Elizabeth Gordón
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View article: Oral Blarcamesine Phase IIb/III Trial Confirms Identified Precision Medicine Patient Population – Significant Broad Clinical and Quality of Life Improvements for Early Alzheimer’s Disease Patients
Oral Blarcamesine Phase IIb/III Trial Confirms Identified Precision Medicine Patient Population – Significant Broad Clinical and Quality of Life Improvements for Early Alzheimer’s Disease Patients Open
IMPORTANCE There are no approved oral disease-modifying treatments for Alzheimer’s disease (AD) with the ability to prolong time in a stable disease state and with clinically meaningful outcomes clear to patients and caregivers. DESIGN The…
Clinical Phenotypes of Alzheimer’s Disease: Atrophy Patterns and their Pathological Correlates Open
Background Recent studies highlight distinct patterns of cortical atrophy between amnestic (typical) and non‐amnestic (atypical, with subtypes: behavioural, dysexecutive, logopenic and visuospatial) clinical phenotypes of Alzheimer’s disea…
Clinical Phenotypes of Alzheimer's Disease: Atrophy Patterns and their Pathological Correlates Open
Background Recent studies highlight distinct patterns of cortical atrophy between amnestic (typical) and non‐amnestic (atypical, with subtypes: behavioural, dysexecutive, logopenic and visuospatial) clinical phenotypes of Alzheimer’s disea…
Validation of QyScore® White Matter Hyperintensity (WMH) U‐Net segmentation algorithm against expert manual consensus and comparison with currently available state‐of‐the‐art methods Open
Background Detection and quantification of White Matter Hyperintensities (WMH) are clinically important across multiple CNS disorders and neurodegenerative dementias. However, the prohibitively labor‐intensive nature of manual segmentation…
Qypredict®: A promising prognostic tool for anti‐amyloid therapy patient prioritization Open
Background The approval of anti‐amyloid therapies has led to a breakthrough in the treatment of Alzheimer’s disease. However, given these treatments remain expensive and are associated with significant side effects, identifying patients th…
View article: Long-term effects of SARS-CoV-2 infection in patients with and without chemosensory disorders at disease onset: a psychophysical and magnetic resonance imaging exploratory study
Long-term effects of SARS-CoV-2 infection in patients with and without chemosensory disorders at disease onset: a psychophysical and magnetic resonance imaging exploratory study Open
A preserved sense of smell and taste allows us to understand many environmental “messages” and results in meaningfully improvements to quality of life. With the COVID-19 pandemic, it became clear how important these senses are for social a…
An automated pipeline for Centiloid quantification of amyloid‐β using multiple <sup>11</sup>C‐PiB‐PET and <sup>18</sup>F‐PET tracers Open
Background Quantitative measures of amyloid‐β (Aβ) pathology using positron emission tomography (PET) imaging are sensitive to identify pathological changes early in Alzheimer’s disease (AD). The Centiloid scale aims to standardize these i…
Clinical Phenotypes of Alzheimer’s Disease: Pathological Correlates of Regional Cortical Volume Open
Background Recent studies highlight distinct patterns of cortical atrophy in amnestic (typical) and non‐amnestic (atypical – behavioural, dysexecutive and visuospatial) clinical phenotypes of Alzheimer’s disease (AD). The current study aim…
QyPredict prognostic model enriches selection for faster decliners in mild cognitive impairment Open
Background The suboptimal selection of patients is a key challenge for disease‐modifying trials in mild cognitive impairment (MCI) and Alzheimer’s disease. Improved selection strategies are urgently needed to better power trials. Recent ad…
Validation of QyScore’s® fully automated quantitative image segmentation tools against expert manual gold‐standards Open
Background Quantitative imaging provides valuable information for early detection, disease progression and treatment response monitoring. Manual segmentation is the current gold‐standard, but is prohibitively labour‐intensive for large sca…
Validation of QyScore’s® fully automated quantitative image segmentation tools against expert manual gold‐standards Open
Background Quantitative imaging provides valuable information for early detection, disease progression and treatment response monitoring. Manual segmentation is the current gold‐standard, but is prohibitively labour‐intensive for large sca…
An automated pipeline for Centiloid quantification of amyloid‐β using multiple 11C‐PiB‐PET and 18F‐PET tracers Open
Background Quantitative measures of amyloid‐ß (Aß) pathology using positron emission tomography (PET) imaging are sensitive to identify pathological changes early in Alzheimer’s disease (AD). The Centiloid scale aims to standardize these i…
QyPredict prognostic model enriches selection for faster decliners in mild cognitive impairment Open
Background The suboptimal selection of patients is a key challenge for disease‐modifying trials in mild cognitive impairment (MCI) and Alzheimer’s disease. Improved selection strategies are urgently needed to better power trials. Recent ad…
