Sara Jenks
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View article: Clinical Decisions and Outcomes After Switching High-Sensitivity Cardiac Troponin Assays in Suspected ACS
Clinical Decisions and Outcomes After Switching High-Sensitivity Cardiac Troponin Assays in Suspected ACS Open
Importance High-sensitivity cardiac troponin T and I assays are considered equivalent for the diagnosis of myocardial infarction. However, the impact of transitioning from an assay measuring cardiac troponin I to one measuring cardiac trop…
View article: Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID
Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID Open
Even within a single protein, antibody binding can have beneficial, neutral, or harmful effects during the response to infection. Resolving a polyclonal antibody repertoire across a pathogen’s proteome to specific epitopes may therefore ex…
View article: Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID
Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID Open
Even within a single protein, antibody binding can have beneficial, neutral, or harmful effects during the response to infection. Resolving a polyclonal antibody repertoire across a pathogen’s proteome to specific epitopes may therefore ex…
View article: Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID
Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID Open
Even within a single protein, antibody binding can have beneficial, neutral, or harmful effects during the response to infection. Resolving a polyclonal antibody repertoire across a pathogen’s proteome to specific epitopes may therefore ex…
View article: 61 Impact of patient selection on performance of an early rule-out pathway for myocardial infarction: from research to the real world
61 Impact of patient selection on performance of an early rule-out pathway for myocardial infarction: from research to the real world Open
Background Early rule-out pathways for myocardial infarction using high-sensitivity cardiac troponin are widely recommended in the assessment of patients with suspected acute coronary syndrome. Although developed in selected patients parti…
View article: Evaluation of SARS-CoV-2 antibody point of care devices in the laboratory and clinical setting
Evaluation of SARS-CoV-2 antibody point of care devices in the laboratory and clinical setting Open
SARS-CoV-2 antibody tests have been marketed to diagnose previous SARS-CoV-2 infection and as a test of immune status. There is a lack of evidence on the performance and clinical utility of these tests. We aimed to carry out an evaluation …
View article: 290 ‘Save Blood' - Strategies to Reduce Inappropriate Routine Bloods Tests in a Surgical Department
290 ‘Save Blood' - Strategies to Reduce Inappropriate Routine Bloods Tests in a Surgical Department Open
Aim To quantify the number of inappropriate blood tests in our 72-bed Surgical Department and identify strategies that reduce the number of unnecessary electronic blood test requests. This should reduce patient harm, demands on staff time,…
View article: Evaluation of SARS-CoV-2 Antibody Point of Care Devices in the Laboratory and Clinical Setting
Evaluation of SARS-CoV-2 Antibody Point of Care Devices in the Laboratory and Clinical Setting Open
SARS-CoV-2 Antibody tests have been marketed to diagnose previous SARS-CoV-2 infection and as a test of immune status. There is a lack of evidence on the performance and clinical utility of these tests. We aimed to carry out an evaluation …
View article: Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: implications for the ability of serological assays to predict immunity
Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: implications for the ability of serological assays to predict immunity Open
Background Serological assays are being deployed to monitor antibody responses in SARS-CoV-2 convalescents and vaccine recipients. There is a need to determine whether such assays can predict immunity, as antibody levels wane and viral var…
View article: Comparison of SARS-CoV-2 serological assays for use in epidemiological surveillance in Scotland
Comparison of SARS-CoV-2 serological assays for use in epidemiological surveillance in Scotland Open
Background Sero-surveillance of SARS-CoV-2 is crucial to monitoring levels of population exposure and informing public health responses, but may be influenced by variability in performance between available assays. Methods Five commercial …
View article: Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection
Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera From Individuals With Recent Seasonal Coronavirus Infection Open
Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepa…
View article: Report 34: COVID-19 infection fatality ratio: estimates from seroprevalence
Report 34: COVID-19 infection fatality ratio: estimates from seroprevalence Open
The infection fatality ratio (IFR) is a key statistic for estimating the burden of coronavirus disease 2019 (COVID-19) and has been continuously debated throughout the current pandemic. Previous estimates have relied on data early in the e…
View article: Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients
Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients Open
Background Understanding the longitudinal trajectory of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is crucial for diagnosis of prior infection and predicting future immunity. Methods We conducted a longitudinal…
View article: Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection
Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection Open
Cross-reactive immune responses elicited by seasonal coronaviruses might impact SARS-CoV-2 susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in pre-pandemic sera from patients with prior PCR-confirme…
View article: Diagnostic performance of the combined nasal and throat swab in patients admitted to hospital with suspected COVID-19
Diagnostic performance of the combined nasal and throat swab in patients admitted to hospital with suspected COVID-19 Open
Background Accurate diagnosis in patients with suspected coronavirus disease 2019 (COVID-19) is essential to guide treatment and limit spread of the virus. The combined nasal and throat swab is used widely, but its diagnostic performance i…
View article: Longitudinal analysis of clinical serology assay performance and neutralising antibody levels in COVID19 convalescents
Longitudinal analysis of clinical serology assay performance and neutralising antibody levels in COVID19 convalescents Open
Objectives To investigate longitudinal trajectory of SARS-CoV-2 neutralising antibodies and the performance of serological assays in diagnosing prior infection and predicting serum neutralisation titres with time Design Retrospective longi…
View article: Alpha-Fetoprotein Detection of Hepatocellular Carcinoma Leads to a Standardized Analysis of Dynamic AFP to Improve Screening Based Detection
Alpha-Fetoprotein Detection of Hepatocellular Carcinoma Leads to a Standardized Analysis of Dynamic AFP to Improve Screening Based Detection Open
Detection of hepatocellular carcinoma (HCC) through screening can improve outcomes. However, HCC surveillance remains costly, cumbersome and suboptimal. We tested whether and how serum Alpha-Fetoprotein (AFP) should be used in HCC surveill…