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View article: <b>Dickkopf-3 (DKK3) </b><b>and the progression of diabetic kidney disease</b><b>in primary health care</b>
<b>Dickkopf-3 (DKK3) </b><b>and the progression of diabetic kidney disease</b><b>in primary health care</b> Open
Accurate prediction of diabetic kidney disease progression is challenging, but mandatory. Urinary Dickkopf-3 (uDKK3), a tubular epithelia-derived glycoprotein and marker of tubular injury, is a promising biomarker for kidney function decli…
View article: <b>Dickkopf-3 (DKK3) </b><b>and the progression of diabetic kidney disease</b><b>in primary health care</b>
<b>Dickkopf-3 (DKK3) </b><b>and the progression of diabetic kidney disease</b><b>in primary health care</b> Open
Accurate prediction of diabetic kidney disease progression is challenging, but mandatory. Urinary Dickkopf-3 (uDKK3), a tubular epithelia-derived glycoprotein and marker of tubular injury, is a promising biomarker for kidney function decli…
View article: Dickkopf-3 (DKK3) and the Progression of Diabetic Kidney Disease in Primary Health Care
Dickkopf-3 (DKK3) and the Progression of Diabetic Kidney Disease in Primary Health Care Open
Accurate prediction of diabetic kidney disease progression is challenging, but mandatory. Urinary Dickkopf-3 (uDKK3), a tubular, epithelial-derived glycoprotein and marker of tubular injury, is a promising biomarker for kidney function dec…
View article: Extrarenal “crescent” in multisystem granulomatosis with polyangiitis
Extrarenal “crescent” in multisystem granulomatosis with polyangiitis Open
View article: Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease
Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease Open
Introduction: Diabetic kidney disease (DKD) is a common cause of chronic kidney disease with around 25–40% of patients with diabetes being affected. The course of DKD is variable, and estimated glomerular filtration rate (eGFR) and albumin…
View article: Tissue Iron Distribution in Anemic Patients with End-Stage Kidney Disease: Results of a Pilot Study
Tissue Iron Distribution in Anemic Patients with End-Stage Kidney Disease: Results of a Pilot Study Open
Background/Objectives: Anemia is a frequent multifactorial co-morbidity in end-stage kidney disease (ESKD) associated with morbidity and poor QoL. Apart from insufficient erythropoietin formation, iron deficiency (ID) contributes to anemia…
View article: Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus
Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus Open
View article: Randomized Trial of SGLT2 Inhibitor Identifies Target Proteins in Diabetic Kidney Disease
Randomized Trial of SGLT2 Inhibitor Identifies Target Proteins in Diabetic Kidney Disease Open
The current study discovers the urinary proteome impacted by the SGLT2i, thereby providing new potential target sites and pathways, especially relating to wound healing and inflammation.
View article: Exercise-Induced Fluid Retention, Cardiac Volume Overload, and Peripheral Edema in Ultra-Distance Cyclists
Exercise-Induced Fluid Retention, Cardiac Volume Overload, and Peripheral Edema in Ultra-Distance Cyclists Open
View article: #4951 NON-ADHERENCE TO CARDIOMETABOLIC DRUGS AS ASSESSED BY LS-MS/MS IN URINE AND ITS ASSOCIATION WITH RENAL AND CARDIOVASCULAR OUTCOMES IN T2DM
#4951 NON-ADHERENCE TO CARDIOMETABOLIC DRUGS AS ASSESSED BY LS-MS/MS IN URINE AND ITS ASSOCIATION WITH RENAL AND CARDIOVASCULAR OUTCOMES IN T2DM Open
Background and Aims Cardiovascular and renal complications have a detrimental impact on the prognosis and quality of life of patients with type 2 diabetes mellitus (T2DM). Guidelines recommend combination drug therapy to prevent or delay t…
View article: Präzision der Prognose von Nierenerkrankungen bei Diabetes mellitus Typ 2
Präzision der Prognose von Nierenerkrankungen bei Diabetes mellitus Typ 2 Open
Zusammenfassung Bis zu 40 % der Patient:innen mit Diabetes mellitus Typ 2 entwickeln eine chronische Nierenerkrankung, aber nur ein relativ kleinen Teil eine terminale Niereninsuffizienz. Eine Einschätzung der individuellen renalen Prognos…
View article: International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe
International Variability of Renal and Cardiovascular Outcomes and Mortality in Patients with Type 2 Diabetes Mellitus in Europe Open
Introduction: Type 2 diabetes and its complications represent a huge burden to public health. With this prospective, observational cohort study, we aimed to estimate and to compare the incidence rate (IR) of renal and cardiov…
