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View article: Tolerogenic nanoparticles suppress central nervous system inflammation
Tolerogenic nanoparticles suppress central nervous system inflammation Open
Significance Current treatments for autoimmune diseases rely on nonspecific immunosuppression, risking important complications and limiting the long-term use of these approaches for the treatment of chronic human autoimmunity. Thus, there …
View article: Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes
Islet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes Open
Extracellular ATP (eATP) activates T cells by engaging the P2X7R receptor. We identified two loss-of-function P2X7R mutations that are protective against type 1 diabetes (T1D) and thus hypothesized that eATP/P2X7R signaling may represent a…
View article: P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes
P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes Open
Purinergic receptor-7 (P2X7R) signaling controls Th17 and Th1 generation/differentiation, while NOD-like receptor P3 (NLRP3) acts as a Th2 transcriptional factor. Here, we demonstrated the existence of a P2X7R/NLRP3 pathway in T cells that…
View article: PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes
PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes Open
Restoration of a PD-L1 defect in HSPCs reverses diabetes in NOD mice and thus may represent a potential cure for T1D.
View article: Metabolomic Profiling in Individuals with a Failing Kidney Allograft
Metabolomic Profiling in Individuals with a Failing Kidney Allograft Open
We report an association between renal function and altered metabolomic profile in renal transplant individuals with different degrees of kidney graft function.
View article: ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration
ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration Open
Age is a major risk factor in age-related macular degeneration (AMD), but the underlying cause is unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 characteristics in eyes of aged mice, revealing immune changes in ag…