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View article: Unique Genetic and Epigenetic Alterations in Glioblastoma Long‐Term Survivors: Insights From Two Clinical Cases
Unique Genetic and Epigenetic Alterations in Glioblastoma Long‐Term Survivors: Insights From Two Clinical Cases Open
The biological mechanisms driving the long survival in glioblastoma (GBM). Five‐year long‐term survival (LTS) and 10‐year survival very long‐term survival (VLTS) remain significantly understudied. Here we molecularly detailed two cases. AR…
View article: Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target
Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target Open
View article: <scp>EGFR</scp>‐<scp>KDD</scp> Myofibroblastic Neoplasm or Congenital Peribronchial Myofibroblastic Tumor (<scp>CPMT</scp>)? Report of a Congenital Myofibroblastic Neoplasm With Unusual Histologic Features
<span>EGFR</span>‐<span>KDD</span> Myofibroblastic Neoplasm or Congenital Peribronchial Myofibroblastic Tumor (<span>CPMT</span>)? Report of a Congenital Myofibroblastic Neoplasm With Unusual Histologic Features Open
EGFR‐kinase‐domain duplication (KDD) has been reported in Infantile fibrosarcoma‐like myofibroblastic tumors and cellular mesoblastic nephroma. We report a pulmonary neoplasm with EGFR‐(KDD) and infantile fibrosarcoma‐like histologic featu…
View article: An 11‐year‐old boy with a posterior fossa tumor
An 11‐year‐old boy with a posterior fossa tumor Open
View article: Quantification of tumour-infiltrating immune cells through deconvolution of DNA methylation data in Ewing sarcomas
Quantification of tumour-infiltrating immune cells through deconvolution of DNA methylation data in Ewing sarcomas Open
Ewing Sarcomas (EWS, OMIM # 612219) presents a major challenge in pediatric oncology due to its aggressive nature and poor prognosis, particularly in metastatic cases. Genetic fusions involving the EWSR1 gene and ETS family transcription f…
View article: METB-10. GENOME-WIDE DNA METHYLATION PROFILING OF PRIMARY CELLS FROM PEDIATRIC BRAIN TUMORS IS AN INFORMATIVE TOOL TO ASSESS CELL CULTURE RELIABILITY AND IN VITRO SELECTION
METB-10. GENOME-WIDE DNA METHYLATION PROFILING OF PRIMARY CELLS FROM PEDIATRIC BRAIN TUMORS IS AN INFORMATIVE TOOL TO ASSESS CELL CULTURE RELIABILITY AND IN VITRO SELECTION Open
BACKGROUND Recent genomic and epigenomic profiling analyses have provided remarkable insights into biology of pediatric brain tumors (pBTs). Nonetheless, pBTs represent the deadliest childhood cancer worldwide and are associated with high …
View article: Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling
Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling Open
View article: PATZ1-Rearranged Tumors of the Central Nervous System: Characterization of a Pediatric Series of Seven Cases
PATZ1-Rearranged Tumors of the Central Nervous System: Characterization of a Pediatric Series of Seven Cases Open
View article: EPCO-02. GENOME-WIDE DNA METHYLATION PROFILING AND GENETIC CHARACTERIZATION OF LONG-TERM SURVIVAL IDH WILD-TYPE GLIOBLASTOMA PATIENTS
EPCO-02. GENOME-WIDE DNA METHYLATION PROFILING AND GENETIC CHARACTERIZATION OF LONG-TERM SURVIVAL IDH WILD-TYPE GLIOBLASTOMA PATIENTS Open
Glioblastoma multiforme (GBM) has a dismal outcome of approximately 12 months. Less than 5% of patients (long-term survivors-LTS) survives more than 5-years, including IDH-mutant gliomas. Nevertheless, the molecular fingerprint of LTS rema…
View article: Whole-Genome Methylation Study of Congenital Lung Malformations in Children
Whole-Genome Methylation Study of Congenital Lung Malformations in Children Open
Background and Objectives The treatment of asymptomatic patients with congenital pulmonary malformations (CPMs) remains controversial, partially because the relationship between congenital lung malformations and malignancy is still undefin…