Sara Ture
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View article: Compound heterozygous <scp>RYR1</scp> ‐ <scp>RM</scp> mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival
Compound heterozygous <span>RYR1</span> ‐ <span>RM</span> mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival Open
Pathogenic variants in the type I ryanodine receptor (RYR1) result in a wide range of muscle disorders referred to as RYR1‐related myopathies (RYR1‐RM). We developed the first RYR1‐RM mouse model resulting from co‐inheritance of two differ…
View article: Long-lived lung megakaryocytes contribute to platelet recovery in thrombocytopenia models
Long-lived lung megakaryocytes contribute to platelet recovery in thrombocytopenia models Open
Lung megakaryocytes (Mks) are largely extravascular with an immune phenotype (1). Because bone marrow (BM) Mks are short lived, it has been assumed that extravascular lung Mks are constantly "seeded" from the BM. To investigate lung Mk ori…
View article: Platelet <i>Ido1</i> expression is induced during <i>Plasmodium yoelii</i> infection, altering plasma tryptophan metabolites
Platelet <i>Ido1</i> expression is induced during <i>Plasmodium yoelii</i> infection, altering plasma tryptophan metabolites Open
Platelets are immune responsive in many diseases as noted by changes in platelet messenger RNA in conditions such as sepsis, atherosclerosis, COVID-19, and many other inflammatory and infectious etiologies. The malaria causing Plasmodium p…
View article: Lung megakaryocytes are long-lived, arise from Flt3-negative bone marrow cells, and contribute to platelet recovery in thrombocytopenia
Lung megakaryocytes are long-lived, arise from Flt3-negative bone marrow cells, and contribute to platelet recovery in thrombocytopenia Open
We previously characterized lung megakaryocytes (Mks) as largely extravascular cells with an immune modulatory phenotype (Pariser et al., 2021). Because bone marrow (BM) Mks are relatively short lived, it is assumed that extravascular lung…
View article: Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function
Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function Open
BACKGROUND: While platelets have well-studied hemostatic functions, platelets are immune cells that circulate at the interface between the vascular wall and white blood cells. The physiological implications of these constant transient inte…
View article: Platelet CD47 Maintains Circulating Monocyte Immune Homeostasis
Platelet CD47 Maintains Circulating Monocyte Immune Homeostasis Open
In addition to their well-studied hemostatic functions, platelets are immune cells. Platelets circulate at the interface between the vascular wall and white blood cells, and transient platelet-leukocyte complexes are found in both healthy …
View article: Lung Megakaryocytes Arise from a Flt3 - Cell Lineage and Contribute to Recovery of Platelet Counts in Thrombocytopenic States
Lung Megakaryocytes Arise from a Flt3 - Cell Lineage and Contribute to Recovery of Platelet Counts in Thrombocytopenic States Open
Platelet-producing megakaryocytes (Mks) are present in the lung, and we have described an immune modulatory phenotype of lung Mks. It is assumed that the extravascular lung Mks are ‘seeded’ from the bone marrow (BM). To investigate lung Mk…
View article: Thrombocytopenia Independently Leads to Monocyte Immune Dysfunction
Thrombocytopenia Independently Leads to Monocyte Immune Dysfunction Open
In addition to their well-studied hemostatic functions, platelets are immune cells. Platelets circulate at the interface between the vascular wall and leukocytes, and transient platelet-leukocyte complexes are found in both healthy and dis…
View article: Monocyte-derived Dll4 is a novel contributor to persistent systemic inflammation in HIV patients
Monocyte-derived Dll4 is a novel contributor to persistent systemic inflammation in HIV patients Open
Background In people living with HIV (PLWH) on combination antiretroviral therapy (cART), persistent systemic inflammation is a driving force for the progression of comorbidities, such as cardiovascular and cerebrovascular diseases. In thi…
View article: Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice
Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice Open
Background: Thrombocytopenia is common in preterm neonates. Platelet transfusions are sometimes given to thrombocytopenic neonates with the hope of reducing the bleeding risk, however, there are little clinical data to support this practic…
View article: Long-acting PGE2 and Lisinopril Mitigate H-ARS
Long-acting PGE2 and Lisinopril Mitigate H-ARS Open
