Sergio Fazio
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View article: Insulin Resistance/Hyperinsulinemia Should Be Considered in the Prevention and Treatment of Essential Hypertension
Insulin Resistance/Hyperinsulinemia Should Be Considered in the Prevention and Treatment of Essential Hypertension Open
Essential (primary) hypertension is defined as such because it does not have an identifiable cause, which is different from secondary hypertension which generally recognizes renal, endocrine, or blood vessel disorders. It is a recognized i…
View article: Correction: Insulin resistance/hyperinsulinemia: an important cardiovascular risk factor that has long been underestimated
Correction: Insulin resistance/hyperinsulinemia: an important cardiovascular risk factor that has long been underestimated Open
[This corrects the article DOI: 10.3389/fcvm.2024.1380506.].
View article: Feature Reviews in Cardiovascular Diseases
Feature Reviews in Cardiovascular Diseases Open
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, with a growing impact on healthcare systems [...]
View article: Aging of the vascular system: proposal of preventive intervention with known natural substances
Aging of the vascular system: proposal of preventive intervention with known natural substances Open
Our cells and, therefore, our organism, need energy to function at their best, which is mainly produced by mitochondria. These intracellular organelles generate energy from food macromolecules across the Krebs cycle by oxidative phosphoryl…
View article: The link between insulin resistance, hyperinsulinemia and increased mortality risk
The link between insulin resistance, hyperinsulinemia and increased mortality risk Open
The analysis of the literature clearly shows that a chronic increase in circulating insulin levels associated with insulin resistance (IR) causes great damage to the body over time. In fact, insulininsulin levels are related to the develop…
View article: Abstracts of the 3rd International Electronic Conference on Biomedicines
Abstracts of the 3rd International Electronic Conference on Biomedicines Open
The 3rd International Electronic Conference on Biomedicines (ECB 2025) was an online event held from 12 to 15 May 2025, by the journal Biomedicines MDPI. The goal of this conference was to enable scientists to present their latest research…
View article: Acceptability and satisfaction of a newly developed financial preparedness program for caregivers of older adults with a chronic illness
Acceptability and satisfaction of a newly developed financial preparedness program for caregivers of older adults with a chronic illness Open
Background and Objectives To address a gap in caregiver programming focused on financial literacy and preparedness, Managing Money: A Caregiver’s Guide to Finances, a 1-hour online program, was evaluated to determine program acceptability …
View article: Apolipoprotein C3 and risk of cardiovascular events and death in patients on optimized statin treatment after recent acute coronary syndrome
Apolipoprotein C3 and risk of cardiovascular events and death in patients on optimized statin treatment after recent acute coronary syndrome Open
Aims Apolipoprotein (Apo) C3 has been associated with incident coronary heart disease and major adverse cardiovascular events (MACE). Whether ApoC3 levels predict risk in patients with acute coronary syndrome (ACS) on optimized statin trea…
View article: A Descriptive Review on the Association of Insulin Resistance/Hyperinsulinemia with Increased Mortality Risk
A Descriptive Review on the Association of Insulin Resistance/Hyperinsulinemia with Increased Mortality Risk Open
The analysis of the literature clearly shows that chronic increase of circulating insulin levels associated with insulin resistance (IR) cause, over time, great damage to our body. In fact, they are related to the development of type 2 dia…
View article: Insulin Resistance with Associated Hyperinsulinemia as a Cause of the Development and Worsening of Heart Failure
Insulin Resistance with Associated Hyperinsulinemia as a Cause of the Development and Worsening of Heart Failure Open
Despite the considerable progress that has been made with regard to the prevention and treatment of cardiovascular diseases, heart failure (HF) remains a particularly important cause of recurring hospitalizations, with relevant social and …
View article: Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study
Autoantibodies Targeting G-Protein-Coupled Receptors and RAS-Related Molecules in Post-Acute COVID Vaccination Syndrome: A Retrospective Case Series Study Open
Background/Objectives: While post-acute COVID-19 syndrome is well known and extensively studied, the post-acute COVID vaccination syndrome (PACVS) is a more recent nosological entity that is poorly defined at the immunopathological level, …
View article: THE EMPOWERED CAREGIVER: A SCALABLE AND PRAGMATIC EVIDENCE-BASED PROGRAM FOR DEMENTIA CAREGIVERS
THE EMPOWERED CAREGIVER: A SCALABLE AND PRAGMATIC EVIDENCE-BASED PROGRAM FOR DEMENTIA CAREGIVERS Open
Informal caregivers provide the bulk of care to older adults with dementia. Few studies have evaluated pragmatic and scalable on-line educational programs for caregivers. An RCT (N=247) was used to evaluate a new program, Empowered Caregiv…
View article: THE NEED FOR PRAGMATIC PROGRAMMING FOR CAREGIVERS: EVIDENCE FROM MANAGING MONEY: A CAREGIVER’S GUIDE TO FINANCES
THE NEED FOR PRAGMATIC PROGRAMMING FOR CAREGIVERS: EVIDENCE FROM MANAGING MONEY: A CAREGIVER’S GUIDE TO FINANCES Open
Several key issues remain in the caregiving intervention literature. Programs must seamlessly transition and scale into existing settings with plans for long-term implementation. Programs should be accessible, digestible, and efficient for…
