Sara E. Maloney
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View article: Aerosol particle design to promote targeting in the respiratory tract
Aerosol particle design to promote targeting in the respiratory tract Open
View article: Characterization of new mouse models of acute and chronic <i>Mycobacterium abscessus</i> infection for antimicrobial drug screening
Characterization of new mouse models of acute and chronic <i>Mycobacterium abscessus</i> infection for antimicrobial drug screening Open
Mycobacterium abscessus (MAB), a rapidly growing non-tuberculous mycobacterium, is becoming increasingly recognized as a significant pathogen affecting humans. These bacteria particularly impact individuals with cystic fibrosis (CF), non-C…
View article: Injectable Polysaccharide Hydrogels as Localized Nitric Oxide Delivery Formulations
Injectable Polysaccharide Hydrogels as Localized Nitric Oxide Delivery Formulations Open
A series of injectable polysaccharide hydrogels are prepared with oxidized dextran and diethylenetriamine‐modified carboxymethylcellulose (CMC) or hyaluronic acid (HA). Rheological evaluation reveals that CMC‐based hydrogels achieve storag…
View article: Outstanding Contributions to Aerosol Pulmonary Drug Delivery
Outstanding Contributions to Aerosol Pulmonary Drug Delivery Open
View article: Biopolymeric Inhalable Dry Powders for Pulmonary Drug Delivery
Biopolymeric Inhalable Dry Powders for Pulmonary Drug Delivery Open
Natural and synthetic biopolymers are gaining popularity in the development of inhaled drug formulations. Their highly tunable properties and ability to sustain drug release allow for the incorporation of attributes not achieved in dry pow…
View article: Assessment of tuberculosis drug efficacy using preclinical animal models and in vitro predictive techniques
Assessment of tuberculosis drug efficacy using preclinical animal models and in vitro predictive techniques Open
Tuberculosis (TB) killed approximately 1.3 million people in 2022 and remains a leading cause of death from the bacteria Mycobacterium tuberculosis (M.tb); this number of deaths was surpassed only by COVID-19, caused by the SARS-CoV-2 viru…
View article: Biopolymeric Inhalable Dry Powders for Pulmonary Drug Delivery
Biopolymeric Inhalable Dry Powders for Pulmonary Drug Delivery Open
Natural and synthetic biopolymers are gaining popularity in the development of inhaled drug formulations. Their highly tunable properties and ability to sustain drug release allow for the incorporation of attributes not achieved in dry pow…
View article: Practical Considerations in Dose Extrapolation from Animals to Humans
Practical Considerations in Dose Extrapolation from Animals to Humans Open
Animal studies are an important component of drug product development and the regulatory review process since modern practices have been in place, for almost a century. A variety of experimental systems are available to generate aerosols f…
View article: Disposable Dosators Intended for Dry Powder Delivery to Mice
Disposable Dosators Intended for Dry Powder Delivery to Mice Open
Dry powder inhalers offer numerous advantages for delivering drugs to the lungs, including stable solid-state drug formulations, device portability, bolus metering and dosing, and a propellant-free dispersal mechanism. To develop pharmaceu…
View article: Preparation Strategies of the Anti-Mycobacterial Drug Bedaquiline for Intrapulmonary Routes of Administration
Preparation Strategies of the Anti-Mycobacterial Drug Bedaquiline for Intrapulmonary Routes of Administration Open
Mycobacterium tuberculosis (M.tb) has infected one-quarter of the world’s population and led to the deaths of 1.6 million individuals in 2021 according to estimates from the World Health Organization. The rise in prevalence of multidrug-re…
View article: Injectable Polysaccharide Hydrogels as Localized Nitric Oxide Delivery Formulations
Injectable Polysaccharide Hydrogels as Localized Nitric Oxide Delivery Formulations Open
A series of injectable polysaccharide hydrogels are prepared with oxidized dextran and diethylenetriamine‐modified carboxymethylcellulose (CMC) or hyaluronic acid (HA). Rheological evaluation reveals that CMC‐based hydrogels achieve storag…
View article: Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections
Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections Open
View article: Optimization and Scale Up of Spray Dried CPZEN-45 Aerosol Powders for Inhaled Tuberculosis Treatment
Optimization and Scale Up of Spray Dried CPZEN-45 Aerosol Powders for Inhaled Tuberculosis Treatment Open
View article: Performance Testing for Dry Powder Inhaler Products: Towards Clinical Relevance
Performance Testing for Dry Powder Inhaler Products: Towards Clinical Relevance Open
It is well established that the critical performance metrics for aerosol products are aerodynamic particle size distribution (APSD) and delivered dose uniformity (DDU). In broad terms, these performance characteristics dictate the efficien…
View article: Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing
Role of Nitric Oxide-Releasing Glycosaminoglycans in Wound Healing Open
Two glycosaminoglycan (GAG) biopolymers, hyaluronic acid (HA) and chondroitin sulfate (CS), were chemically modified via carbodiimide chemistry to facilitate the loading and release of nitric oxide (NO) to develop a multi-action wound heal…
View article: 506: Effects of mucin and DNA concentrations in mucus on Pseudomonas aeruginosa biofilm recalcitrance
506: Effects of mucin and DNA concentrations in mucus on Pseudomonas aeruginosa biofilm recalcitrance Open
View article: Nitric Oxide Therapy for Diabetic Wound Healing
Nitric Oxide Therapy for Diabetic Wound Healing Open
Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for wound healing; liberating NO from endogenous rese…
View article: Nitric oxide diffusion through cystic fibrosis-relevant media and lung tissue
Nitric oxide diffusion through cystic fibrosis-relevant media and lung tissue Open
Nitric oxide diffusion monitored through artificial sputum medium using an adaptable diffusion cell and released from donor through human lung tissue.