Explanipedia

Recovering Immunogenic Orthohantavirus puumalaense N Protein from Pellets of Recombinant Escherichia coli Open

Natalya Andreeva, Е. В. Мартынова, Polina Elboeva, Milana Mansurova, И. И. Салафутдинов , et al. · 2025

(1) Background: Hemorrhagic fever with renal syndrome (HFRS) remains a prevalent zoonosis in Eurasia. Orthohantavirus puumalaense (PUUV), carried by bank voles (Myodes glareolus), is the principal zoonotic pathogen of HFRS in this region. …

RSV vaccines: The past, present and future Open

Sara Chandy, N. Divya, Anand Manoharan, Janani Sankar · 2025

Association between dengue and pediatric AUF: A study from Chennai and Kochi, South India Open

Sara Chandy, Divya Kindiyode Lakshmi Narayanan, Anand Manoharan, V. N. Moorthy, Gowridevi Vankayala , et al. · 2025

Background: Acute Undifferentiated Fever (AUF) is a common clinical presentation at hospitals in tropical and subtropical countries. Both children and adults present with this clinical condition which is difficult to diagnose clinically an…

Frequency and Clinical Outcomes of Respiratory Infections in Children with Cancer Presenting with Febrile Illness Open

Arathi Srinivasan, Renuka Sekar, Sara Chandy, Sundaram Balasubramanian · 2024

Objectives Fever is a known complication in pediatric cancer patients when on chemotherapy for which prompt initiation of empiric antibiotics is the single most important life-saving intervention. Nearly two-thirds of all children are trea…

Designing a Conserved Immunogenic Peptide Construct from the Nucleocapsid Protein of Puumala orthohantavirus Open

Ayushi Sehgal, Diksha Sharma, Neha Kaushal, Yogita Gupta, Ekaterina Martynova , et al. · 2024

Puumala orthohantavirus (PUUV) is an emerging zoonotic virus endemic to Europe and Russia that causes nephropathia epidemica, a mild form of hemorrhagic fever with renal syndrome (HFRS). There are limited options for treatment and diagnosi…

Evaluation of Real Time PCR Detection of the 47 kDa Gene for Reliable Diagnosis of Pediatric Scrub Typhus Open

Sara Chandy, Sudheer Kumar Peddi, M. Gurumoorthy, Hemalatha Ramachandran, Manoharan Ramya , et al. · 2024

Objective: Diagnosis of scrub typhus is difficult, because of its non-specific clinical features and a lack of reliable serological assays. This study assessed real time PCR detection of the 47 kDa gene along with routine IgM ELISA for con…

Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting Open

Sowmya Balasubramanian, Janani Sankar, K. Dhanalakshmi, Sibi Raj, Divya Nandakumar , et al. · 2023

Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention Open

Ayushi Sehgal, Sanya Mehta, Kritika Sahay, Ekaterina Martynova, Albert A. Rizvanov , et al. · 2023

Hemorrhagic Fever with Renal Syndrome (HFRS) is the most frequently diagnosed zoonosis in Asia. This zoonotic infection is the result of exposure to the virus-contaminated aerosols. Orthohantavirus infection may cause Hemorrhagic Fever wit…

Respiratory Syncytial Virus among Hospitalised Children in an Era of Pneumococcal Vaccination Open

Sara Chandy, Anand Manoharan, T. Subramanian, Sundaram Balasubramanian · 2023

Background: Acute respiratory tract infection (ARTI) is the leading cause of paediatric hospitalisations in India, especially ≤5 years of age. Aim: The study attempts to investigate RSV disease burden in the under-five and any association …

Clinical features and risk factors for death in acute undifferentiated fever: A prospective observational study in rural community hospitals in six states of India Open

Kristine Mørch, Anand Manoharan, Sara Chandy, Ashita Singh, Cijoy Kuriakose , et al. · 2022

