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View article: Hepatitis C epidemiology and treatment outcomes in Italy: Impact of the <scp>DAA</scp> era and the <scp>COVID</scp>‐19 pandemic
Hepatitis C epidemiology and treatment outcomes in Italy: Impact of the <span>DAA</span> era and the <span>COVID</span>‐19 pandemic Open
HCV infection poses a global health threat, with significant morbidity and mortality. This study examines HCV trends in a large Italian region from 2015 to 2022, considering demographic changes, evolving clinical profiles, treatment regime…
View article: Safety and Efficacy of Outpatient Treatments for COVID-19: Real-Life Data from a Regionwide Cohort of High-Risk Patients in Tuscany, Italy (the FEDERATE Cohort)
Safety and Efficacy of Outpatient Treatments for COVID-19: Real-Life Data from a Regionwide Cohort of High-Risk Patients in Tuscany, Italy (the FEDERATE Cohort) Open
Early COVID-19 treatments can prevent progression to severe disease. However, real-life data are still limited, and studies are warranted to monitor the efficacy and tolerability of these drugs. We retrospectively enrolled outpatients rece…
View article: Effectiveness of integrase strand transfer inhibitors in HIV‐infected treatment‐experienced individuals across Europe
Effectiveness of integrase strand transfer inhibitors in HIV‐infected treatment‐experienced individuals across Europe Open
Objectives To explore the effectiveness and durability of integrase strand transfer inhibitor (INSTI)‐based regimens in pre‐treated subjects. Methods Treatment‐experienced individuals starting an INSTI‐based regimen during 2012–2019 were s…
View article: Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia
Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia Open
ClinicalTrials.gov Identifier: NCT04716556.
View article: Effectiveness of integrase strand transfer inhibitor-based regimens in HIV-infected treatment-naive individuals: results from a European multi-cohort study
Effectiveness of integrase strand transfer inhibitor-based regimens in HIV-infected treatment-naive individuals: results from a European multi-cohort study Open
Background INSTIs have become a pillar of first-line ART. Real-world data are needed to assess their effectiveness in routine care. Objectives We analysed ART-naive patients who started INSTI-based regimens in 2012–19 whose data were colle…
View article: Simplification to High Genetic Barrier 2-Drug Regimens in People Living With HIV Harboring 4-Class Resistance Enrolled in the PRESTIGIO Registry
Simplification to High Genetic Barrier 2-Drug Regimens in People Living With HIV Harboring 4-Class Resistance Enrolled in the PRESTIGIO Registry Open
To the Editors: Today, most people living with HIV (PLWH) with access to ART successfully achieve virological suppression. Nevertheless, many efforts are still needed to face unsolved problems such as drug resistance (HIVDR), antiretrovira…
View article: Impact of Antiretroviral Therapy on the Risk of Recurrence in HIV-1 Infected Patients with Kaposi Sarcoma: A Multicenter Cohort Experience
Impact of Antiretroviral Therapy on the Risk of Recurrence in HIV-1 Infected Patients with Kaposi Sarcoma: A Multicenter Cohort Experience Open
Kaposi sarcoma (KS) remains a relevant malignancy in human immunodeficiency virus (HIV)-infected patients with a non-standardized management; despite past suggestions that ritonavir-boosted protease inhibitor (bPI)-based regimens could be …
View article: Predicting 2-drug antiretroviral regimen efficacy by genotypic susceptibility score: results from a cohort study
Predicting 2-drug antiretroviral regimen efficacy by genotypic susceptibility score: results from a cohort study Open
Background: HIV drug resistance has a deleterious effect on the virological outcome of antiretroviral therapy (ART). The aim of the study was to evaluate the ability of genotypic susceptibility score (GSS) to predict virological outcome fo…
View article: Prevalence and determinants of resistance mutations in <scp>HIV</scp>‐1‐infected patients exposed to integrase inhibitors in a large Italian cohort
Prevalence and determinants of resistance mutations in <span>HIV</span>‐1‐infected patients exposed to integrase inhibitors in a large Italian cohort Open
Objectives The aim of the study was to analyse the prevalence of integrase resistance mutations in integrase strand transfer inhibitor ( INSTI )‐experienced HIV ‐1‐infected patients and its predictors. Methods We selected HIV ‐1 integrase …