Sara Franceschelli
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View article: Biological Modulation of Autophagy by Nanoplastics: A Current Overview
Biological Modulation of Autophagy by Nanoplastics: A Current Overview Open
Nanoplastics (NPs), an emerging class of environmental pollutants, are increasingly recognized for their potential to interfere with critical cellular processes. Autophagy, a conserved degradative pathway essential for maintaining cellular…
View article: The Influence of Different Preservation Protocols on the Teeth’s Osteoinductive Characteristics: An In Vitro Study
The Influence of Different Preservation Protocols on the Teeth’s Osteoinductive Characteristics: An In Vitro Study Open
The purpose of this study was to evaluate in vitro whether the type of tooth preservation before treatment with the Tooth Transformer® (TT) device affects the osteoinductive characteristics of the extracted tooth. Forty extracted teeth fro…
View article: Anti-inflammatory activity of magnetic fields emitted by graphene devices on cultured human cells
Anti-inflammatory activity of magnetic fields emitted by graphene devices on cultured human cells Open
View article: Biological Response of Treatment with Saffron Petal Extract on Cytokine-Induced Oxidative Stress and Inflammation in the Caco-2/Human Leukemia Monocytic Co-Culture Model
Biological Response of Treatment with Saffron Petal Extract on Cytokine-Induced Oxidative Stress and Inflammation in the Caco-2/Human Leukemia Monocytic Co-Culture Model Open
The pathogenesis of Inflammatory Bowel Disease (IBD) involves complex mechanisms, including immune dysregulation, gut microbiota imbalances, oxidative stress, and defects in the gastrointestinal mucosal barrier. Current treatments for IBD …
View article: Biological effects of magnetic fields emitted by graphene devices, on induced oxidative stress in human cultured cells
Biological effects of magnetic fields emitted by graphene devices, on induced oxidative stress in human cultured cells Open
Many recent studies have explored the healing properties of the extremely low-frequency electromagnetic field (ELF-EMF) to utilize electromagnetism for medical purposes. The non-invasiveness of electromagnetic induction makes it valuable f…
View article: Anti-Inflammatory effect of the Saffron Stigma and Saffron Petal Extract on LPS stimulated human Caco-2 cell by transductional signal modulation of FBW7/IKBα
Anti-Inflammatory effect of the Saffron Stigma and Saffron Petal Extract on LPS stimulated human Caco-2 cell by transductional signal modulation of FBW7/IKBα Open
Although the progression of IBD therapy is controlled with chemical drugs and biological therapies, healing results cannot yet be achieved, along with the inevitable side effects. As a result, a variety of research have focused on explorin…
View article: Biological Evaluation of the Osteoinductive Potential of Dry Teeth after Chemical Demineralization Treatment Using the Tooth Transformer Device
Biological Evaluation of the Osteoinductive Potential of Dry Teeth after Chemical Demineralization Treatment Using the Tooth Transformer Device Open
Several studies have already demonstrated the biocompatibility of a tooth as a grafting material in the regeneration of bone tissue, showing its osteoconductive potential, while no studies have verified whether the osteoinductive potential…
View article: Combined Rehabilitation Protocol in the Treatment of Osteoarthritis of the Knee: Comparative Study of Extremely Low-Frequency Magnetic Fields and Soft Elastic Knee Brace Effect
Combined Rehabilitation Protocol in the Treatment of Osteoarthritis of the Knee: Comparative Study of Extremely Low-Frequency Magnetic Fields and Soft Elastic Knee Brace Effect Open
The investigation of this observational case–control study aimed at determining the effectiveness of a combined treatment of extremely low-frequency electromagnetic fields (ELF) with a soft elastic knee brace versus ELF alone in knee osteo…
View article: Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway
Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway Open
Cholesterol accumulation in macrophages leads to the formation of foam cells and increases the risk of developing atherosclerosis. We have verified whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory and antioxidant pro…
View article: Inflammatory Bowel Disease (IBD): a novel biological role of saffron petal extracts as a modulator of phlogistic pathway via FBW7/NF-kB in Caco-2 cell line LPS-stimulated
Inflammatory Bowel Disease (IBD): a novel biological role of saffron petal extracts as a modulator of phlogistic pathway via FBW7/NF-kB in Caco-2 cell line LPS-stimulated Open
Inflammatory bowel disease (IBD) is a chronic pathology characterized by extensive inflammation, which causes a functional alteration of the intestinal barrier. Today most of the drugs applied for IBD have adverse consequences. In this sce…
View article: Mitochondrial Aging and Senolytic Natural Products with Protective Potential
Mitochondrial Aging and Senolytic Natural Products with Protective Potential Open
Living organisms do not disregard the laws of thermodynamics and must therefore consume energy for their survival. In this way, cellular energy exchanges, which aim above all at the production of ATP, a fundamental molecule used by the cel…
View article: Salivary oxytocin, cognitive anxiety and self-confidence in pre-competition athletes
Salivary oxytocin, cognitive anxiety and self-confidence in pre-competition athletes Open
View article: Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases
Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases Open
The growing incidence of cardiovascular disease (CVD) has promoted investigations of natural molecules that could prevent and treat CVD. Among these, hydroxytyrosol, a polyphenolic compound of olive oil, is well known for its antioxidant, …
View article: Anti-Migratory Effects of 4′-Geranyloxyferulic Acid on LPS-Stimulated U937 and HCT116 Cells via MMP-9 Down-Regulation: Involvement of ROS/ERK Signaling Pathway
Anti-Migratory Effects of 4′-Geranyloxyferulic Acid on LPS-Stimulated U937 and HCT116 Cells via MMP-9 Down-Regulation: Involvement of ROS/ERK Signaling Pathway Open
Matrix metalloproteinases (MMPs) play a crucial role in tumor angiogenesis, and metastasis. 4′-geranyloxyferulic acid (GOFA) has anti-tumor and anti-inflammatory proprieties. Herein, we aimed to determine whether this compound affects cell…