Background Acute undifferentiated fever (AUF) ranges from self-limiting illness to life-threatening infections, such as sepsis, malaria, dengue, leptospirosis and rickettsioses. Similar clinical presentation challenges the clinical managem…

Evaluation of real-time PCR with serology for diagnosis of community acquired pneumonia caused by Mycoplasma pneumoniae Open

Anand Manoharan, M.S. Ramya, Sara Chandy, P.N. Ranjitha, Abdul Hameed , et al. · 2022

MIS-C Triggered by Omicron Variant of SARS-CoV-2 Open

Sundaram Balasubramanian, K. Dhanalakshmi, S. Lakshan Raj, Sara Chandy · 2022

A study on pediatric respiratory tract infections in hospitalised children from Chennai Open

Sara Chandy, Anand Manoharan, Abdul Hameed, Lionel Kumar Jones, Gothai S. Nachiyar , et al. · 2022

Globally, acute respiratory tract infections (ARTIs) are the leading cause of childhood morbidity and mortality. However, these infections remain poorly understood due to absence of affordable and effective diagnostic tools. In this study,…

Laboratory diagnosis of COVID-19 in secondary care hospitals in India: will standalone serology suffice? Open

Sara Chandy, Sundaram Balasubramanian, Anand Manoharan · 2021

Utility of a Multiplex Real-Time Polymerase Chain Reaction for Combined Detection and Serotyping of Dengue Virus in Paediatric Patients Hospitalised with Severe Dengue: A Report from Chennai Open

Sundaram Balasubramanian, Sara Chandy, Robinson Peter, Gothai S. Nachiyar, Amullya Sudhakar , et al. · 2020

Compared to NS1, multiplex real-time PCR is a rapid and accurate diagnostic test for children hospitalised with SD. DEN-2 was the predominant serotype in severe cases. Continued surveillance of serotypes should be carried out year-round in…

Nasopharyngeal carriage of Streptococcus pneumoniae serotypes among children in India prior to the introduction of pneumococcal conjugate vaccines: a cross-sectional study Open

Catherine G. Sutcliffe, Anita Shet, Rosemol Varghese, Balaji Veeraraghavan, Anand Manoharan , et al. · 2019

Prevalence of respiratory syncytial virus infection among children hospitalized with acute lower respiratory tract infections in Southern India Open

Sandesh Kini, Bhuvanesh Sukhlal Kalal, Sara Chandy, Ranjani Shamsundar, Anita Shet · 2019

Our study provides evidence of a high proportion of RSV and other virus-associated ALRI among hospitalized children in India. RSV infection was associated with fewer days of hospital stay compared to other causes of lower respiratory infec…

Correction: A High Malaria Prevalence Identified by PCR among Patients with Acute Undifferentiated Fever in India Open

Christel Gill Haanshuus, Sara Chandy, Anand Manoharan, Rosario Vivek, Dilip Mathai , et al. · 2018

[This corrects the article DOI: 10.1371/journal.pone.0158816.].

Genetic Diversity of Rotavirus Strains in the Era of Vaccination: A Pilot Study from Central Kerala, India Open

Sincy George, Ozhiparambil A Jagan, Sushama Bai, Sara Chandy · 2018

Introduction: Rotaviruses cause Acute Gastroenteritis (AGE) in children. Characterisation of rotavirus VP7, VP4 and VP6 genes revealed novel genotypes circulating in the region. Aim: To characterise the circulating rotavirus genotypes in C…

Molecular Diversity of Hepatitis B Virus X Gene in Central Kerala, Southern India Open

Ozhiparambil A Jagan, Manoj Gopi, N.S. Jayaprakash, Ramesh M Nair, Sara Chandy · 2018

Introduction: Hepatitis B Virus (HBV) causes diverse clinical manifestations ranging from acute fulminant Hepatitis, Chronic Hepatitis (CHB) to liver cirrhosis and Haepatocellular Carcinoma (HCC). The HBV X gene (HBV-X) is a 154 amino acid…