Subcortical atrophy imaging biomarker performance across the sporadic and genetic frontotemporal dementias Open
Background Frontotemporal dementia (FTD) is a common cause of young‐onset dementia, with promising disease‐modifying candidates. Cortical signatures are well established; however, comprehensive longitudinal investigations of subcortical at…
Correlation between quantitative and qualitative assessments of white matter hyperintensities in patients from a multicentric memory clinic population Open
Background White matter hyperintensities (WMH) can be visualized as abnormal T2 signal in the periventricular, deep and subcortical white matter on Magnetic Resonance Imaging (MRI). WMH increase with age and are associated with stroke, cog…
Four‐year cognitive decline in mild cognitive impairment patients with distinct baseline neuroanatomical atrophy profiles: A MEMENTO and QyScore® study Open
Background Neuroanatomical atrophy profile is increasingly recognised as a valuable characterisation in mild cognitive impairment (MCI) individuals and may provide prognostic information about cognitive decline. Method 1153 MCI participant…
Relationship between MTA visual scale scores and hippocampal volume measured by a medical device in patients from a multicentric memory clinic population Open
Background The medial temporal lobe (MTL), including the hippocampus, undergoes atrophy in patients with Alzheimer’s disease (AD). Visual rating of medial temporal lobe atrophy (MTA) is often performed in the assessment of patients with co…
Prevalence and clinical associations of atrophy subtypes using clinical routine image analysis software in MCI patients from a memory clinic population Open
Background Three patterns of brain atrophy have been consistently identified in cases of Alzheimer’s dementia [1]: a limbic‐predominant (LP) phenotype, with atrophy of the hippocampus but relatively spared neocortex; a hippocampal sparing …
Subcortical atrophy imaging biomarker performance across the sporadic and genetic frontotemporal dementias Open
Background Frontotemporal dementia (FTD) is a common cause of young‐onset dementia, with promising disease‐modifying candidates. Cortical signatures are well established; however, comprehensive longitudinal investigations of subcortical at…
View article: Comparative site-specific N-glycoproteome analysis reveals aberrant N-glycosylation andgives new insights into mannose-6-phosphate pathway in cancer
Comparative site-specific N-glycoproteome analysis reveals aberrant N-glycosylation andgives new insights into mannose-6-phosphate pathway in cancer Open
N-glycosylation is implicated in cancers and aberrant N-glycosylation is recognized as a hallmark of cancer. Here, we mapped and compared the site-specific N-glycoproteomes of colon cancer HCT116 cells and isogenic non-tumorigenic DNMT1/3b…
View article: Comparative analyses of the N-glycoproteomes in HCT116 cancer cells and their non-tumorigenic <i>DNMT1</i>/<i>3b</i> double knockout (DKO1) cells and insight into the Mannose-6-phosphate pathway
Comparative analyses of the N-glycoproteomes in HCT116 cancer cells and their non-tumorigenic <i>DNMT1</i>/<i>3b</i> double knockout (DKO1) cells and insight into the Mannose-6-phosphate pathway Open
N-glycoproteomic analyses provide valuable resources for investigation of cancer mechanisms, biomarkers, and therapeutic targets. Here, we mapped and compared the site-specific N-glycoproteomes of colon cancer HCT116 cells and isogenic non…
View article: Development of HEK-293 Cell Lines Constitutively Expressing Flaviviral Antigens for Use in Diagnostics
Development of HEK-293 Cell Lines Constitutively Expressing Flaviviral Antigens for Use in Diagnostics Open
Serological diagnostic testing for flaviviral infections is hindered by the need for specialized biocontainment for preparation of reagents and assay implementation. The use of previously developed COS-1 cell lines secreting noninfectious …
DAT negative warm autoimmune haemolytic anaemia secondary to a mature cystic teratoma refractory to immunosuppressive therapy Open
Mature cystic teratomas (MCTs) have a rare but recognised association with IgG-mediated autoimmune haemolytic anaemia (AIHA). We present the first case of an MCT associated with IgA-mediated AIHA. We discuss the diagnostic challenges of pa…
View article: Investigating the relationship between BMI across adulthood and late life brain pathologies
Investigating the relationship between BMI across adulthood and late life brain pathologies Open
Background In view of reported associations between high adiposity, particularly in midlife and late-life dementia risk, we aimed to determine associations between body mass index (BMI), and BMI changes across adulthood and brain structure…
Automated quantitative MRI volumetry reports support diagnostic interpretation in dementia: a multi-rater, clinical accuracy study Open
Objectives We examined whether providing a quantitative report (QReport) of regional brain volumes improves radiologists’ accuracy and confidence in detecting volume loss, and in differentiating Alzheimer’s disease (AD) and frontotemporal …