Sara Baratchi
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View article: Recent advances in bioactive wound dressings
Recent advances in bioactive wound dressings Open
Traditional wound dressings, despite their widespread use, face limitations, such as poor infection control and insufficient healing promotion. To address these challenges, bioactive materials have emerged as a promising solution in wound …
View article: Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation
Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation Open
BACKGROUND: CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and proinflammat…
View article: Piezo1 expression in neutrophils regulates shear-induced NETosis
Piezo1 expression in neutrophils regulates shear-induced NETosis Open
Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets …
View article: <b>The role of activator protein-1 (AP-1) complex in diabetes associated atherosclerosis: Insights from single cell RNA sequencing</b>
<b>The role of activator protein-1 (AP-1) complex in diabetes associated atherosclerosis: Insights from single cell RNA sequencing</b> Open
AbstractDespite advances in the treatment of atherosclerotic cardiovascular disease, it remains the leading cause of death in patients with diabetes. Even when risk factors are mitigated, the disease progresses, and thus newer targets need…
View article: <b>The role of activator protein-1 (AP-1) complex in diabetes associated atherosclerosis: Insights from single cell RNA sequencing</b>
<b>The role of activator protein-1 (AP-1) complex in diabetes associated atherosclerosis: Insights from single cell RNA sequencing</b> Open
AbstractDespite advances in the treatment of atherosclerotic cardiovascular disease, it remains the leading cause of death in patients with diabetes. Even when risk factors are mitigated, the disease progresses, and thus newer targets need…
View article: Tube Oscillation Drives Transitory Vortices Across Microfluidic Barriers
Tube Oscillation Drives Transitory Vortices Across Microfluidic Barriers Open
Here, the generation of dynamic vortices across microscale barriers using the tube oscillation mechanism is demonstrated. Using a combination of high‐speed imaging and computational flow dynamics, the cyclic formation, expansion, and colla…
View article: A 3D printed flow sensor for microfluidic applications
A 3D printed flow sensor for microfluidic applications Open
Here, we describe the development and characterisation of a flow sensor for microfluidic applications. The flow sensor utilises two miniaturised commercial pressure sensors mounted across a 3D printed microfluidic tube to measure the flow …
View article: Editorial: Innovative approaches in drug discovery and development
Editorial: Innovative approaches in drug discovery and development Open
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View article: Label-free macrophage phenotype classification using machine learning methods
Label-free macrophage phenotype classification using machine learning methods Open
Macrophages are heterogeneous innate immune cells that are functionally shaped by their surrounding microenvironment. Diverse macrophage populations have multifaceted differences related to their morphology, metabolism, expressed markers, …
View article: A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein Open
C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relat…
View article: Label-free Macrophage Phenotype Classification Using Machine Learning Methods
Label-free Macrophage Phenotype Classification Using Machine Learning Methods Open
Macrophages are heterogeneous innate immune cells that are functionally shaped by their surrounding microenvironment. Diverse macrophage populations have multifaceted differences related to their morphology, metabolism, expressed markers, …
View article: Uncoupling the Vicious Cycle of Mechanical Stress and Inflammation in Calcific Aortic Valve Disease
Uncoupling the Vicious Cycle of Mechanical Stress and Inflammation in Calcific Aortic Valve Disease Open
Calcific aortic valve disease (CAVD) is a common acquired valvulopathy, which carries a high burden of mortality. Chronic inflammation has been postulated as the predominant pathophysiological process underlying CAVD. So far, no effective …
View article: Studying the Mechanobiology of Aortic Endothelial Cells Under Cyclic Stretch Using a Modular 3D Printed System
Studying the Mechanobiology of Aortic Endothelial Cells Under Cyclic Stretch Using a Modular 3D Printed System Open
Here, we describe a motorized cam-driven system for the cyclic stretch of aortic endothelial cells. Our modular design allows for generating customized spatiotemporal stretch profiles by varying the profile and size of 3D printed cam and f…
View article: Mechanosensing by Piezo1 and its implications for physiology and various pathologies
Mechanosensing by Piezo1 and its implications for physiology and various pathologies Open
Piezo1 is a mechanosensitive ion channel with essential roles in cardiovascular, lung, urinary, and immune functions. Piezo1 is widely distributed in different tissues in the human body and its specific roles have been identified following…
View article: Evaluation of in vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities
Evaluation of in vitro human skin models for studying effects of external stressors and stimuli and developing treatment modalities Open
Skin is exposed to a variety of potential stressors and stimulators that may impact homeostasis, healing, tumor development, inflammation, and irritation. As such it is important to understand the impact that these stimuli have on skin hea…
View article: Tunable Harmonic Flow Patterns in Microfluidic Systems through Simple Tube Oscillation
Tunable Harmonic Flow Patterns in Microfluidic Systems through Simple Tube Oscillation Open
Generation of tunable harmonic flows at low cost in microfluidic systems is a persistent and significant obstacle to this field, substantially limiting its potential to address major scientific questions and applications. This work introdu…
View article: Transcatheter Aortic Valve Implantation Represents an Anti-Inflammatory Therapy Via Reduction of Shear Stress–Induced, Piezo-1–Mediated Monocyte Activation
Transcatheter Aortic Valve Implantation Represents an Anti-Inflammatory Therapy Via Reduction of Shear Stress–Induced, Piezo-1–Mediated Monocyte Activation Open
Background: Aortic valve stenosis is an increasingly prevalent degenerative and inflammatory disease. Transcatheter aortic valve implantation (TAVI) has revolutionized its treatment, thereby avoiding its life-threatening/disabling conseque…
View article: Editorial: Mechanobiology: Emerging Tools and Methods
Editorial: Mechanobiology: Emerging Tools and Methods Open
EDITORIAL article Front. Bioeng. Biotechnol., 09 April 2020 | https://doi.org/10.3389/fbioe.2020.00289
View article: A Microfluidic System for Studying the Effects of Disturbed Flow on Endothelial Cells
A Microfluidic System for Studying the Effects of Disturbed Flow on Endothelial Cells Open
Arterial endothelium experience physical stress associated with blood flow and play a central role in maintaining vascular integrity and homeostasis in response to hemodynamic forces. Blood flow within vessels is generally laminar and stre…
View article: Water Jacket Systems for Temperature Control of Petri Dish Cell Culture Chambers
Water Jacket Systems for Temperature Control of Petri Dish Cell Culture Chambers Open
Water jacket systems are routinely used to control the temperature of Petri dish cell culture chambers. Despite their widespread use, the thermal characteristics of such systems have not been fully investigated. In this study, we conducted…
View article: The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels
The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels Open
TRPV4 is a non-selective cation channel that tunes the function of different tissues including the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective and potent agonist of TRPV4 and a pharmacological tool t…
View article: Correction: Survivin Mutant Protects Differentiated Dopaminergic SK-N-SH Cells Against Oxidative Stress
Correction: Survivin Mutant Protects Differentiated Dopaminergic SK-N-SH Cells Against Oxidative Stress Open
Correction: Survivin Mutant Protects Differentiated Dopaminergic SK-N-SH Cells Against Oxidative Stress
View article: Shear Stress Regulates TRPV4 Channel Clustering and Translocation from Adherens Junctions to the Basal Membrane
Shear Stress Regulates TRPV4 Channel Clustering and Translocation from Adherens Junctions to the Basal Membrane Open
Localized Ca 2+ influx via TRPV4 on the surface of endothelial cells greatly influences endothelial adaptation to blood flow, but how mechanical stress from blood flow controls TRPV4 integration into this physiological function is not full…