Sara Oliván
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Cubosomes-active carriers in chemotherapy modern medicine Open
Cubosomes are lipid vesicles that are comparable to vesicular systems like liposomes. Cubosomes are created with certain amphiphilic lipids in the presence of a suitable stabilizer. Since its discovery and designation, self-assembled cubos…
Impact of Front-Line Demonstrations of Azotobacter in Wheat in Karji Village, District of Kaimur, Bihar, India Open
Wheat is the world's most widely cultivated food crop after rice, and it is utilised in various forms by more than a billion people in the world, being a staple food for a large population, contributing about 20% of humans' daily dietary c…
Beyond Barriers: Redefining Organ-on-Chip Architecture Through Emerging Designs Open
This study presents four barrier-free organ-on-chip devices using xurography, thermal bonding, and surface treatment for hydrogel confinement. Removing physical barriers enhanced cellular interaction. Devices were tailored for hypoxia, tum…
View article: A Novel Multicompartment Barrier‐Free Microfluidic Device Reveals the Impact of Extracellular Matrix Stiffening and Temozolomide on Immune‐Tumor Interactions in Glioblastoma
A Novel Multicompartment Barrier‐Free Microfluidic Device Reveals the Impact of Extracellular Matrix Stiffening and Temozolomide on Immune‐Tumor Interactions in Glioblastoma Open
The immune system plays a crucial role in shaping the glioblastoma tumor microenvironment, characterized by its complexity and dynamic interactions. Understanding the tumor‐immune crosstalk is essential for advancing cancer research and th…
View article: Improving Cell-to-Cell and Cell-to-Matrix Contact inside Microphysiological Systems
Improving Cell-to-Cell and Cell-to-Matrix Contact inside Microphysiological Systems Open
Innovative microfluidic technology aims to create more realistic in vitro simulations of human tissues. Organ-on-a-chip (OoC) devices within microfluidic chips mimic in vivo environments but face limitations due to inert material between c…
View article: Reducing Inert Materials for Optimal Cell–Cell and Cell–Matrix Interactions within Microphysiological Systems
Reducing Inert Materials for Optimal Cell–Cell and Cell–Matrix Interactions within Microphysiological Systems Open
In the pursuit of achieving a more realistic in vitro simulation of human biological tissues, microfluidics has emerged as a promising technology. Organ-on-a-chip (OoC) devices, a product of this technology, contain miniature tissues withi…
View article: In Vitro Growth of Human Follicles: Current and Future Perspectives
In Vitro Growth of Human Follicles: Current and Future Perspectives Open
Ovarian tissue cryopreservation is gaining importance as a successful method to restore fertility to girls and young women at high risk of sterility. However, there are concerns regarding the safety of transplantation after ovarian tissue …
View article: A microphysiological system for handling graphene related materials under flow conditions
A microphysiological system for handling graphene related materials under flow conditions Open
A kidney-on-a-chip has been developed and optimised to evaluate the effects of exposure to graphene related materials under fluid flow conditions.
View article: Tuneable hydrogel patterns in pillarless microfluidic devices
Tuneable hydrogel patterns in pillarless microfluidic devices Open
A novel methodology utilizing plasma surface treatment enables the construction of cell culture chambers featuring abutment-free patterns, facilitating the precise distribution of shear stress.
View article: Performance in Kahoot! activities as predictive of exam performance
Performance in Kahoot! activities as predictive of exam performance Open
Background Game-based learning (GBL) is effective for increasing participation, creativity, and student motivation. However, the discriminative value of GBL for knowledge acquisition has not yet been proven. The aim of this study is to ass…
View article: Towards Novel Biomimetic In Vitro Models of the Blood–Brain Barrier for Drug Permeability Evaluation
Towards Novel Biomimetic In Vitro Models of the Blood–Brain Barrier for Drug Permeability Evaluation Open
Current available animal and in vitro cell-based models for studying brain-related pathologies and drug evaluation face several limitations since they are unable to reproduce the unique architecture and physiology of the human blood–brain …
Cold-shock proteins accumulate in centrosomes and their expression and primary cilium morphology are regulated by hypothermia and shear stress Open
Primary cilia act as cellular sensors for multiple extracellular stimuli and regulate many intracellular signaling pathways in response. Here we investigate whether the cold-shock proteins (CSPs), CIRP and RBM3, are present in the primary …
Novel Fabrication Technique to Confine Hydrogels with Different Patterns inside Microfluidic Devices without Pillars Open
In the field of microtechnologies applied to the simulation of controlled biological environments are the so-called organ-on-a-chip, microfluidic cell culture devices. The gradient model plays an indispensable role in this technology. Here…
Mathematical formulation and parametric analysis of in vitro cell models in microfluidic devices: application to different stages of glioblastoma evolution Open
In silico models and computer simulation are invaluable tools to better understand complex biological processes such as cancer evolution. However, the complexity of the biological environment, with many cell mechanisms in response to chang…
Author Correction: Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Activated human primary NK cells efficiently kill colorectal cancer cells in 3D spheroid cultures irrespectively of the level of PD-L1 expression Open
Haploidentical Natural Killer (NK) cells have been shown as an effective and safe alternative for the treatment of haematological malignancies with poor prognosis for which traditional therapies are ineffective. In contrast to haematologic…
View article: New Structured Materials in the Study of the Mechanobiological Processes Related to the Heart Failure
New Structured Materials in the Study of the Mechanobiological Processes Related to the Heart Failure Open
Cardiovascular diseases are the number one of death globally. According to the World Health organization 17.7 million people died from cardiovascular diseases in 2015, representing 31% of all global deaths. In these diseases the cardiac ho…
Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy Open
Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. SMA is associated with reduced levels of full-length Survival of Motor Neuron …