Sara Hestehave
YOU?
Author Swipe
View article: Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms
Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms Open
Chronic pain affects 20 to 30% of the population and imposes a significant socioeconomic burden as it is often accompanied by substantial emotional comorbidities such as anxiety and depression. Yet, the mechanisms underlying the interactio…
View article: Quinoline-Based Neuropilin-1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain
Quinoline-Based Neuropilin-1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain Open
Nociceptive pain, resulting from tissue injury or inflammation, affects a large portion of the global population. This type of pain is commonly treated by small molecules that are associated with a variety of drawbacks, including addiction…
View article: Systematic review and quantitative trend analysis of scientific quality in preclinical studies using rodent models of post-surgical pain
Systematic review and quantitative trend analysis of scientific quality in preclinical studies using rodent models of post-surgical pain Open
Post-operative pain management is crucial, yet remains a global healthcare challenge with many patients suffering from unexpectedly severe acute pain, leading to impaired recovery and chronic pain. Post-operative pain models are useful for…
View article: Stress, epigenetic remodeling and FKBP51: Pathways to chronic pain vulnerability
Stress, epigenetic remodeling and FKBP51: Pathways to chronic pain vulnerability Open
Chronic pain and post-traumatic stress disorder (PTSD) show striking similarities in their prevalence following injury and trauma respectively, with growing evidence suggesting shared vulnerability mechanisms, particularly through stress-r…
View article: Refining the adjuvant-induced rat model of monoarthritis by optimizing the induction volume and injection site
Refining the adjuvant-induced rat model of monoarthritis by optimizing the induction volume and injection site Open
Arthritis is a highly prevalent and disabling condition characterized by pathological joint-damage, clinical symptoms of pain and loss of normal joint function. Monoarthritis can be modelled in rodents via intraarticular injection of compl…
View article: C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models
C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models Open
Antagonists - such as Ziconotide and Gabapentin - of the CaV2.2 (N-type) calcium channels are used clinically as analgesics for chronic pain. However, their use is limited by narrow therapeutic windows, difficult dosing routes (Ziconotide)…
View article: Differences in multidimensional phenotype of 2 joint pain models link early weight-bearing deficit to late depressive-like behavior in male mice
Differences in multidimensional phenotype of 2 joint pain models link early weight-bearing deficit to late depressive-like behavior in male mice Open
Introduction: Chronic pain is a hallmark of joint diseases. Although these conditions are often accompanied by negative affective symptoms including depression and anxiety, these comorbidities are rarely studied simultaneously in preclinic…
View article: Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms
Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms Open
Chronic pain affects 20-30% of the population and imposes a significant socio-economic burden as it is often accompanied by substantial emotional comorbidities such as anxiety and depression. Yet, the mechanisms underlying the interactions…
View article: Small molecule targeting NaV1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model
Small molecule targeting NaV1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model Open
Osteoarthritis (OA) is a highly prevalent and disabling joint disease, characterized by pathological progressive joint deformation and clinical symptoms of pain. Disease-modifying treatments remain unavailable, and pain-mitigation is often…
View article: Uncoupling the CRMP2-Ca<sub>V</sub>2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model
Uncoupling the CRMP2-Ca<sub>V</sub>2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model Open
Osteoarthritis (OA) represents a significant pain challenge globally, as current treatments are limited and come with substantial and adverse side effects. Voltage-gated calcium channels have proved to be pharmacologically effective target…
View article: C–H Functionalization-Enabled 11-Step Semisynthesis of (−)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment
C–H Functionalization-Enabled 11-Step Semisynthesis of (−)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment Open
We report an efficient semisynthesis of the cholestane steroidal alkaloid (-)-veragranine A with a 6/6/6/5/6/6 hexacyclic ring system, eight stereocenters, and a unique C12-C23 linkage. Our synthesis features a Schönecker-Baran C-H oxidati…
View article: Predicting hypersensitivity and comorbid depressive-like behavior in late stages of joint disease using early weight bearing deficit
Predicting hypersensitivity and comorbid depressive-like behavior in late stages of joint disease using early weight bearing deficit Open
