrafish development Open
The N-glycoprotein SCUBE family (Scube1, Scube2, and Scube3) plays diverse roles in vertebrate development and disease, yet many specific functions of the three family members remain unclear. These proteins exhibit broad tissue expression …
View article: Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer
Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer Open
View article: Systematic molecular profiling of acute leukemia cancer stem cells allows identification of druggable targets
Systematic molecular profiling of acute leukemia cancer stem cells allows identification of druggable targets Open
View article: FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy Open
View article: Cell Type of Origin Dictates the Route to Pluripotency
Cell Type of Origin Dictates the Route to Pluripotency Open
View article: Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming
Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming Open
View article: Cell Type of Origin Dictates the Route to Pluripotency
Cell Type of Origin Dictates the Route to Pluripotency Open
Our current understanding of induced pluripotent stem cell (iPSC) generation has almost entirely been shaped by studies performed on reprogramming fibroblasts. However, whether the resulting model universally applies to the reprogramming p…
View article: Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest
Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest Open
View article: Dynamics of transcription factor targeting and chromatin states during reprogramming
Dynamics of transcription factor targeting and chromatin states during reprogramming Open
Induced pluripotent stem cells (iPSCs) have been produced from a number of mouse and human somatic cell types, upon the enforced expression of the transcription factors (TFs) Oct4, Klf4, Sox2, and c-Myc (OKSM). Reprogramming leads to inact…
View article: An improved reprogrammable mouse model harbouring the reverse tetracycline-controlled transcriptional transactivator 3
An improved reprogrammable mouse model harbouring the reverse tetracycline-controlled transcriptional transactivator 3 Open
Reprogrammable mouse models engineered to conditionally express Oct-4, Klf-4, Sox-2 and c-Myc (OKSM) have been instrumental in dissecting molecular events underpinning the generation of induced pluripotent stem cells. However, until now th…