Sara Corvigno
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View article: Epigenetic modulation of BARD1 to enhance anti-VEGF therapy
Epigenetic modulation of BARD1 to enhance anti-VEGF therapy Open
View article: Longitudinal genomic profiling of chemotherapy-related CHIP variants in patients with ovarian cancer
Longitudinal genomic profiling of chemotherapy-related CHIP variants in patients with ovarian cancer Open
Introduction Clonal hematopoiesis (CH) is characterized by the presence of hematopoietic stem cells (HSCs) with the potential of clonally expanding and giving rise to hematological malignancies. Clonal hematopoiesis of indeterminate potent…
View article: The dynamic immune behavior of primary and metastatic ovarian carcinoma
The dynamic immune behavior of primary and metastatic ovarian carcinoma Open
View article: High prevalence of FAP+ cancer-associated fibroblasts predicts poor outcome in patients with high-grade serous ovarian cancer with high CD8 T-cell density
High prevalence of FAP+ cancer-associated fibroblasts predicts poor outcome in patients with high-grade serous ovarian cancer with high CD8 T-cell density Open
The TME infiltration of FAP-positive fibroblasts is associated with poor prognosis in HGSC with high CD8+ cells density. Targeting the FAP+ subset of fibroblasts may unlock the local immune-activation in the TME thus enhance the positive p…
View article: Rapid Hyperspectral Photothermal Mid-Infrared Spectroscopic Imaging from Sparse Data for Gynecologic Cancer Tissue Subtyping
Rapid Hyperspectral Photothermal Mid-Infrared Spectroscopic Imaging from Sparse Data for Gynecologic Cancer Tissue Subtyping Open
Ovarian cancer detection has traditionally relied on a multi-step process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from severa…
View article: Enhanced plant-derived vesicles for nucleotide delivery for cancer therapy
Enhanced plant-derived vesicles for nucleotide delivery for cancer therapy Open
View article: Association between parity and pregnancy-associated tumor features in high-grade serous ovarian cancer
Association between parity and pregnancy-associated tumor features in high-grade serous ovarian cancer Open
View article: Angiogenesis‐Enabled Human Ovarian Tumor Microenvironment‐Chip Evaluates Pathophysiology of Platelets in Microcirculation
Angiogenesis‐Enabled Human Ovarian Tumor Microenvironment‐Chip Evaluates Pathophysiology of Platelets in Microcirculation Open
The tumor microenvironment (TME) promotes angiogenesis for its growth through the recruitment of multiple cells and signaling mechanisms. For example, TME actively recruits and activates platelets from the microcirculation to facilitate me…
View article: EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer
EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer Open
Endometrial cancer is the most frequent malignant tumor of the female reproductive tract but lacks effective therapy. EphA2, a receptor tyrosine kinase, is overexpressed by various cancers including endometrial cancer and is associated wit…
View article: High Prevalence of Fap+ Cancer-Associated Fibroblasts Predicts Poor Outcome in Patients with High-Grade Serous Ovarian Cancer with High Cd8 T-Cell Density
High Prevalence of Fap+ Cancer-Associated Fibroblasts Predicts Poor Outcome in Patients with High-Grade Serous Ovarian Cancer with High Cd8 T-Cell Density Open
View article: In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy
In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy Open
In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients with high-grade serous ovarian …
View article: Supplementary Table 1 from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Supplementary Table 1 from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer Open
Supplementary Table 1. Dataset for the reverse-phase protein array (RPPA) and processed data for Ingenuity Pathway Analysis.
View article: Data from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Data from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer Open
Abnormal activity of human prolactin (PRL) and its membrane-associated receptor (PRLR) contributes to the progression of uterine carcinoma. However, the underlying mechanisms are not well understood, and current means of targeting the PRL/…
View article: Supplementary Table 1 from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Supplementary Table 1 from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer Open
Supplementary Table 1. Dataset for the reverse-phase protein array (RPPA) and processed data for Ingenuity Pathway Analysis.
View article: Supplementary Table 1-3 and Figures 1-7. from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Supplementary Table 1-3 and Figures 1-7. from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer Open
Supplementary Materials and Methods, Supplementary Table S1. List of 9 PRLR gene isoforms in the UCSC Genome Browser based on RNASeqV2 data. Supplementary Table S2. Protein expression profile by RPPA analysis in Ishikawa tumors treated wit…
View article: Supplementary Data from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Supplementary Data from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer Open
Full report from Ingenuity Pathway Analysis of the RPPA results.
View article: Supplementary Data from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Supplementary Data from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer Open
Full report from Ingenuity Pathway Analysis of the RPPA results.
