Sara Taleb
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View article: Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity
Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity Open
Introduction. Pre-existing immunity to human coronaviruses (HCoVs) may shape the immune response in COVID-19 patients. Increasing evidence suggests that immune cross-reactivity between SARS-CoV-2 and other coronaviruses may determine clini…
View article: SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines
SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines Open
Neutralizing antibodies (NAbs) are elicited after infection and vaccination and have been well studied. However, their antibody‐dependent cellular cytotoxicity (ADCC) functionality is still poorly characterized. Here, we investigated ADCC …
View article: Evaluation of psychological distress, burnout and structural empowerment status of healthcare workers during the outbreak of coronavirus disease (COVID-19): a cross-sectional questionnaire-based study
Evaluation of psychological distress, burnout and structural empowerment status of healthcare workers during the outbreak of coronavirus disease (COVID-19): a cross-sectional questionnaire-based study Open
View article: Olink and NULISAseq Proteomic Technologies Applied to a COVID-19-Induced Acute Respiratory Distress Syndrome (ARDS) Case-Control Study Revealed High Similarity and Complementarity and Shed Light on the Cytokine Storm
Olink and NULISAseq Proteomic Technologies Applied to a COVID-19-Induced Acute Respiratory Distress Syndrome (ARDS) Case-Control Study Revealed High Similarity and Complementarity and Shed Light on the Cytokine Storm Open
View article: Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization Open
Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of ag…
View article: A CRISPR-based approach using dead Cas9-sgRNA to detect SARS-CoV-2
A CRISPR-based approach using dead Cas9-sgRNA to detect SARS-CoV-2 Open
Rapid, highly specific, and robust diagnostic kits to detect viruses and pathogens are needed to control disease spread and transmission globally. Of the many different methods proposed to diagnose COVID-19 infection, CRISPR-based detectio…
View article: Additional file 1 of Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Additional file 1 of Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization Open
Additional file 1. Correlation of chronological age with DNA methylation age using Horvath, Hannum, SkinandBlood, PhenoAge, and GrimAge clocks and the DNA methylation-based telomere length (TL) estimator.
View article: High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines Open
Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via high–temporal resolution…
View article: High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection
High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection Open
Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here we investigated responses to COVID-19 mRNA vaccination via ultra-low-volume sampling and high-temporal-resoluti…
View article: Predictive Biomarkers of Intensive Care Unit and Mechanical Ventilation Duration in Critically-Ill Coronavirus Disease 2019 Patients
Predictive Biomarkers of Intensive Care Unit and Mechanical Ventilation Duration in Critically-Ill Coronavirus Disease 2019 Patients Open
Introduction: Detection of early metabolic changes in critically-ill coronavirus disease 2019 (COVID-19) patients under invasive mechanical ventilation (IMV) at the intensive care unit (ICU) could predict recovery patterns and help in dise…
View article: Development of an in-house COVID-19 serology ELISA Test
Development of an in-house COVID-19 serology ELISA Test Open
Background: COVID-19 pandemic created an unprecedented demand for reagents and diagnostic tools to confirm COVID-19 cases. Thus, the development of a robust in-house diagnostic test is considered of high importance. Within a few days after…
View article: Level of maternal respiratory syncytial virus (RSV) F antibodies in hospitalized children and correlates of protection
Level of maternal respiratory syncytial virus (RSV) F antibodies in hospitalized children and correlates of protection Open
View article: Detection of antinuclear antibodies targeting intracellular signal transduction, metabolism, apoptotic processes and cell death in critical COVID-19 patients
Detection of antinuclear antibodies targeting intracellular signal transduction, metabolism, apoptotic processes and cell death in critical COVID-19 patients Open
Background The heterogeneity of COVID-19 lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) has been shown to be the leading cause of mortality in COVID-19 patients, chara…
View article: In silico virtual screening of lead compounds for major antigenic sites in respiratory syncytial virus fusion protein
In silico virtual screening of lead compounds for major antigenic sites in respiratory syncytial virus fusion protein Open
View article: Nutrition Literacy among Adolescents and Its Association with Eating Habits and BMI in Tripoli, Lebanon
Nutrition Literacy among Adolescents and Its Association with Eating Habits and BMI in Tripoli, Lebanon Open
(1) Background: Adolescence is a period of increased autonomy and independent decision making; it determines health behaviors that can persist into the future. Individual factors like food choices and unhealthy lifestyle have an essential …
View article: Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar
Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar Open
Human parvovirus (B19V) is the causative agent of erythema infectiosum in children and is linked to a wide range of clinical manifestations. Studies related to B19V prevalence in the Middle East and North Africa (MENA) region and other par…
View article: Detection of autoimmune antibodies in severe but not in moderate or asymptomatic COVID-19 patients
Detection of autoimmune antibodies in severe but not in moderate or asymptomatic COVID-19 patients Open
The heterogeneity of COVID-19 lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) has been shown to be the leading cause of mortality in COVID-19 patients, characterized by…
View article: Evaluation of Antibody Response in Symptomatic and Asymptomatic COVID-19 Patients and Diagnostic Assessment of New IgM/IgG ELISA Kits
Evaluation of Antibody Response in Symptomatic and Asymptomatic COVID-19 Patients and Diagnostic Assessment of New IgM/IgG ELISA Kits Open
This study aims to study the immune response and evaluate the performances of four new IgM and five IgG enzyme-linked immunosorbent assay (ELISA) kits for detecting anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodi…
View article: Predictive biomarkers of ICU and mechanical ventilation duration in critically-ill COVID19 patients
Predictive biomarkers of ICU and mechanical ventilation duration in critically-ill COVID19 patients Open
Background: Detection of early metabolic changes in critically-ill COVID-19 patients under invasive mechanical ventilation (IMV) at the intensive care unit (ICU) could predict recovery patterns and help in disease management. Methods: Targ…
View article: Metabolomics of critically-ill COVID19 patients
Metabolomics of critically-ill COVID19 patients Open
Raw metabolomics data for critically ill COVID-19 patients at ICU
View article: Does Hypofractionated Radiotherapy Regimens Increase the Vulnerability to SARS- COV-2 by Influencing ACE-2 Activity?
