Sara Fidalgo
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View article: Decreases in mucosally‐evoked tachykinin signaling pathways can explain age‐related reductions in murine colonic motility patterns
Decreases in mucosally‐evoked tachykinin signaling pathways can explain age‐related reductions in murine colonic motility patterns Open
Background Increasing age increases the incidence of chronic constipation and fecal impaction. The contribution of the natural aging process to this phenotype is unclear. This study explored the effects of age on key motility patterns in t…
View article: Amperometry approach curve profiling to understand the regulatory mechanisms governing the concentration of intestinal extracellular serotonin
Amperometry approach curve profiling to understand the regulatory mechanisms governing the concentration of intestinal extracellular serotonin Open
Enterochromaffin (EC) cells located within the intestinal mucosal epithelium release serotonin (5-HT) to regulate motility tones, barrier function and the immune system. Electroanalytical methodologies have been able to monitor steady stat…
View article: Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan
Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation of Lifespan Open
View article: Changes in murine anorectum signaling across the life course
Changes in murine anorectum signaling across the life course Open
Background Increasing age is associated with an increase in the incidence of chronic constipation and fecal impaction. The contribution of the natural aging process to these conditions is not fully understood. This study examined the effec…
View article: Prenatal alcohol exposure reduces 5-HT concentration in mouse intestinal muscle and mucosa
Prenatal alcohol exposure reduces 5-HT concentration in mouse intestinal muscle and mucosa Open
View article: The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice
The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice Open
Treatment for chronic constipation in older people is challenging and the condition has a major impact on quality of life. A lack of understanding about the causes of this condition has hampered the development of effective treatments. 5-H…
View article: Guiding Intervention- Identifying parental psychological risk factors which contribute towards children pre-operative anxiety
Guiding Intervention- Identifying parental psychological risk factors which contribute towards children pre-operative anxiety Open