View article: Data from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Data from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer Open
Abnormal activity of human prolactin (PRL) and its membrane-associated receptor (PRLR) contributes to the progression of uterine carcinoma. However, the underlying mechanisms are not well understood, and current means of targeting the PRL/…
View article: Supplementary Table 1-3 and Figures 1-7. from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer
Supplementary Table 1-3 and Figures 1-7. from Blockade of the Short Form of Prolactin Receptor Induces FOXO3a/EIF-4EBP1–Mediated Cell Death in Uterine Cancer Open
Supplementary Materials and Methods, Supplementary Table S1. List of 9 PRLR gene isoforms in the UCSC Genome Browser based on RNASeqV2 data. Supplementary Table S2. Protein expression profile by RPPA analysis in Ishikawa tumors treated wit…
View article: Endothelial p130cas confers resistance to anti-angiogenesis therapy
Endothelial p130cas confers resistance to anti-angiogenesis therapy Open
(Cell Reports 38, 110301, January 25, 2022) We were made aware of readers’ concerns about potential image duplication in some of the figures from this article, which was originally published with the January 25, 2022 issue. For example, Fi…
View article: 2022-RA-1007-ESGO High expression of FAP+ cancer-associated fibroblasts predict poor outcome in patients with high-grade serous ovarian cancer with high CD8-postive T-cell infiltration
2022-RA-1007-ESGO High expression of FAP+ cancer-associated fibroblasts predict poor outcome in patients with high-grade serous ovarian cancer with high CD8-postive T-cell infiltration Open
View article: Molecular Analysis of Short- versus Long-Term Survivors of High-Grade Serous Ovarian Carcinoma
Molecular Analysis of Short- versus Long-Term Survivors of High-Grade Serous Ovarian Carcinoma Open
Despite having similar histologic features, patients with high-grade serous ovarian carcinoma (HGSC) often experience highly variable outcomes. The underlying determinants for long-term survival (LTS, ≥10 years) versus short-term survival …
View article: Molecular Profiles of Serum-Derived Extracellular Vesicles in High-Grade Serous Ovarian Cancer
Molecular Profiles of Serum-Derived Extracellular Vesicles in High-Grade Serous Ovarian Cancer Open
Patients with high-grade serous ovarian cancer (HGSC) who have no visible residual disease (R0) after primary surgery have the best clinical outcomes, followed by patients who undergo neoadjuvant chemotherapy (NACT) and have a response ena…
View article: Endothelial p130cas confers resistance to anti-angiogenesis therapy
Endothelial p130cas confers resistance to anti-angiogenesis therapy Open
(Cell Reports 38, 110301; January 25, 2022) In the original version of the article that was published with the January 25, 2022 issue, there were inadvertent errors introduced during figure assembly in Figures 2, 4, and 5. The original Fig…
View article: Leveraging mid-infrared spectroscopic imaging and deep learning for tissue subtype classification in ovarian cancer
Leveraging mid-infrared spectroscopic imaging and deep learning for tissue subtype classification in ovarian cancer Open
Mid-infrared spectroscopic imaging (MIRSI) is an emerging class of label-free techniques being leveraged for digital histopathology. Modern histopathologic identification of ovarian cancer involves tissue staining followed by morphological…
View article: Novel Markers for Liquid Biopsies in Cancer Management: Circulating Platelets and Extracellular Vesicles
Novel Markers for Liquid Biopsies in Cancer Management: Circulating Platelets and Extracellular Vesicles Open
Although radiologic imaging and histologic assessment of tumor tissues are classic approaches for diagnosis and monitoring of treatment response, they have many limitations. These include challenges in distinguishing benign from malignant …
View article: Spatially resolved transcriptomics of high-grade serous ovarian carcinoma
Spatially resolved transcriptomics of high-grade serous ovarian carcinoma Open
View article: Targeting CCR2+ macrophages with BET inhibitor overcomes adaptive resistance to anti-VEGF therapy in ovarian cancer
Targeting CCR2+ macrophages with BET inhibitor overcomes adaptive resistance to anti-VEGF therapy in ovarian cancer Open
Purpose Tumor-associated macrophages (TAMs) are known to contribute to adaptive resistance to anti-vascular endothelial growth factor (VEGF) antibody (AVA) therapy in ovarian cancer. BET (bromodomain and extra-terminal domain) inhibitors (…
View article: Endothelial p130cas confers resistance to anti-angiogenesis therapy
Endothelial p130cas confers resistance to anti-angiogenesis therapy Open
Anti-angiogenic therapies, such as anti-VEGF antibodies (AVAs), have shown promise in clinical settings. However, adaptive resistance to such therapies occurs frequently. We use orthotopic ovarian cancer models with AVA-adaptive resistance…
View article: Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status
Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status Open