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View article: Targeting Glioblastoma Tumor Hyaluronan to Enhance Therapeutic Interventions that Regulate Metabolic Cell Properties
Targeting Glioblastoma Tumor Hyaluronan to Enhance Therapeutic Interventions that Regulate Metabolic Cell Properties Open
Despite extensive advances in cancer research, glioblastoma (GBM) still remains a very locally invasive and thus challenging tumor to treat, with a poor median survival. Tumor cells remodel their microenvironment and utilize extracellular …
View article: The effect of BMI and type 2 diabetes on socioeconomic status: a two-sample multivariable Mendelian randomization study
The effect of BMI and type 2 diabetes on socioeconomic status: a two-sample multivariable Mendelian randomization study Open
OBJECTIVE To assess the independent causal effect of BMI and type 2 diabetes (T2D) on socioeconomic outcomes applying two-sample Mendelian randomization (MR) analysis. RESEARCH DESIGN AND METHODS We carried out univariate and multivariate …
View article: The effect of BMI and type 2 diabetes on socioeconomic status: a two-sample multivariable Mendelian randomization study
The effect of BMI and type 2 diabetes on socioeconomic status: a two-sample multivariable Mendelian randomization study Open
OBJECTIVE To assess the independent causal effect of BMI and type 2 diabetes (T2D) on socioeconomic outcomes applying two-sample Mendelian randomization (MR) analysis. RESEARCH DESIGN AND METHODS We carried out univariate and multivariate …
View article: Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels
Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels Open
Three-dimensional cultures have exciting potential to mimic aspects of healthy and diseased brain tissue to examine the role of physiological conditions on neural biomarkers as well as disease onset and progression. Hypoxia is associated w…
View article: Rheological Analysis of the Gelation Kinetics of an Enzyme Cross-linked PEG Hydrogel
Rheological Analysis of the Gelation Kinetics of an Enzyme Cross-linked PEG Hydrogel Open
The diverse requirements of hydrogels for tissue engineering motivate the development of cross-linking reactions to fabricate hydrogel networks with specific features, particularly those amenable to the activity of biological materials (e.…
View article: Editorial: Biomaterials for Brain Therapy and Repair
Editorial: Biomaterials for Brain Therapy and Repair Open
EDITORIAL article Front. Mater., 15 November 2018Sec. Biomaterials Volume 5 - 2018 | https://doi.org/10.3389/fmats.2018.00067
View article: The Feasibility of Encapsulated Embryonic Medullary Reticular Cells to Grow and Differentiate Into Neurons in Functionalized Gelatin-Based Hydrogels
The Feasibility of Encapsulated Embryonic Medullary Reticular Cells to Grow and Differentiate Into Neurons in Functionalized Gelatin-Based Hydrogels Open
The study of the behavior of embryonic neurons in controlled in vitro conditions require methodologies that take advantage of advanced tissue engineering approaches to replicate elements of the developing brain extracellular matrix. We rep…
View article: Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior
Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior Open
The extracellular matrix (ECM) is critical in tumor growth and invasive potential of cancer cells. In glioblastoma tumors, some components of the native brain ECM such as hyaluronic acid (HA) have been suggested as key regulators of proces…
View article: Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior
Influence of hyaluronic acid transitions in tumor microenvironment on glioblastoma malignancy and invasive behavior Open
The extracellular matrix (ECM) is critical in tumor growth and invasive potential of cancer cells. In glioblastoma tumors, some components of the native brain ECM such as hyaluronic acid (HA) have been suggested as key regulators of proces…
View article: Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma
Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma Open
3D biomaterial models have potential to explore the influence of the tumor microenvironment on aberrant signaling pathways and compensatory signals using patient‐derived cells. Glioblastoma (GBM) tumors are highly heterogeneous, with both …
View article: The Combined Influence of Hydrogel Stiffness and Matrix‐Bound Hyaluronic Acid Content on Glioblastoma Invasion
The Combined Influence of Hydrogel Stiffness and Matrix‐Bound Hyaluronic Acid Content on Glioblastoma Invasion Open
Glioblastoma (GBM) is the most common and lethal form of brain cancer. Its high mortality is associated with its aggressive invasion throughout the brain. The heterogeneity of stiffness and hyaluronic acid (HA) content within the brain mak…
View article: Patterning Three-Dimensional Hydrogel Microenvironments Using Hyperbranched Polyglycerols for Independent Control of Mesh Size and Stiffness
Patterning Three-Dimensional Hydrogel Microenvironments Using Hyperbranched Polyglycerols for Independent Control of Mesh Size and Stiffness Open
The extracellular matrix is an environment rich with structural, mechanical, and molecular signals that can impact cell biology. Traditional approaches in hydrogel biomaterial design often rely on modifying the concentration of cross-linki…
View article: Correction: Nanoscale mechanics guides cellular decision making
Correction: Nanoscale mechanics guides cellular decision making Open
Correction for ‘Nanoscale mechanics guides cellular decision making’ by Zainab Rahil et al., Integr. Biol., 2016, DOI: 10.1039/c6ib00113k.
View article: Nanoscale mechanics guides cellular decision making
Nanoscale mechanics guides cellular decision making Open
Nanoscale tension gauges revealed how substrate stiffness alters pico Newton force thresholds that trigger initial cell attachment, spreading, and adhesion maturation.
View article: Hydrogels: Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment (Adv. Mater. 9/2015)
Hydrogels: Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment (Adv. Mater. 9/2015) Open
The tumor microenvironment in the brain is complex, varying in space and time. On page 1567, B. A. Harley and co-workers report the use of microfluidic forming tools to generate optically translucent hydrogels that contain overlapping grad…