Sara Bitarafan
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View article: Identification of Novel Kv1.3 Channel-Interacting Proteins Using Proximity Labelling in T-Cells
Identification of Novel Kv1.3 Channel-Interacting Proteins Using Proximity Labelling in T-Cells Open
Background/Aims: Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells. The voltage-activated Kv1.3 channel is an important regulator of T cell-mediated…
View article: Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelination
Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelination Open
Summary The extensive heterogeneity of microglia inflammatory states accompanying neurodegenerative diseases underscores the complex molecular mechanisms that regulate these cells. Here, we report on transcriptional mechanisms that control…
View article: Sensory neurostimulation promotes stress resilience with frequency-specificity
Sensory neurostimulation promotes stress resilience with frequency-specificity Open
Chronic stress is a major risk factor for neuropsychiatric disorders, acting via increased neuroinflammation and disrupted synaptic plasticity. While non-invasive visual or audiovisual neurostimulation (AV flicker) at 40Hz has been shown t…
View article: Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice
Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice Open
Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a comprehensive picture of the effects of this stimulation on multiple aspects of …
View article: Identification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells
Identification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells Open
Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells. The voltage-activated Kv1.3 channel is an important regulator of T cell-mediated autoimmunity and…
View article: Non‐invasive Flicker Neurostimulation Mitigates Stress Pathology in a Sex‐Dependent Manner
Non‐invasive Flicker Neurostimulation Mitigates Stress Pathology in a Sex‐Dependent Manner Open
Background Chronic stress promotes life‐long risk for neuropsychiatric decline by increasing neuroinflammation and disrupting synaptic health and plasticity. Our lab and others have recently demonstrated that non‐invasive gamma sensory sti…
View article: Non‐invasive Flicker Neurostimulation Mitigates Stress Pathology in a Sex‐Dependent Manner
Non‐invasive Flicker Neurostimulation Mitigates Stress Pathology in a Sex‐Dependent Manner Open
Background Chronic stress promotes life‐long risk for neuropsychiatric decline by increasing neuroinflammation and disrupting synaptic health and plasticity. Our lab and others have recently demonstrated that non‐invasive gamma sensory sti…
View article: Microglia morphological response to mesenchymal stromal cell extracellular vesicles demonstrates EV therapeutic potential for modulating neuroinflammation
Microglia morphological response to mesenchymal stromal cell extracellular vesicles demonstrates EV therapeutic potential for modulating neuroinflammation Open
View article: Microglia Morphological Response to Mesenchymal Stromal Cell Extracellular Vesicles Demonstrates EV Therapeutic Potential for Modulating Neuroinflammation
Microglia Morphological Response to Mesenchymal Stromal Cell Extracellular Vesicles Demonstrates EV Therapeutic Potential for Modulating Neuroinflammation Open
Background Mesenchymal stromal cell derived extracellular vesicles (MSC-EVs) are a promising therapeutic for neuroinflammation. MSC-EVs can interact with microglia, the resident immune cells of the brain, to exert their immunomodulatory ef…
View article: Frequency and duration of sensory flicker controls astrocyte and neuron specific transcriptional profiles in 5xFAD mice
Frequency and duration of sensory flicker controls astrocyte and neuron specific transcriptional profiles in 5xFAD mice Open
Background Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer’s disease, yet we lack a comprehensive picture of the effects of this stimulation on multiple aspect…
View article: Brain rhythms control microglial response and cytokine expression via NF-κB signaling
Brain rhythms control microglial response and cytokine expression via NF-κB signaling Open
Microglia transform in response to changes in sensory or neural activity, such as sensory deprivation. However, little is known about how specific frequencies of neural activity, or brain rhythms, affect microglia and cytokine signaling. U…
View article: Profiling the neuroimmune cascade in 3xTg mice exposed to successive mild traumatic brain injuries
Profiling the neuroimmune cascade in 3xTg mice exposed to successive mild traumatic brain injuries Open
Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology, amyloid beta (Aβ) plaques, gl…
View article: Repetitive mild traumatic brain injury induces hippocampal neural immune signaling linked to astrocyte reactivity
Repetitive mild traumatic brain injury induces hippocampal neural immune signaling linked to astrocyte reactivity Open
Background Repeated mild traumatic brain injuries (mTBIs) sustained within a “window of vulnerability” can lead to a cumulative severity of outcomes such as memory impairment, depression, and long‐term development of amyloid beta (Aβ) path…
View article: Systematic delineation of signaling and epigenomic mechanisms underlying microglia inflammatory activity in acute and chronic brain pathologies
Systematic delineation of signaling and epigenomic mechanisms underlying microglia inflammatory activity in acute and chronic brain pathologies Open
Microglia promptly mount an inflammatory response following detection of infectious agents or injuries in the central nervous system. Such function fundamentally depends upon dynamic modulation of gene expression. However, the signaling an…
View article: Modifiable Mesenchymal Stem Cell Defects in Veterans with Diabetes Mellitus
Modifiable Mesenchymal Stem Cell Defects in Veterans with Diabetes Mellitus Open
View article: Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease
Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease Open
Significance The potassium channel Kv1.3 in brain myeloid cells represents a promising therapeutic target for Alzheimer’s disease (AD). The patterns of expression and functional roles of Kv1.3 channels in brain myeloid subpopulations and t…
View article: Association of Increased Levels of lncRNA H19 in PBMCs with Risk of Coronary Artery Disease.
Association of Increased Levels of lncRNA H19 in PBMCs with Risk of Coronary Artery Disease. Open
We report here, the up-regulation of H19 lncRNA in the whole blood of CAD patients and suggest a possible role for H19 in the atherosclerosis process and its consideration as novel biomarker for CAD.
View article: Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease.
Association between Long Noncoding RNA ANRIL Expression Variants and Susceptibility to Coronary Artery Disease. Open
Animal cells possess thousands of long non-coding (lnc) RNAs, such as antisense noncoding RNA in the INK4 locus (ANRIL), which have regulatory roles in the cells' molecular mechanisms, including X-chromosome inactivation, and develo…