Sara J Cayaban
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View article: Design of multi-target peptide modulators for protein chaperone networks
Design of multi-target peptide modulators for protein chaperone networks Open
Essential chaperones heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90) collaborate in oncoprotein folding. Dual inhibition of these chaperones has shown synergy in preclinical studies but remains challenging to achieve. Using…
View article: Integrating deep learning for post-translational modifications crosstalk on Hsp90 and drug binding
Integrating deep learning for post-translational modifications crosstalk on Hsp90 and drug binding Open
Post-translational modification (PTM) of proteins regulates cellular proteostasis by expanding protein functional diversity. This naturally leads to increased proteome complexity as a result of PTM crosstalk. Here, we used the molecular ch…