Explanipedia

Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity Open

Baiye Ruan, Yuanting Chen, Sara Trimidal, Manash Chakraborty, Aashka Shah , et al. · 2025

Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity Open

Baiye Ruan, Yuanting Chen, Sara Trimidal, Imhoi Koo, Jingwei Cai , et al. · 2023

Steady state erythropoiesis produces new erythrocytes at a constant rate to replace senescent erythrocytes removed in the spleen and liver. Inflammation caused by infection or tissue damage skews bone marrow hematopoiesis, increasing myelo…

Nitric oxide regulates metabolism in murine stress erythroid progenitors to promote recovery during inflammatory anemia Open

Baiye Ruan, Yuanting Chen, Sara Trimidal, Imhoi Koo, Fenghua Qian , et al. · 2023

Inflammation skews bone marrow hematopoiesis increasing the production of myeloid effector cells at the expense of steady-state erythropoiesis. A compensatory stress erythropoiesis response is induced to maintain homeostasis until inflamma…

XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks Open

Ronald Benjamin, Atoshi Banerjee, Xiaogang Wu, Corey Geurink, Lindsay Buczek , et al. · 2022

Double-strand breaks (DSB) are one of the most lethal forms of DNA damage that, if left unrepaired, can lead to genomic instability, cellular transformation, and cell death. In this work, we examined how repair of transcription activator-l…

Robust Transcriptional Regulatory Response Upon Blocking NHEJ Open

Ronald Benjamin, Atoshi Banerjee, Corey Guerunk, Lindsay Buczek, Danielle Eames , et al. · 2021

Double strand breaks are one of the most lethal forms of DNA lesions that, if left unrepaired can lead to genomic instability, cellular transformation, and cell death. However, cells have two main machineries namely error prone Non homolog…

BioEssays 12/2019 Open

Sara Trimidal, Ronald Benjamin, Ji Eun Bae, Mira Han, Elizabeth Kong , et al. · 2019

Gene editing with engineered nucleases introduce double-strand breaks that are repaired by error-prone nonhomologous end-joining (NHEJ). In article number 1900126, Sara G. Trimidal et al. propose that the length and type or resulting indel…

Can Designer Indels Be Tailored by Gene Editing? Open

Sara Trimidal, Ronald Benjamin, Ji Eun Bae, Mira Han, Elizabeth Kong , et al. · 2019

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Wheth…

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