Shahin Sayed
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View article: 1111 Single-cell-driven design of logic-gated CAR circuits for enhanced solid tumor immunotherapy
1111 Single-cell-driven design of logic-gated CAR circuits for enhanced solid tumor immunotherapy Open
View article: Gut Microbiota in Different Stages and Subtypes of Colorectal Cancer in Nairobi, Kenya
Gut Microbiota in Different Stages and Subtypes of Colorectal Cancer in Nairobi, Kenya Open
Background: Sub-Saharan African colorectal cancer (CRC) incidence is rising with delayed diagnosis being common since the population does not have access to many screening programs. Alterations in gut microbiota have been associated with C…
View article: Induction of an early IFN-γ cellular response and high plasma levels of SDF-1α are inversely associated with COVID-19 severity and residence in rural areas in Kenyan patients
Induction of an early IFN-γ cellular response and high plasma levels of SDF-1α are inversely associated with COVID-19 severity and residence in rural areas in Kenyan patients Open
Introduction COVID-19 was less severe in Sub-Saharan Africa (SSA) compared with Europe and North America. It is unclear whether these differences could be explained immunologically. Here we determined levels of ex vivo SARS-CoV-2 peptide-s…
View article: The role of various radiotherapy techniques in prostate cancer treatment (review article)
The role of various radiotherapy techniques in prostate cancer treatment (review article) Open
View article: Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy
Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy Open
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies. However, its application in solid tumors remains limited because single targets are unlikely to suffice due to tumor antigen het…
View article: Molecular profile of non-small cell lung cancer in a predominantly Black African population in Kenya: A single institution review
Molecular profile of non-small cell lung cancer in a predominantly Black African population in Kenya: A single institution review Open
In our setting, EGFR testing was the most common molecular test done for lung cancer with a positive rate like that reported in Asian communities. Further studies are needed in a larger population to define further the molecular profile of…
View article: Incorporating AI, <i>in silico</i> , and CRISPR technologies to uncover the potential of repurposed drugs in cancer therapy
Incorporating AI, <i>in silico</i> , and CRISPR technologies to uncover the potential of repurposed drugs in cancer therapy Open
This figure shows how the integration of AI, in silico methods, and CRISPR technology revolutionizes cancer drug repurposing, enabling efficient discovery and validation of repurposed drugs, accelerating the development of novel cancer the…
View article: Induction of an early IFN-γ cellular response and high plasma levels of SDF-1α are inversely associated with COVID-19 severity and residence in rural areas in Kenyan patients
Induction of an early IFN-γ cellular response and high plasma levels of SDF-1α are inversely associated with COVID-19 severity and residence in rural areas in Kenyan patients Open
Introduction COVID-19 was less severe in Sub-Saharan Africa (SSA) compared with Europe and North America. It is unclear whether these differences could be explained immunologically. Here we determined the levels of ex vivo SARS-CoV-2 pepti…
View article: Whole exome-seq and RNA-seq data reveal unique neoantigen profiles in Kenyan breast cancer patients
Whole exome-seq and RNA-seq data reveal unique neoantigen profiles in Kenyan breast cancer patients Open
Background The immune response against tumors relies on distinguishing between self and non-self, the basis of cancer immunotherapy. Neoantigens from somatic mutations are central to many immunotherapeutic strategies and understanding thei…
View article: Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study
Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study Open
Background Given the low levels of coronavirus disease 2019 (COVID-19) vaccine coverage in sub-Saharan Africa (sSA), despite high levels of natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exposures, strategies for exte…
View article: Whole exome-seq and RNA-seq data reveal unique neoantigen profiles in Kenyan breast cancer patients
Whole exome-seq and RNA-seq data reveal unique neoantigen profiles in Kenyan breast cancer patients Open
Background The immune response against tumors relies on distinguishing between self and non-self, the basis of cancer immunotherapy. Neoantigens from somatic mutations are central to many immunotherapeutic strategies and understanding thei…
View article: The Association between the JAK-STAT Pathway and Hypertension among Kenyan Women Diagnosed with Breast Cancer
The Association between the JAK-STAT Pathway and Hypertension among Kenyan Women Diagnosed with Breast Cancer Open
Background Breast cancer is the most common malignant tumor in women worldwide, and disproportionately affects Sub-Saharan Africa compared to high income countries. The global disease burden is growing, with Sub-Saharan Africa reporting ma…
View article: Development of an online teaching platform to improve access to postgraduate pathology training in sub-Saharan Africa
Development of an online teaching platform to improve access to postgraduate pathology training in sub-Saharan Africa Open
Background Resource barriers to the provision of accessible training in cancer diagnosis in lower- and middle-income countries (LMICs) limit the potential of African health systems. Long-term provision via teaching visits from senior patho…
View article: Post-vaccination SARS-CoV-2 IgG spike antibody responses among clinical and non-clinical healthcare workers at a tertiary facility in Kenya
Post-vaccination SARS-CoV-2 IgG spike antibody responses among clinical and non-clinical healthcare workers at a tertiary facility in Kenya Open
Introduction Following the coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, vaccination became the main strategy against disease severity and even death. Healthcare worker…
View article: FIGURE 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
FIGURE 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Mutational profiles in breast tumors according to ancestral background of the patients. A, Circos admixture plot showing proportions of West African, European, and Asian ancestry (outer circle) in self-identified AA (blue, inner cir…
View article: Supplementary Table 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Table 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Differentially expressed genes and pathway enrichment analysis comparing the 3 patient groups, EA, AA and Kenyan.
View article: Supplementary Table 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Table 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Patient characteristics for Kenyan Cohort
View article: FIGURE 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
FIGURE 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Pattern of somatic mutations among AA and EA patients. A, Genes enriched with somatic mutations showing robust frequency differences or exclusivity in AA and EA patients with breast cancer. FOXA1 mutation frequency is shown a…
View article: Supplementary Figure 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 2 shows the distribution of immune cell types in breast tumors.
View article: Data from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Data from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Women of African descent have the highest breast cancer mortality in the United States and are more likely than women from other population groups to develop an aggressive disease. It remains uncertain to what extent breast cancer in Afric…
View article: Supplementary Table 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Table 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Patient characteristics for NCI-Maryland cohort.
View article: Supplementary Figure 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 2 shows the distribution of immune cell types in breast tumors.
View article: Supplementary Figure 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 1 shows the effect of acquired FOXA1 somatic mutations on breast cancer survival.
View article: Supplementary Figure 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 3 shows mutational signatures in breast tumors and their association with somatic mutations in driver genes and immune cell signatures.
View article: FIGURE 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
FIGURE 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Neighborhood deprivation and its association with mutational signatures. A, Relationship of the NDI with race/ethnicity, household income, BMI, age, disease stage, tumor ER status, and tumor TP53 and TBX3 mutational st…
View article: Supplementary Figure 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 4 shows neighborhood deprivation as a determinant of breast cancer survival in the NCI-Maryland cohort.
View article: Supplementary Figure 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 4 shows neighborhood deprivation as a determinant of breast cancer survival in the NCI-Maryland cohort.
View article: Supplementary Figure 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 3 shows mutational signatures in breast tumors and their association with somatic mutations in driver genes and immune cell signatures.
View article: FIGURE 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
FIGURE 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Neighborhood deprivation and its association with mutational signatures. A, Relationship of the NDI with race/ethnicity, household income, BMI, age, disease stage, tumor ER status, and tumor TP53 and TBX3 mutational st…
View article: Supplementary Table 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Table 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Patient characteristics for NCI-Maryland cohort.