Sara E. Hartmann
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View article: Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells
Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells Open
T-cell activation is a highly regulated process requiring both antigen recognition via the T-cell receptor (TCR) and co-stimulatory signaling, notably through the co-stimulatory receptor CD28. Here, we introduce an optogenetic platform for…
View article: Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules
Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules Open
This study aimed to quantify the effect of two consecutive prolonged, intermittent exposures to high and very high altitudes on oxygen saturation (SpO2) and acute mountain sickness (AMS). For this, healthy lowlanders (N = 21), aged 18-30 y…
View article: Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules
Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules Open
Objective To quantify the effect of two consecutive prolonged, intermittent exposures to high and very high altitudes on oxygen saturation (SpO 2 ) and acute mountain sickness (AMS). Methods Healthy lowlanders (N=21), aged 18-30y, underwen…
View article: Phospho-mimetic CD3ε variants prevent TCR and CAR signaling
Phospho-mimetic CD3ε variants prevent TCR and CAR signaling Open
Introduction Antigen binding to the T cell antigen receptor (TCR) leads to the phosphorylation of the immunoreceptor tyrosine-based activation motifs (ITAMs) of the CD3 complex, and thereby to T cell activation. The CD3ε subunit plays a un…
View article: Brevundimonas and Serratia as host systems for assessing associated environmental viromes and phage diversity by complementary approaches
Brevundimonas and Serratia as host systems for assessing associated environmental viromes and phage diversity by complementary approaches Open
Focusing on visible plaques for phage isolation leaves the question if we miss the diversity of non-plaque forming phages. We addressed this question through direct plaque-based isolation by employing the new hosts Brevundimonas pondensis …
View article: Acute high altitude exposure, acclimatization and re-exposure on nocturnal breathing
Acute high altitude exposure, acclimatization and re-exposure on nocturnal breathing Open
Background: Effects of prolonged and repeated high-altitude exposure on oxygenation and control of breathing remain uncertain. We hypothesized that prolonged and repeated high-altitude exposure will improve altitude-induced deoxygenation a…
View article: A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling Open
Alterations in both the expression and function of the non-receptor tyrosine kinase Zap70 are associated with numerous human diseases including immunodeficiency, autoimmunity, and leukemia. Zap70 propagates the TCR signal by phosphorylatin…
View article: Effect of Fast Ascent, Acclimatization and Re-Exposure To 5050 m On Cerebral Autoregulation in Unacclimatized Lowlanders. A Prospective Cohort Study.
Effect of Fast Ascent, Acclimatization and Re-Exposure To 5050 m On Cerebral Autoregulation in Unacclimatized Lowlanders. A Prospective Cohort Study. Open
ABSTRACT Cerebral autoregulation (CA) is impaired during acute high-altitude (HA) exposure and effects of acclimatization and re-exposure on CA are unknown. In 18 healthy lowlanders (11 women), we hypothesized that the cerebral autoregulat…
View article: Extravascular lung water and cardiac function assessed by echocardiography in healthy lowlanders during repeated very high-altitude exposure
Extravascular lung water and cardiac function assessed by echocardiography in healthy lowlanders during repeated very high-altitude exposure Open
Exposure to 5050 m induced a rapid increase in sPAP. B-lines rose during prolonged exposures to 5050 m, despite gradual decrease in sPAP, indicating excessive hydrostatic pressure might not be solely responsible for EVLW-development. Repea…
View article: Effects on Cognitive Functioning of Acute, Subacute and Repeated Exposures to High Altitude
Effects on Cognitive Functioning of Acute, Subacute and Repeated Exposures to High Altitude Open
Objective: Neurocognitive functions are affected by high altitude, however the altitude effects of acclimatization and repeated exposures are unclear. We investigated the effects of acute, subacute and repeated exposure to 5,050 m on cogni…
View article: Effect of Acute, Subacute, and Repeated Exposure to High Altitude (5050 m) on Psychomotor Vigilance
Effect of Acute, Subacute, and Repeated Exposure to High Altitude (5050 m) on Psychomotor Vigilance Open
Aim: High altitude (HA) hypoxia may affect cognitive performance and sleep quality. Further, vigilance is reduced following sleep deprivation. We investigated the effect on vigilance, actigraphic sleep indices, and their relationships with…
View article: Exercise Performance of Lowlanders with COPD at 2,590 m: Data from a Randomized Trial
Exercise Performance of Lowlanders with COPD at 2,590 m: Data from a Randomized Trial Open
Background: Effects of hypobaric hypoxia at altitude on exercise performance of lowlanders with chronic obstructive pulmonary disease (COPD) have not been studied in detail. Objectives: To quantify changes in exercise performance and assoc…
View article: Human cerebral blood flow control during hypoxia: focus on chronic pulmonary obstructive disease and obstructive sleep apnea
Human cerebral blood flow control during hypoxia: focus on chronic pulmonary obstructive disease and obstructive sleep apnea Open
The brain is a vital organ that relies on a constant and adequate blood flow to match oxygen and glucose delivery with the local metabolic demands of active neurons. Thus exquisite regulation of cerebral blood flow (CBF) is particularly im…
View article: Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration
Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration Open
Patients with chronic obstructive pulmonary disease (COPD) have decreased ventilatory and cerebrovascular responses to hypercapnia. Antioxidants increase the ventilatory response to hypercapnia in healthy humans. Cerebral blood flow is an …
View article: Cerebrovascular and Ventilatory Function in Chronic Obstructive Pulmonary Disease
Cerebrovascular and Ventilatory Function in Chronic Obstructive Pulmonary Disease Open
Chronic Obstructive Pulmonary Disease (COPD) is a disease primarily affecting the pulmonary system, most commonly resulting from prolonged exposure to cigarette smoke. While systemic respiratory disturbances in COPD are apparent, the chemi…