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View article: Cardiometabolic Candidate Endotypes in Psoriatic Disease: Integration of Clinical, Metabolic, and Immunogenetic Data Across Psoriasis and Psoriatic Arthritis
Cardiometabolic Candidate Endotypes in Psoriatic Disease: Integration of Clinical, Metabolic, and Immunogenetic Data Across Psoriasis and Psoriatic Arthritis Open
Background/objectives: Psoriatic disease (PsD) encompasses psoriasis (PsO) and psori-atic arthritis (PsA) and is associated with heterogeneous cardiometabolic risk. Inte-grating immunogenetic markers such as HLA-Cw6 into data-driven analys…
View article: Incidence and molecular underpinnings of donor-cell derived neoplasm among spanish transplantation centers
Incidence and molecular underpinnings of donor-cell derived neoplasm among spanish transplantation centers Open
Introduction After an allogeneic hematopoietic stem cell transplantation (allo-HSCT), a wide range of complications may occur. One of the less common, yet clinically significant, is the development of a donor-cell derived hematologic neopl…
View article: Tailoring Inflammatory Biomarker Assessment in Axial Spondyloarthritis: A Comparative Study of Erythrocyte Sedimentation Rate and C-Reactive Protein Across Disease Profiles
Tailoring Inflammatory Biomarker Assessment in Axial Spondyloarthritis: A Comparative Study of Erythrocyte Sedimentation Rate and C-Reactive Protein Across Disease Profiles Open
Background: Personalized medicine in axial spondyloarthritis (axSpA) requires accurate tools to assess inflammation and tailor disease monitoring. The role of traditional biomarkers such as erythrocyte sedimentation rate (ESR) and C-reacti…
View article: Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Open
View article: 678 | IMMUNE DYSREGULATION IN DIFFUSE LARGE B‐CELL LYMPHOMA/HIGH‐GRADE B‐CELL LYMPHOMA WITH MYC ALTERATIONS: COMPARATIVE ANALYSIS OF R‐CHOP VERSUS R‐DA‐EPOCH
678 | IMMUNE DYSREGULATION IN DIFFUSE LARGE B‐CELL LYMPHOMA/HIGH‐GRADE B‐CELL LYMPHOMA WITH MYC ALTERATIONS: COMPARATIVE ANALYSIS OF R‐CHOP VERSUS R‐DA‐EPOCH Open
View article: 492 | PSEUDO‐DOUBLE‐HIT LARGE B‐CELL LYMPHOMAS: ARE MYC AND BCL6 MARRIED?
492 | PSEUDO‐DOUBLE‐HIT LARGE B‐CELL LYMPHOMAS: ARE MYC AND BCL6 MARRIED? Open
View article: Flexible‐tip bougie vs. stylet for tracheal intubation with a hyperangulated videolaryngoscope in critical care: a randomised controlled trial
Flexible‐tip bougie vs. stylet for tracheal intubation with a hyperangulated videolaryngoscope in critical care: a randomised controlled trial Open
Summary Introduction The optimal introducer for tracheal intubation with a hyperangulated blade videolaryngoscope for patients in the ICU remains uncertain. Both stylets and flexible‐tip bougies have been used, yet there is limited evidenc…
View article: Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Open
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferative γδ IEL (γδ HYP ) phenotype also upr…
View article: Prevalence and Structural Damage-Associated Factors in Psoriatic Arthritis: A Real-Life Study in the Era of Advanced Therapies
Prevalence and Structural Damage-Associated Factors in Psoriatic Arthritis: A Real-Life Study in the Era of Advanced Therapies Open
View article: Characterisation of specific responses to three models of viral antigens in immunocompetent older adults
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults Open
The results indicate that memory responses differ depending on the durability of the antigen stimulus. Cellular responses to novel pathogens resemble those generated by seasonal but not CMV infection. Subpopulation distribution and the lev…
View article: Searching for a Novel HLA-Cw6-Linked Cardiometabolic Endotype in Psoriatic Disease
Searching for a Novel HLA-Cw6-Linked Cardiometabolic Endotype in Psoriatic Disease Open
Background/Objectives: In recent years, a possible connection between HLA-Cw6 and a distinctive cardiometabolic (CM) profile in patients with psoriatic disease (PsD) has been proposed, although there is still little support for this. Our a…
View article: Intramuscular hemangioma of the infraspinatus muscle: a rare presentation
Intramuscular hemangioma of the infraspinatus muscle: a rare presentation Open
Intramuscular hemangiomas (IMH) are extremely rare, accounting for 0.8% of all hemangiomas. IMH must be included in the differential diagnosis of soft tissue masses, and unexplained muscular pain. We herein describe the case of a patient w…
View article: Characterization of Specific Responses to Three Models of Viral Antigens in Immunocompetent Older Adults
Characterization of Specific Responses to Three Models of Viral Antigens in Immunocompetent Older Adults Open
Background Memory responses to the antigens that an individual encounters throughout life may vary with the intensity and duration of antigen contacts or even changes in immune status over time. This work aims to characterise specific resp…
View article: Impact of universal use of a hyperangulated videolaryngoscope as the first option for all intubations in the ICU: A prospective before-after study
Impact of universal use of a hyperangulated videolaryngoscope as the first option for all intubations in the ICU: A prospective before-after study Open
