Sara Galozzi
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View article: Protein variability in cerebrospinal fluid and its possible implications for neurological protein biomarker research
Protein variability in cerebrospinal fluid and its possible implications for neurological protein biomarker research Open
Cerebrospinal fluid is investigated in biomarker studies for various neurological disorders of the central nervous system due to its proximity to the brain. Currently, only a limited number of biomarkers have been validated in independent …
View article: Characterization of Cerebrospinal Fluid via Data-Independent Acquisition Mass Spectrometry
Characterization of Cerebrospinal Fluid via Data-Independent Acquisition Mass Spectrometry Open
Cerebrospinal fluid (CSF) is in direct contact with the brain and serves as a valuable specimen to examine diseases of the central nervous system through analyzing its components. These include the analysis of metabolites, cells as well as…
View article: Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease
Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease Open
Objective: The purpose of this study was to profile cerebrospinal fluid (CSF) from early‐stage PD patients for disease‐related metabolic changes and to determine a robust biomarker signature for early‐stage PD diagnosis. Methods: By applyi…
View article: Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis
Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis Open
Objective Sporadic inclusion body myositis (sIBM) pathogenesis is unknown; however, rimmed vacuoles (RVs) are a constant feature. We propose to identify proteins that accumulate within RVs. Methods RVs and intact myofibers were laser micro…
View article: Development of mass spectrometry-based identification and quantification methods for protein biomarkers in Alzheimer’s and Parkinson’s diseases
Development of mass spectrometry-based identification and quantification methods for protein biomarkers in Alzheimer’s and Parkinson’s diseases Open
Ziel der Arbeit war es, Massenspektrometrie(MS)-basierte Methoden für die Quantifizierung der beiden für Morbus Alzheimer (AD) etablierten Biomarker (A\(\beta\)-Peptid und Tau-Protein) zu entwickeln und potentielle Biomarker für Morbus Par…