Does Hypofractionated Radiotherapy Regimens Increase the Vulnerability to SARS- COV-2 by Influencing ACE-2 Activity? Open
In the context of the novel Coronavirus pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the management of patients with cancer constitutes a real challenge. These patients are more likely to be immunocompromis…
View article: Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies
Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies Open
View article: Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update
Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update Open
Hepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause acute and chronic hepatitis. According to the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), 257 million pe…
View article: Enhancing NY-ESO-1 antigen expression in lung cancer cells through gene hypomethylation using 5-Aza-2′-deoxycytidine
Enhancing NY-ESO-1 antigen expression in lung cancer cells through gene hypomethylation using 5-Aza-2′-deoxycytidine Open
Background: NY-ESO-1 is a highly immunogenic cancer-testis antigens and it is a potential candidate for immunotherapy. Cellular expression of NY-ESO-1 gene is heterogeneous depending on the demethylation status of its promoter. Exposure to…
View article: Prevalence and molecular profiling of Epstein Barr virus (EBV) among healthy blood donors from different nationalities in Qatar
Prevalence and molecular profiling of Epstein Barr virus (EBV) among healthy blood donors from different nationalities in Qatar Open
As a first study to evaluate EBV infection in highly diverse population in Qatar, where expatriates represent more than 85% of the population, our results indicated high seroprevalence and viremia rate of EBV in different nationalities, wi…
View article: Concomitant occurrence of primary hyperparathyroidism ( <scp>PHPT</scp> ) due to mediastinal parathyroid adenoma and sublingual thyroid gland: the role of parathyroid technetium‐99m‐ <scp>MIBI</scp> scintigraphy
Concomitant occurrence of primary hyperparathyroidism ( <span>PHPT</span> ) due to mediastinal parathyroid adenoma and sublingual thyroid gland: the role of parathyroid technetium‐99m‐ <span>MIBI</span> scintigraphy Open
Key Clinical Message The concomitant appearance of a sublingual thyroid and primary hyperparathyroidism due to parathyroid mediastinal adenoma is not common. This co‐occurrence can lead to a misdiagnosis by morphological imaging methods al…
View article: Seroprevalence of hepatitis E virus among blood donors in Qatar (2013‐2016)
Seroprevalence of hepatitis E virus among blood donors in Qatar (2013‐2016) Open
BACKGROUND Hepatitis E virus (HEV) is an RNA virus transmitted mainly through zoonotic transmission or fecal–oral route. More than 80% of Qatar's population are expatriates, including many coming from hyperendemic countries; thus, it is im…
View article: Is it the time for Hepatitis E virus (HEV) Testing for Blood Donors in Qatar?
Is it the time for Hepatitis E virus (HEV) Testing for Blood Donors in Qatar? Open
Background: HEV is the etiologic agent of acute hepatitis E. Although HEV usually causes a self-limiting infection, the disease may develop into a chronic or fulminant form of Hepatitis. Sporadic HEV infections spread in several developed …
View article: Poorly differentiated thyroid carcinoma: a retrospective clinicopathological study
Poorly differentiated thyroid carcinoma: a retrospective clinicopathological study Open
Poorly differentiated thyroid carcinoma (PDTC) is an independent thyroid cancer histotype. In spite of its scarcity, it represents the main cause of death from non-anaplastic follicular cell-derived thyroid cancer. However, given the newne…