Sara R. Zwart
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View article: Effects of hypoxia/hyperoxia exposure on immune function – results from a spacecraft-relevant hypobaric chamber study
Effects of hypoxia/hyperoxia exposure on immune function – results from a spacecraft-relevant hypobaric chamber study Open
Introduction Although the International Space Station provides a normoxic environment, deep space missions are expected to leverage a hypobaric, mildly hypoxic living environment to facilitate frequent extravehicular activities EVAs, aka s…
View article: Recovery of bone microarchitecture and density four years after spaceflight: two case studies
Recovery of bone microarchitecture and density four years after spaceflight: two case studies Open
View article: Nematodes in golf courses—Not all bad news!
Nematodes in golf courses—Not all bad news! Open
Knowledge about nematodes prevailing in thatch and soil layers of golf courses in South Africa is limited, with previous studies only focusing on plant‐parasitic nematode (PPN) abundance and diversity. Therefore, the present study was cond…
View article: Arterial structure and function in the years after long-duration spaceflight
Arterial structure and function in the years after long-duration spaceflight Open
Previous investigations focused on in- and immediate postflight cardiovascular health indices. Here we report that in the 5 years after long-duration spaceflight in low Earth orbit, there was no evidence of increased carotid artery intima-…
View article: Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans
Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans Open
Mechanical unloading causes bone loss, but it remains unclear whether disuse-induced changes to bone microstructure are permanent or can be recovered upon reloading. We examined bone loss and recovery in 17 astronauts using time-lapsed hig…
View article: Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology Open
View article: Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction Open
View article: Severe Spaceflight-Associated Neuro-Ocular Syndrome in an Astronaut With 2 Predisposing Factors
Severe Spaceflight-Associated Neuro-Ocular Syndrome in an Astronaut With 2 Predisposing Factors Open
Importance Understanding potential predisposing factors associated with spaceflight-associated neuro-ocular syndrome (SANS) may influence its management. Objective To describe a severe case of SANS associated with 2 potentially predisposin…
View article: A Mouse Model of Spaceflight Associated Neuro-ocular Syndrome Using One-Carbon Genetics
A Mouse Model of Spaceflight Associated Neuro-ocular Syndrome Using One-Carbon Genetics Open
Objectives: Spaceflight Associated Neuro-ocular Syndrome (SANS) includes an array of ophthalmic and neurologic signs and symptoms observed in a subset of astronauts after prolonged spaceflight. The etiology of these changes remains unknown…
View article: Spaceflight Associated Neuro-Ocular Syndrome in a Predisposed Astronaut With B-Vitamin Supplementation as a Potential Countermeasure
Spaceflight Associated Neuro-Ocular Syndrome in a Predisposed Astronaut With B-Vitamin Supplementation as a Potential Countermeasure Open
View article: Spatiotemporal expression and control of haemoglobin in space
Spatiotemporal expression and control of haemoglobin in space Open
It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, wi…
View article: Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight Open
Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found …
View article: Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction Open
Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplor…
View article: The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank Open
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space 1–6 . Yet current framework…
View article: Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology Open
View article: Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station
Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station Open
View article: Optic disc edema during strict 6° head-down tilt bed rest is related to one-carbon metabolism pathway genetics and optic cup volume
Optic disc edema during strict 6° head-down tilt bed rest is related to one-carbon metabolism pathway genetics and optic cup volume Open
Some astronauts on International Space Station missions experience neuroophthalmological pathologies as part of spaceflight associated neuro-ocular syndrome (SANS). Strict head-down tilt bed rest (HDTBR) is a spaceflight analog that replic…
View article: Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function
Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function Open
Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplor…
View article: Time-resolved molecular measurements reveal changes in astronauts during spaceflight
Time-resolved molecular measurements reveal changes in astronauts during spaceflight Open
From the early days of spaceflight to current missions, astronauts continue to be exposed to multiple hazards that affect human health, including low gravity, high radiation, isolation during long-duration missions, a closed environment an…
View article: P11-057-23 Genetics of One-Carbon Metabolism Are Associated With Optic Disc Edema in a Ground-Based Model of Spaceflight
P11-057-23 Genetics of One-Carbon Metabolism Are Associated With Optic Disc Edema in a Ground-Based Model of Spaceflight Open
View article: PTFS12-03-23 Iron Metabolism in Spaceflight-analogs
PTFS12-03-23 Iron Metabolism in Spaceflight-analogs Open
View article: Spatiotemporal Expression and Control of Haemoglobin in Space
Spatiotemporal Expression and Control of Haemoglobin in Space Open
The role of the space environment in activating a diverse set of genes involved in regulating key cellular pathways is now widely recognized. This includes genes associated with blood control and erythropoiesis, with a particular emphasis …
View article: Effects of antioxidant supplementation on bone mineral density, bone mineral content and bone structure in healthy men during 60 days of 6° head‐down tilt bed rest: Results from a randomised controlled trial
Effects of antioxidant supplementation on bone mineral density, bone mineral content and bone structure in healthy men during 60 days of 6° head‐down tilt bed rest: Results from a randomised controlled trial Open
Dietary countermeasures to mitigate detrimental spaceflight‐induced effects on bone health would alleviate the requirements and the consequences imposed by other types of countermeasures for this risk. We hypothesised that antioxidant supp…
View article: Time-resolved molecular measurements reveal changes in astronauts during spaceflight
Time-resolved molecular measurements reveal changes in astronauts during spaceflight Open
From the early days of spaceflight to current missions, astronauts continue to be exposed to multiple hazards that affect human health, including low gravity, high radiation, isolation during long-duration missions, a closed environment an…
View article: More than a Feeling: Dermatological Changes Impacted by Spaceflight
More than a Feeling: Dermatological Changes Impacted by Spaceflight Open
View article: Bone metabolism during strict head-down tilt bed rest and exposure to elevated levels of ambient CO2
Bone metabolism during strict head-down tilt bed rest and exposure to elevated levels of ambient CO2 Open
View article: Impact of diet on human nutrition, immune response, gut microbiome, and cognition in an isolated and confined mission environment
Impact of diet on human nutrition, immune response, gut microbiome, and cognition in an isolated and confined mission environment Open
View article: Longitudinal metabolomic profiles reveal sex-specific adjustments to long-duration spaceflight and return to Earth
Longitudinal metabolomic profiles reveal sex-specific adjustments to long-duration spaceflight and return to Earth Open
View article: Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight
Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight Open
View article: Longitudinal Metabolomic Profiles Reveal Sex-specific Adjustments to Long-duration Spaceflight and Return to Earth
Longitudinal Metabolomic Profiles Reveal Sex-specific Adjustments to Long-duration Spaceflight and Return to Earth Open
Spaceflight entails a variety of environmental and psychological stressors that may have long-term physiological and genomic consequences. Metabolomics, an approach that investigates the terminal metabolites of complex physiological altera…