Sara Luzzi
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View article: The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer
The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer Open
Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cancer have failed to elicit durable clinica…
View article: Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells
Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells Open
Background Atherosclerosis develops at arterial sites exposed to disturbed flow, while plaque rupture and plaque erosion predominantly occur in regions subjected to elevated flow. The impact of elevated flow on regulation of endothelial ge…
View article: Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer
Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer Open
Resistance to androgen receptor (AR)–targeted therapies represents a major challenge in prostate cancer. A key mechanism of treatment resistance in patients who progress to castration-resistant prostate cancer (CRPC) is the generation of a…
View article: An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression
An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression Open
Previously, we showed that the germ cell-specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility (Ehrmann et al., 2019). Here, we show that in somatic cells the similar yet ubiq…
View article: An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression
An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression Open
We previously showed that the germ cell specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility. RBMXL2 evolved from the X-linked RBMX gene, which is silenced during meiosis due…
View article: An anciently diverged family of RNA binding proteins maintain correct splicing of ultra-long exons through cryptic splice site repression
An anciently diverged family of RNA binding proteins maintain correct splicing of ultra-long exons through cryptic splice site repression Open
We previously showed that the germ cell specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility. It has remained unknown whether RBMXL2 evolved its role in splicing repression t…
View article: Reviewer #2 (Public Review): An anciently diverged family of RNA binding proteins maintain correct splicing of ultra-long exons through cryptic splice site repression
Reviewer #2 (Public Review): An anciently diverged family of RNA binding proteins maintain correct splicing of ultra-long exons through cryptic splice site repression Open
We previously showed that the germ cell specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility. It has remained unknown whether RBMXL2 evolved its role in splicing repression t…
View article: Reviewer #1 (Public Review): An anciently diverged family of RNA binding proteins maintain correct splicing of ultra-long exons through cryptic splice site repression
Reviewer #1 (Public Review): An anciently diverged family of RNA binding proteins maintain correct splicing of ultra-long exons through cryptic splice site repression Open
We previously showed that the germ cell specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility. It has remained unknown whether RBMXL2 evolved its role in splicing repression t…
View article: An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression
An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression Open
Previously, we showed that the germ cell-specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility (Ehrmann et al., 2019). Here, we show that in somatic cells the similar yet ubiq…
View article: Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer
Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer Open
Prostate cancer progression is connected to the activity of conventional oncogenes and tumour suppressors and driven by circulating steroid hormones. A key issue has been how to identify and care for aggressively developing prostate tumour…
View article: The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer
The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer Open
Aberrant androgen receptor (AR) signaling drives prostate cancer (PC), and it is a key therapeutic target. Although initially effective, the generation of alternatively spliced AR variants (AR-Vs) compromises efficacy of treatments. In con…
View article: An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression
An anciently diverged family of RNA binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression Open
We previously showed that the germ cell specific nuclear protein RBMXL2 represses cryptic splicing patterns during meiosis and is required for male fertility. RBMXL2 evolved from the X-linked RBMX gene, which is silenced during meiosis due…
View article: Cryptic splicing: common pathological mechanisms involved in male infertility and neuronal diseases
Cryptic splicing: common pathological mechanisms involved in male infertility and neuronal diseases Open
High levels of transcription and alternative splicing are recognized hallmarks of gene expression in the testis and largely driven by cells in meiosis. Because of this, the male meiosis stage of the cell cycle is often viewed as having a r…
View article: RBMX enables productive RNA processing of ultra-long exons important for genome stability
RBMX enables productive RNA processing of ultra-long exons important for genome stability Open
Previously we showed that the germline-specific RNA binding protein RBMXL2 is essential for male meiosis where it represses cryptic splicing patterns (1). Here we find that its ubiquitously expressed paralog RBMX helps underpin human genom…
View article: The INO80 ATP-dependent chromatin remodelling complex alleviates stalled Polymerase II to promote non-coding RNA transcription termination
The INO80 ATP-dependent chromatin remodelling complex alleviates stalled Polymerase II to promote non-coding RNA transcription termination Open
Co-transcriptional RNA quality control is essential for gene expression. However, its regulation remains poorly understood. Here, we report that the evolutionarily conserved ATP-dependent chromatin remodelling INO80 complex promotes transc…