Sara Rushwan
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View article: The economic and health impact of substandard uterotonic use for prevention of postpartum hemorrhage in three Sub-Saharan African countries: a comparative analysis
The economic and health impact of substandard uterotonic use for prevention of postpartum hemorrhage in three Sub-Saharan African countries: a comparative analysis Open
Background Uterotonics are essential in reducing the risk of postpartum haemorrhage (PPH) and saving mothers’ lives. However, numerous quality-testing studies have found that uterotonics in many low- and middle-income countries are substan…
View article: Modeling the economic and health impact of substandard uterotonics in Senegal
Modeling the economic and health impact of substandard uterotonics in Senegal Open
Background Maternal mortality due to postpartum hemorrhage (PPH) remains a global concern especially in low- and lower-middle income countries. PPH is preventable with quality-assured uterotonics. However, substandard uterotonics pose a si…
View article: Factors Influencing Pregnant Women's Participation in Randomised Clinical Trials in India: A Qualitative Study
Factors Influencing Pregnant Women's Participation in Randomised Clinical Trials in India: A Qualitative Study Open
Objective To explore factors affecting participation of pregnant women in randomised clinical trials in Belagavi, Karnataka, India. Design A qualitative study using semi‐structured in‐depth interviews and focus group discussions as data co…
View article: Modelling the economic impact of substandard uterotonics on postpartum haemorrhage in Nigeria: safeguarding medicine quality can reduce costs and contribute towards universal health coverage
Modelling the economic impact of substandard uterotonics on postpartum haemorrhage in Nigeria: safeguarding medicine quality can reduce costs and contribute towards universal health coverage Open
Introduction Little evidence exists on the economic threat that substandard uterotonics pose to postpartum haemorrhage (PPH), maternal mortality, and national health systems. For clinical emergencies such as PPH, the quality of the uteroto…
View article: Research agenda for ending preventable maternal deaths from postpartum haemorrhage: a WHO research prioritisation exercise
Research agenda for ending preventable maternal deaths from postpartum haemorrhage: a WHO research prioritisation exercise Open
Introduction Postpartum haemorrhage (PPH) remains the leading cause of maternal death. Yet there is a lack of clarity around what research is needed to determine what works and how best to deliver proven PPH interventions. This article des…
View article: Eliminating gender bias in biomedical research requires fair inclusion of pregnant women and gender diverse people
Eliminating gender bias in biomedical research requires fair inclusion of pregnant women and gender diverse people Open
Systematic under-representation of pregnant women and gender diverse pregnant people in clinical research has prevented them from benefitting fairly from biomedical advances. The resulting lack of pharmacological safety and efficacy data l…
View article: Integrating Heat-Stable Carbetocin and Tranexamic Acid for Prevention and Management of Postpartum Hemorrhage in Sub-Saharan Africa: A Five-Country Pilot Implementation Study
Integrating Heat-Stable Carbetocin and Tranexamic Acid for Prevention and Management of Postpartum Hemorrhage in Sub-Saharan Africa: A Five-Country Pilot Implementation Study Open
Background and Objective Globally, postpartum hemorrhage (PPH) remains the most common direct cause of maternal mortality. This study evaluated the feasibility and acceptability of introducing heat-stable carbetocin (HSC) for PPH preventio…
View article: Feasibility, Acceptability, and Appropriate Use of Novel and Lesser-Used Medicines for Prevention and Treatment of Postpartum Hemorrhage: Evidence from Implementation Research
Feasibility, Acceptability, and Appropriate Use of Novel and Lesser-Used Medicines for Prevention and Treatment of Postpartum Hemorrhage: Evidence from Implementation Research Open
Maternal mortality remains one of the primary global health challenges of the 21st century, despite major medical advances in the field. Although solutions are available, inequities determine where mothers die, with the majority of materna…
View article: A Tale of Two Medicines: The Need for Ownership, End-to-End Planning and Execution for Development and Introduction of Maternal Health Medicines.
A Tale of Two Medicines: The Need for Ownership, End-to-End Planning and Execution for Development and Introduction of Maternal Health Medicines. Open
Postpartum hemorrhage (PPH) persists as the leading direct cause of maternal mortality in low- and middle-income countries (LMICs) and is a major global health challenge. Following favorable evidence from pivotal efficacy clinical trials, …
View article: Modeling the economic burden of postpartum hemorrhage due to substandard uterotonics in Ghana
Modeling the economic burden of postpartum hemorrhage due to substandard uterotonics in Ghana Open
Uterotonics are essential in preventing postpartum hemorrhage (PPH), the leading direct cause of maternal death worldwide. However, uterotonics are often substandard in low- and middle-income countries, contributing to poor maternal health…
View article: Modeling the economic burden of postpartum hemorrhage due to substandard uterotonics in Ghana
Modeling the economic burden of postpartum hemorrhage due to substandard uterotonics in Ghana Open
Uterotonics are essential in preventing postpartum hemorrhage (PPH), the leading direct cause of maternal death worldwide. However, uterotonics are often substandard in low- and middle-income countries, contributing to poor maternal health…
View article: Factors influencing the participation of pregnant and lactating women in clinical trials: A mixed-methods systematic review
Factors influencing the participation of pregnant and lactating women in clinical trials: A mixed-methods systematic review Open
Background Poor representation of pregnant and lactating women and people in clinical trials has marginalised their health concerns and denied the maternal–fetal/infant dyad benefits of innovation in therapeutic research and development. T…
View article: Analysis of a maternal health medicines pipeline database 2000–2021: New candidates for the prevention and treatment of fetal growth restriction
Analysis of a maternal health medicines pipeline database 2000–2021: New candidates for the prevention and treatment of fetal growth restriction Open
Objective The Accelerating Innovation for Mothers project established a new database of candidate medicines under development between 2000 and 2021 for five pregnancy‐related conditions, including fetal growth restriction. The objective wa…
View article: Challenges in updating national guidelines and essential medicines lists in <scp>Sub‐Saharan</scp> African countries to include <scp>WHO</scp>‐recommended postpartum hemorrhage medicines
Challenges in updating national guidelines and essential medicines lists in <span>Sub‐Saharan</span> African countries to include <span>WHO</span>‐recommended postpartum hemorrhage medicines Open
Despite the 2017 WHO recommendations on tranexamic acid (TXA) for the treatment of postpartum hemorrhage (PPH), the 2018 uterotonic recommendations (which included heat‐stable carbetocin (HSC) for the prevention of PPH) and their inclusion…
View article: Quality of oxytocin and tranexamic acid for the prevention and treatment of postpartum hemorrhage in Kenya, Nigeria, South Africa, and Tanzania
Quality of oxytocin and tranexamic acid for the prevention and treatment of postpartum hemorrhage in Kenya, Nigeria, South Africa, and Tanzania Open
Objective To check the quality of oxytocin and tranexamic acid—two recommended products for prevention and treatment of postpartum hemorrhage (PPH)—used in facilities taking part in an implementation research project to improve PPH diagnos…
View article: Innovations in the prevention and treatment of postpartum hemorrhage: Analysis of a novel medicines development pipeline database
Innovations in the prevention and treatment of postpartum hemorrhage: Analysis of a novel medicines development pipeline database Open
Background A significant barrier to improving prevention and treatment of postpartum hemorrhage (PPH) is a lack of innovative medicines that meet the needs of women and providers, particularly those in low‐and middle‐income countries (LMIC…