Sara Bottes
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Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus Open
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian hippocampus 1 . Advancing age leads to a decline in neurogenesis, which is associated with impaired cognition 2,3 . The cellular mechanisms causing reduced neur…
Live imaging of remyelination in the adult mouse corpus callosum Open
Significance Oligodendrocyte precursor cells (OPCs) retain the capacity to remyelinate axons upon demyelinating injury. However, mode of cell division and differentiation dynamics of individual OPCs in deep brain structures, such as the co…
<span>S</span>ox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of <span>B</span>ergmann glia Open
Sox2 is a transcription factor active in the nervous system, within different cell types, ranging from radial glia neural stem cells to a few specific types of differentiated glia and neurons. Mutations in the human SOX2 transcription fact…
Live imaging of neurogenesis in the adult mouse hippocampus Open
Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to …