Acute undifferentiated fever in India: a multicentre study of aetiology and diagnostic accuracy Open

Kristine Mørch, Anand Manoharan, Sara Chandy, Novin Chacko, Gerardo Alvarez‐Uria , et al. · 2017

Malaria and dengue were the most common causes of fever in this study. A high overlap between case definitions probably reflects high prevalence of prior infections, cross reactivity and subclinical infections, rather than high prevalence …

Diagnostic potential of monoclonal antibodies developed against C-terminal polypeptide of <i>P. falciparum</i> Histidine Rich Protein2 (P<i>f</i>HRP2) in malaria infected patients from India Open

Reena Verma, Sara Chandy, N.S. Jayaprakash, Anand Manoharan, M.A. Vijayalakshmi , et al. · 2017

Malaria, caused by Plasmodium falciparum has become a major health burden in most tropical and developing countries. P. falciparum Histidine Rich Protein2 (PfHRP2), which exhibits polymorphism, is being widely used as a diagnostic marker. …

Globally Emerging Hantaviruses: An Overview Open

Sara Chandy, Dilip Mathai · 2017

Hantaviruses are known to cause haemorrhagic fever with renal syndrome in Eurasia and hantavirus cardiopulmonary syndrome in the Americas. They are globally emerging pathogens as newer serotypes are routinely being reported. This review di…

Serovar prevalence of Leptospira in semirural India and the development of an IgM-based indirect ELISA Open

Sara Chandy, Kirubanandhan Lokeshwaran, Priya Hemavathy, Anees Mohammad Khadeeja, Siby Kurian , et al. · 2017

Introduction: Leptospirosis is a major public health problem in India. However, it has been underreported and under-diagnosed due to a lack of awareness of the disease, a functional surveillance system, and appropriate laboratory diagnosti…

A High Malaria Prevalence Identified by PCR among Patients with Acute Undifferentiated Fever in India Open

Christel Gill Haanshuus, Sara Chandy, Anand Manoharan, Rosario Vivek, Dilip Mathai , et al. · 2016

[This corrects the article DOI: 10.1371/journal.pone.0158816.].

Molecular diversity of rotavirus strains from hospitalized children in Central Kerala Open

Sincy George, A J.O., Soumya Jes, Sushama Bai, Seema Oommen , et al. · 2016

Background: Group A Rotaviruses cause acute gastroenteritis (AGE) in children. In India, ∼ 500,000 children are hospitalized with AGE annually, with an estimated 100,000 deaths attributed to rotaviruses. This study was aimed to characteriz…

Molecular diversity of Hepatitis B virus (HBV) x gene: A preliminary report from Kerala Open

J. O A, Manoj Gopi, Jin S, G. Thomas K, Sara Chandy · 2016

Background: The HBV- x gene expresses a 154 aminoacid multifunctional protein widely associated with hepatocellular carcinoma in chronic patients. Genetic variability of the x gene may impact the differential oncogenic potential of HBV gen…

Molecular diversity of rotavirus strains from hospitalized children in Central Kerala Open

Sincy George, Jagan O.A, Soumya Jes, Sushama Bai, Seema Oommen , et al. · 2016

Molecular diversity of Hepatitis B virus (HBV) x gene: a preliminary report from Kerala Open

Ozhiparambil A Jagan, Manoj Gopi, Naatamani S Jayaprakash, George K Thomas, Sara Chandy · 2016

Role of 24-h ambulatory blood pressure monitoring in children with chronic kidney disease Open

Dulari Gupta, Swasti Chaturvedi, Sara Chandy, Indira Agarwal · 2015

Hypertension is common in children with chronic kidney disease (CKD) and is a major determinant of CKD progression. Ambulatory blood pressure monitoring (ABPM) has been proposed to be better in detecting hypertension as compared to casual …

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