View article: Supplementary Material for: International variability of renal and cardiovascular outcomes and mortality in patients with type 2 diabetes mellitus in Europe
Supplementary Material for: International variability of renal and cardiovascular outcomes and mortality in patients with type 2 diabetes mellitus in Europe Open
Introduction Type 2 diabetes and its complications represent a huge burden to public health. With this prospective, observational cohort study, we aimed to estimate and to compare the incidence rate (IR) of renal and cardiovascular outcome…
View article: Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis
Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis Open
Fibrinogen-like 2 (FGL2) was recently found to be associated with fibrosis in a mouse model of kidney damage and was proposed as a potential therapeutic target in chronic kidney disease (CKD). We assessed the association of renal FGL2 mRNA…
View article: Biological variation and reference change value of the estimated glomerular filtration rate in humans: A systematic review and meta-analysis
Biological variation and reference change value of the estimated glomerular filtration rate in humans: A systematic review and meta-analysis Open
Background Knowledge of the biological variation of serum or plasma creatinine (Cr) and the estimated glomerular filtration rate (eGFR) is important for understanding disease dynamics in Chronic Kidney Disease (CKD). The aim of our study w…
View article: Sarcoid-like lesions obfuscating the diagnosis of disseminated Mycobacterium genavense infection in a patient with IL-12Rβ1-associated immunodeficiency
Sarcoid-like lesions obfuscating the diagnosis of disseminated Mycobacterium genavense infection in a patient with IL-12Rβ1-associated immunodeficiency Open
Background Sarcoidosis is a systemic inflammatory disease that is characterized by non-caseating epithelioid-cell granulomas upon histology. However, similar histological findings may also be seen with certain infections. Thus, differentia…
View article: Response
Response Open
As the authors of the letter mention, it is a major challenge to interpret variants when investigating clonal hematopoiesis of indeterminate potential (CHIP). Undoubtedly, there are possibilities to identify passenger variants, benign vari…
View article: Clonal Hematopoiesis of Indeterminate Potential and Diabetic Kidney Disease: A Nested Case-Control Study
Clonal Hematopoiesis of Indeterminate Potential and Diabetic Kidney Disease: A Nested Case-Control Study Open
View article: In silico deconjugation of glucuronide conjugates enhances tandem mass spectra library annotation of human samples
In silico deconjugation of glucuronide conjugates enhances tandem mass spectra library annotation of human samples Open
View article: Non-adherence to antidiabetic and cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes: A narrative review
Non-adherence to antidiabetic and cardiovascular drugs in type 2 diabetes mellitus and its association with renal and cardiovascular outcomes: A narrative review Open
Cardiovascular and renal complications are a major burden for individuals with type 2 diabetes mellitus (T2DM). Besides lifestyle interventions, current guidelines recommend combination drug therapy to prevent or delay the incidence and pr…
View article: Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of <i>in vitro</i>, <i>in vivo</i>, and clinical trials
Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of <i>in vitro</i>, <i>in vivo</i>, and clinical trials Open
Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic ag…
View article: Intra-individual variability of eGFR trajectories in early diabetic kidney disease and lack of performance of prognostic biomarkers
Intra-individual variability of eGFR trajectories in early diabetic kidney disease and lack of performance of prognostic biomarkers Open
View article: Immunopathogenesis of ANCA-Associated Vasculitis
Immunopathogenesis of ANCA-Associated Vasculitis Open
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder which affects small- and, to a lesser degree, medium-sized vessels. ANCA-associated vasculitis encompasses three disease phenotypes: granulomatosis…
View article: Is There Decreasing Public Interest in Renal Transplantation? A Google TrendsTM Analysis
Is There Decreasing Public Interest in Renal Transplantation? A Google TrendsTM Analysis Open
Background and objectives: Renal transplantation is the preferred form of renal replacement therapy for the majority of patients with end stage renal disease (ESRD). The Internet is a key tool for people seeking healthcare-related informat…