Thrombocytopenia is a major complication in hematopoietic-acute radiation syndrome (H-ARS) that increases the risk of mortality from uncontrolled hemorrhage. There is a great demand for new therapies to improve survival and mitigate bleedi…
View article: β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction
β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction Open
Rationale: Circulating monocytes can have proinflammatory or proreparative phenotypes. The endogenous signaling molecules and pathways that regulate monocyte polarization in vivo are poorly understood. We have shown that platelet-derived β…
View article: Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction
Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction Open
Objective: The platelet phenotype in certain patients and clinical contexts may differ from healthy conditions. We evaluated platelet activation through specific receptors in healthy men and women, comparing this to patients presenting wit…
View article: Lung megakaryocytes are immune modulatory cells
Lung megakaryocytes are immune modulatory cells Open
Although platelets are the cellular mediators of thrombosis, they are also immune cells. Platelets interact both directly and indirectly with immune cells, impacting their activation and differentiation, as well as all phases of the immune…
View article: Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection
Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection Open
Background Microvesicles are cell membrane–derived vesicles that have been shown to augment inflammation. Specifically, monocyte‐derived microvesicles (MDMVs), which can express the coagulation protein tissue factor, contribute to thrombus…
View article: Platelet-derived β2m regulates age related monocyte/macrophage functions
Platelet-derived β2m regulates age related monocyte/macrophage functions Open
Platelets have central roles in both immune responses and development. Stimulated platelets express leukocyte adhesion molecules and release numerous immune modulatory factors that recruit and activate leukocytes, both at the sites of acti…
View article: Platelet-derived β2M regulates monocyte inflammatory responses
Platelet-derived β2M regulates monocyte inflammatory responses Open
β-2 Microglobulin (β2M) is a molecular chaperone for the major histocompatibility class I (MHC I) complex, hemochromatosis factor protein (HFE), and the neonatal Fc receptor (FcRn), but β2M may also have less understood chaperone-independe…
View article: Acetylcholine inhibits platelet activation and regulates hemostasis
Acetylcholine inhibits platelet activation and regulates hemostasis Open
Platelets are key mediators of thrombosis. Many agonists of platelet activation are known, but there are fewer identified endogenous inhibitors of platelets, such as prostacyclin and nitric oxide (NO). Acetylcholinesterase inhibitors such …
View article: Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype
Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype Open
Objective— Reduced blood flow and tissue oxygen tension conditions result from thrombotic and vascular diseases such as myocardial infarction, stroke, and peripheral vascular disease. It is largely assumed that while platelet activation is…
View article: 2508
2508 Open
OBJECTIVES/SPECIFIC AIMS: To investigate the role of platelet factor-4 (PF4) in B cell differentiation and develop strategies to better modulate B cell differentiation in vitro and in vivo. METHODS/STUDY POPULATION: We use tissue culture a…
View article: Novel Thrombotic Function of a Human SNP in <i>STXBP5</i> Revealed by CRISPR/Cas9 Gene Editing in Mice
Novel Thrombotic Function of a Human SNP in <i>STXBP5</i> Revealed by CRISPR/Cas9 Gene Editing in Mice Open
Objective— To identify and characterize the effect of a SNP (single-nucleotide polymorphism) in the STXBP5 locus that is associated with altered thrombosis in humans. GWAS (genome-wide association studies) have identified numerous SNPs ass…
View article: Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation
Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation Open
Thrombosis-associated pathologies, such as myocardial infarction and stroke, are major causes of morbidity and mortality worldwide. Because platelets are necessary for hemostasis and thrombosis, platelet directed therapies must balance inh…
View article: Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis
Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis Open
Platelets play an essential role in hemostasis and wound healing by facilitating thrombus formation at sites of injury. Platelets also mediate inflammation and contain several pro-inflammatory molecules including cytokines and chemokines t…