View article: Erythropoietin induces miRNA‐210 by JAK2/STAT5 signaling in PBMCs of End‐stage Renal Disease patients
Erythropoietin induces miRNA‐210 by JAK2/STAT5 signaling in PBMCs of End‐stage Renal Disease patients Open
Anemia of chronic kidney disease is associated with blunted response/resistance to erythropoietin‐stimulating agents (ESAs) in hemodialysis (HD) patients. Several molecules have been successfully associated with ESA responsiveness; however…
View article: Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H2O2-Induced Cellular Toxicity
Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H2O2-Induced Cellular Toxicity Open
The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage Parkinson’s disease (PD) and to control its symptoms. However, LD could cause disease neurotoxicity due to the generation of pro-oxidant intermediates…
View article: Modulation of CAT-2B-Mediated l-Arginine Uptake and Nitric Oxide Biosynthesis in HCT116 Cell Line Through Biological Activity of 4′-Geranyloxyferulic Acid Extract from Quinoa Seeds
Modulation of CAT-2B-Mediated l-Arginine Uptake and Nitric Oxide Biosynthesis in HCT116 Cell Line Through Biological Activity of 4′-Geranyloxyferulic Acid Extract from Quinoa Seeds Open
Chenopodium quinoa Wild is a “pseudocereal” grain which attracts a lot of attention in the scientific community as it has a positive effect on health. Here, we investigate the presence of biologically active O-prenylated phenylpropanoids i…
View article: Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision
Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision Open
Gastroesophageal reflux disease ( GERD ), a clinical condition characterized by reflux of gastroduodenal contents in the oesophagus, has proved to demonstrate a strong link between oxidative stress and the development of GERD . Proton pump…
View article: The plasmatic and salivary levels of IL-1β, IL-18 and IL-6 are associated to emotional difference during stress in young male
The plasmatic and salivary levels of IL-1β, IL-18 and IL-6 are associated to emotional difference during stress in young male Open
View article: Extremely low‐frequency electromagnetic fields accelerates wound healing modulating <scp>MMP</scp>‐9 and inflammatory cytokines
Extremely low‐frequency electromagnetic fields accelerates wound healing modulating <span>MMP</span>‐9 and inflammatory cytokines Open
Objectives In our previous reports, we have demonstrated that extremely low‐frequency electromagnetic fields ( ELF ‐ EMF ) exposure enhances the proliferation of keratinocyte. The present study aimed to clarify effects of ELF ‐ EMF on woun…
View article: Erythropoietin Induces miRNA210 by JAK2/STAT5 Signaling in PBMCs of End Stage Renal Disease Patients
Erythropoietin Induces miRNA210 by JAK2/STAT5 Signaling in PBMCs of End Stage Renal Disease Patients Open
View article: Aging-Related Oxidative Stress: Positive Effect of Memory Training
Aging-Related Oxidative Stress: Positive Effect of Memory Training Open
The cognitive impairment characterizing the phenotype of older adults has been related to the efficiency of the antioxidant system. This study aimed at investigating the effect of memory training (MT) on memory, global cognitive functionin…
View article: Memory Training Program Decreases the Circulating Level of Cortisol and Pro-inflammatory Cytokines in Healthy Older Adults
Memory Training Program Decreases the Circulating Level of Cortisol and Pro-inflammatory Cytokines in Healthy Older Adults Open
Aging cognitive decline has been associated to impairment of the Hypothalamus Pituitary Adrenals (HPA) axis activity and a higher level of the systemic inflammation. However, little is known about the molecules driving this process at peri…
View article: Biological Effect of Licochalcone C on the Regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO Signaling Pathways in H9c2 Cells in Response to LPS Stimulation
Biological Effect of Licochalcone C on the Regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO Signaling Pathways in H9c2 Cells in Response to LPS Stimulation Open
Polyphenols compounds are a group molecules present in many plants. They have antioxidant properties and can also be helpful in the management of sepsis. Licochalcone C (LicoC), a constituent of Glycyrrhiza glabra, has various biological a…
View article: Argumentos de estabilidad en el studio de la morfogénesis
Argumentos de estabilidad en el studio de la morfogénesis Open
International audience
View article: Arguments of stability in the study of morphogenesis
Arguments of stability in the study of morphogenesis Open
Arguments of stability, intended in a wide sense, including the discussion of the conditions of the onset of instability and of stability changes, play a central role in the main theorizations of morphogenesis in 20th century theoretical b…
View article: New Approach in Translational Medicine: Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS Pathway in U937 Cell Line under Altered Redox State
New Approach in Translational Medicine: Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS Pathway in U937 Cell Line under Altered Redox State Open
It is known that increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) can exert harmful effects, altering the cellular redox state. Electrolyzed Reduced Water (ERW) produced near the cathode during water el…
View article: mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes
mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes Open
Several reports suggest that ELF-EMF exposures interact with biological processes including promotion of cell proliferation. However, the molecular mechanisms by which ELF-EMF controls cell growth are not completely understood. The present…
View article: Verbascoside down‐regulates some pro‐inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase <scp>SHP</scp>‐1 in the U937 cell line
Verbascoside down‐regulates some pro‐inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase <span>SHP</span>‐1 in the U937 cell line Open
Polyphenols are the major components of many traditional herbal remedies, which exhibit several beneficial effects including anti‐inflammation and antioxidant properties. Src homology region 2 domain‐containing phosphatase‐1 ( SHP ‐1) is a…