Sara Söderqvist
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View article: An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer Open
Pancreatic cancer is an aggressive disease with a dense fibrotic stroma and is often accompanied by chronic inflammation. Peritumoral inflammation is typically viewed as a reaction to nearby tumor growth. Here, we report that the inflamed …
View article: A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype
A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor type characterized by a particularly extensive stroma. While different types of cancer-associated fibroblasts (CAFs) in this desmoplastic stroma have been described, area…
View article: An idiosyncratic, zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
An idiosyncratic, zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver Open
Colorectal cancer liver metastases (CRLM) grow in two major patterns defined by the histomorphology of the invasion front, replacement or desmoplastic . The desmoplastic pattern, in which a stromal rim separates tumor cells and liver paren…