View article: Central carbon metabolism exhibits unique characteristics during the handling of fungal patterns by monocyte-derived dendritic cells
Central carbon metabolism exhibits unique characteristics during the handling of fungal patterns by monocyte-derived dendritic cells Open
Monocyte-derived dendritic cells (MDDCs) are key players in the defense against fungal infection because of their outstanding capacity for non-opsonic phagocytosis and phenotypic plasticity. Accordingly, MDDCs rewire metabolism to meet the…
View article: The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection
The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection Open
View article: Baseline immunophenotypic profile of bone marrow leukemia cells in acute myeloid leukemia with nucleophosmin-1 gene mutation: a EuroFlow study
Baseline immunophenotypic profile of bone marrow leukemia cells in acute myeloid leukemia with nucleophosmin-1 gene mutation: a EuroFlow study Open
View article: Expansion of the intraepithelial lymphocyte (IEL) compartment results in an increased bioenergetic profile and reduced IFNγ production in γδ IELs
Expansion of the intraepithelial lymphocyte (IEL) compartment results in an increased bioenergetic profile and reduced IFNγ production in γδ IELs Open
Intestinal γδ intraepithelial lymphocytes (γδ IEL) serve as the first line of defense against pathogen invasion. We recently identified a transmissible hyperproliferative γδ IEL (γδHYP) phenotype that protects against enteric infection, an…
View article: Supplementary Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Supplementary Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
Methods, Supplemental Figs 1-7
View article: EV real time image from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
EV real time image from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
Shows EVs moving inside the cell
View article: Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
In the bone marrow (BM), breast cancer cells (BCC) can survive in dormancy for decades as cancer stem cells (CSC), resurging as tertiary metastasis. The endosteal region where BCCs exist as CSCs poses a challenge to target them, mostly due…
View article: Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
In the bone marrow (BM), breast cancer cells (BCC) can survive in dormancy for decades as cancer stem cells (CSC), resurging as tertiary metastasis. The endosteal region where BCCs exist as CSCs poses a challenge to target them, mostly due…
View article: Supplementary Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
Supplementary Data from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
Methods, Supplemental Figs 1-7
View article: EV real time image from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region
EV real time image from Mesenchymal Stem Cell–Secreted Extracellular Vesicles Instruct Stepwise Dedifferentiation of Breast Cancer Cells into Dormancy at the Bone Marrow Perivascular Region Open
Shows EVs moving inside the cell
View article: Metabolic regulation of γδ intraepithelial lymphocytes
Metabolic regulation of γδ intraepithelial lymphocytes Open
Elucidating the relationship between cellular metabolism and T cell function has substantially advanced our understanding of how T cells are regulated in response to activation. The metabolic profiles of circulating or peripheral T cells h…
View article: Mapping the genetic features of T-ALL cases through simplified NGS approach
Mapping the genetic features of T-ALL cases through simplified NGS approach Open
HTS is a useful approach that allows simultaneously analyzing mutations, CNVs and the clonal repertoire in T-ALL patients. This approach may simplify the genetic assessment of ALL.
View article: Non-Physical Disease Facets in Spondyloarthritis: An ASAS Health Index-Based Analysis between Psoriatic Arthritis and Axial Spondyloarthritis
Non-Physical Disease Facets in Spondyloarthritis: An ASAS Health Index-Based Analysis between Psoriatic Arthritis and Axial Spondyloarthritis Open
Background: Psychosocial health is a key driver of quality of life (QoL) in axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), but it is often overlooked in clinical practice. We aimed to analyze this aspect of QoL by using the…
View article: Optical Genome Mapping: A Promising New Tool to Assess Genomic Complexity in Chronic Lymphocytic Leukemia (CLL)
Optical Genome Mapping: A Promising New Tool to Assess Genomic Complexity in Chronic Lymphocytic Leukemia (CLL) Open
Novel treatments in chronic lymphocytic leukemia (CLL) have generated interest regarding the clinical impact of genomic complexity, currently assessed by chromosome banding analysis (CBA) and chromosomal microarray analysis (CMA). Optical …
View article: A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection
A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection Open
View article: IRE1α-XBP1 Activation Elicited by Viral Singled Stranded RNA via <i>TLR8</i> May Modulate Lung Cytokine Induction in SARS-CoV-2 Pneumonia
IRE1α-XBP1 Activation Elicited by Viral Singled Stranded RNA via <i>TLR8</i> May Modulate Lung Cytokine Induction in SARS-CoV-2 Pneumonia Open
Initial symptoms of COVID-19 infection depend on viral replication, while hyperinflammation is a hallmark of critical illness and may drive severe pneumonia and death. Among the mechanisms potentially involved in the hyperinflammatory stat…