View article: THREE DECADES OF PERSON-CENTERED DEMENTIA CARE: LESSONS LEARNED AND FUTURE CONSIDERATIONS
THREE DECADES OF PERSON-CENTERED DEMENTIA CARE: LESSONS LEARNED AND FUTURE CONSIDERATIONS Open
Dr. Fazio has been involved in person-centered dementia care for more than three decades. In this presentation, Dr. Fazio will review the origins of person-centered care and ongoing research, as well as share highlights of his personal res…
View article: PERSPECTIVES ON PERSON-CENTEREDNESS ACROSS HEALTH CARE SETTINGS
PERSPECTIVES ON PERSON-CENTEREDNESS ACROSS HEALTH CARE SETTINGS Open
Systems perspectives generally identify three levels of action: the interpersonal (micro) level, the institutional (meso) level, and the broader societal (macro) level. Person-centeredness is generally viewed at the interpersonal level, bu…
View article: Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer
Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer Open
Despite all the progress made by science in the prevention and treatment of cardiovascular diseases and cancers, these are still the main reasons for hospitalizations and death in the Western world. Among the possible causes of this situat…
View article: Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer
Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer Open
This review aims to show, by an analysis of the literature on the topic, that hyperinsulinemia associated with insulin resistance is a multiple risk factor for type 2 diabetes, cardiovascular diseases, cellular senescence and cancer, and n…
View article: Insulin Resistance, a Risk Factor for Alzheimer’s Disease: Pathological Mechanisms and a New Proposal for a Preventive Therapeutic Approach
Insulin Resistance, a Risk Factor for Alzheimer’s Disease: Pathological Mechanisms and a New Proposal for a Preventive Therapeutic Approach Open
Peripheral insulin resistance (IR) is a well-documented, independent risk factor for the development of type 2 diabetes, cardiovascular disease, cancer and cellular senescence. Recently, the brain has also been identified as an insulin-res…
View article: Low prevalence of testing for apolipoprotein B and lipoprotein (a) in the real world
Low prevalence of testing for apolipoprotein B and lipoprotein (a) in the real world Open
These data should be considered by guideline-issuing agencies and organizations to develop education campaigns encouraging more frequent use of tests beyond the standard lipid panel.
View article: Insulin Resistance/Hyperinsulinemia as an Independent Risk Factor That Has Been Overlooked for Too Long
Insulin Resistance/Hyperinsulinemia as an Independent Risk Factor That Has Been Overlooked for Too Long Open
Unfortunately, cardiovascular diseases and cancers are still the leading causes of death in developed and developing countries despite the considerable progress made in the prevention and treatment of diseases. Maybe we missed something? I…
View article: Insulin Resistance/Hyperinsulinemia, Neglected Risk Factor for the Development and Worsening of Heart Failure with Preserved Ejection Fraction
Insulin Resistance/Hyperinsulinemia, Neglected Risk Factor for the Development and Worsening of Heart Failure with Preserved Ejection Fraction Open
Heart failure (HF) has become a subject of continuous interest since it was declared a new pandemic in 1997 because of the exponential increase in hospitalizations for HF in the latest years. HF is the final state to which all heart diseas…
View article: Insulin Resistance/Hyperinsulinemia as an Independent Risk Factor for the Development and Worsening of HFpEF
Insulin Resistance/Hyperinsulinemia as an Independent Risk Factor for the Development and Worsening of HFpEF Open
Insulin resistance/hyperinsulinemia as an independent risk factor for the development and worsening of HFpEF. Serafino Fazio MD¹, Valentina Mercurio MD, PhD2, Valeria Fazio MD3, Antonio Ruvolo MD⁴, Flora Affuso MD, PhD⁵. Authors’ Affiliati…
View article: Insulin resistance/hyperinsulinemia: an important cardiovascular risk factor that has long been underestimated
Insulin resistance/hyperinsulinemia: an important cardiovascular risk factor that has long been underestimated Open
Cardiovascular mortality is still excessively high, despite the considerable progress made in the prevention and treatment of cardiovascular diseases. Although many cardiovascular risk factors (such as arterial hypertension, hypercholester…
View article: Review of: "Retinal Vasculitis Following COVID-19 Infection: A Systematic Review"
Review of: "Retinal Vasculitis Following COVID-19 Infection: A Systematic Review" Open
Potential competing interests: No potential competing interests to declare.The manuscript aims to be a review of vasculitic complications localized to the eyes during SARS-CoV-2 infection.The review is a little lacking in data and, in the …
View article: RECONSTRUCTING PERSON-CENTEREDNESS FROM A SYSTEMS PERSPECTIVE: IMPLICATIONS FOR THE CARE OF OLDER ADULTS
RECONSTRUCTING PERSON-CENTEREDNESS FROM A SYSTEMS PERSPECTIVE: IMPLICATIONS FOR THE CARE OF OLDER ADULTS Open
Person-centeredness has become a common, almost hackneyed phrase in the context of care for older adults, despite a lack of consensus regarding its definition, measurement, and application. As part of a series of studies aimed at better un…
View article: The Negative Impact of Insulin Resistance/Hyperinsulinemia on Chronic Heart Failure and the Potential Benefits of Its Screening and Treatment
The Negative Impact of Insulin Resistance/Hyperinsulinemia on Chronic Heart Failure and the Potential Benefits of Its Screening and Treatment Open
This opinion article highlights the potential alterations caused by insulin resistance and hyperinsulinemia on the cardiovascular system and their negative impact on heart failure (HF), and describes the potential benefits of an early scre…