Chronic pain is a hallmark of joint diseases and is often accompanied by negative affective symptoms such as low mood, anxiety and memory dysfunction. Whether these may be the results of the more obvious sensory and functional symptoms of …
View article: A peptidomimetic modulator of the Ca <sub>V</sub> 2.2 N-type calcium channel for chronic pain
A peptidomimetic modulator of the Ca <sub>V</sub> 2.2 N-type calcium channel for chronic pain Open
Transmembrane Ca v 2.2 (N-type) voltage-gated calcium channels are genetically and pharmacologically validated, clinically relevant pain targets. Clinical block of Ca v 2.2 (e.g., with Prialt/Ziconotide) or indirect modulation [e.g., with …
View article: Hair glucocorticoids are not a historical marker of stress – Exploring the time-scale of corticosterone incorporation into hairs in a rat model
Hair glucocorticoids are not a historical marker of stress – Exploring the time-scale of corticosterone incorporation into hairs in a rat model Open
Hair glucocorticoids are increasingly popular biomarkers, used across numerous research fields, and studied species, as a measure of stress. Although they are suggested to be a proxy of the average HPA axis activity spanning a period of we…
View article: Reliability of sucrose preference testing following short or no food and water deprivation - a Systematic Review and Meta–Analysis of rat models of chronic unpredictable stress
Reliability of sucrose preference testing following short or no food and water deprivation - a Systematic Review and Meta–Analysis of rat models of chronic unpredictable stress Open
The sucrose preference test is a popular test for anhedonia in the chronic unpredictable stress model of depression. Yet, the test does not always produce consistent results. Long food and water deprivation before the test, while often imp…
View article: Effects of buprenorphine on acute pain and inflammation in the adjuvant-induced monoarthritis rat model
Effects of buprenorphine on acute pain and inflammation in the adjuvant-induced monoarthritis rat model Open
Buprenorphine, administered either subcutaneously or by voluntary ingestion, provides adequate analgesia for both sexes within the first 24 h post CFA-injection. Buprenorphine treatment improved clinical scores and appeared not to suppress…
View article: Effects of Transdermal Fentanyl Treatment on Acute Pain and Inflammation in Rats with Adjuvant-induced Monoarthritis
Effects of Transdermal Fentanyl Treatment on Acute Pain and Inflammation in Rats with Adjuvant-induced Monoarthritis Open
Eliminating unnecessary pain is an important requirement of performing animal experimentation, including reducing and controlling pain of animals used in pain research. The goal of this study was to refine an adjuvant-induced monoarthritis…
View article: Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain Open
Visceral pain is a prominent feature of various gastrointestinal diseases. The P2X7 receptor is expressed by multiple cell types including dorsal root ganglion satellite glial cells, macrophages and spinal microglia, all of which have been…
View article: Effects of buprenorphine on model development in an adjuvant-induced monoarthritis rat model
Effects of buprenorphine on model development in an adjuvant-induced monoarthritis rat model Open
Complete Freund’s adjuvant (CFA)-induced arthritis in rats is a common animal model for studying chronic inflammatory pain. However, modelling of the disease is associated with unnecessary pain and impaired animal wellbeing, particularly i…
View article: Hair glucocorticoids are not a historical marker of stress – exploring the time-scale of corticosterone incorporation into hairs in a rat model
Hair glucocorticoids are not a historical marker of stress – exploring the time-scale of corticosterone incorporation into hairs in a rat model Open
Hair glucocorticoids are increasingly popular biomarkers, used across numerous research fields as a measure of stress. Although they are suggested to be a proxy of the average HPA axis activity spanning a period of weeks or months into the…
View article: Stress sensitivity and cutaneous sensory thresholds before and after neuropathic injury in various inbred and outbred rat strains
Stress sensitivity and cutaneous sensory thresholds before and after neuropathic injury in various inbred and outbred rat strains Open
Chronic pain is associated with altered affective state, stress, anxiety and depression. Conversely, stress, anxiety and depression can all modulate pain perception. The relative link between these behavioural constructs in different inbre…
View article: The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery
The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery Open
Background Translating efficacy of analgesic drugs from animal models to humans remains challenging. Reasons are multifaceted, but lack of sufficiently rigorous preclinical study design criteria and phenotypically relevant models may be pa…
View article: Is there a reasonable excuse for not providing post-operative analgesia when using animal models of peripheral neuropathic pain for research purposes?
Is there a reasonable excuse for not providing post-operative analgesia when using animal models of peripheral neuropathic pain for research purposes? Open
Post-operative analgesia does not appear to affect established neuropathic hypersensitivity outcome in the SNI model.