Explanipedia

Profiling the genomic landscape and evolutionary history of polyploid giant cancer cells in undifferentiated pleomorphic sarcomas Open

Amy L. Bowes, Sara Waise, Tom Lesluyes, Thomas Butters, Christie English , et al. · 2025

Polyploid giant cancer cells (PGCCs), characterised by multinucleation and atypical nuclear morphology, are a common feature of undifferentiated pleomorphic sarcomas. While PGCCs may be a critical substrate for cancer evolution, their form…

An optimised computational approach for the identification of somatic structural variants in cancer Open

Sara Waise, Nana Mensah, Tom Lesluyes, Jonas Demeulemeester, Adrienne M. Flanagan , et al. · 2025

Structural variants play a critical role in tumorigenesis. At present, these events are most commonly identified using short-read whole-genome sequencing data, and a number of computational tools are available for this purpose. Consensus a…

Lingual necrosis secondary to group a streptococcal necrotising infection Open

Fatima Abeer, Madan Ethunandan, Sara Waise, Kordo Saeed · 2025

Tongue necrosis is a rare manifestation of Group A Streptococcal (GAS) infection. Only certain strains of GAS have been found to cause invasive disease in the form of necrotising skin and soft tissue infections. We present the case of an o…

Aneuploidy and complex genomic rearrangements in cancer evolution Open

Toby M. Baker, Sara Waise, Maxime Tarabichi, Peter Van Loo · 2024

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer Open

Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun , et al. · 2023

Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we use single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry (CIBERSORTx) to identify and characterise three major fibro…

A genetic model for central chondrosarcoma evolution correlates with patient outcome Open

William Cross, Iben Lyskjær, Tom Lesluyes, Steven Hargreaves, Anna‐Christina Strobl , et al. · 2022

Additional file 1 of A genetic model for central chondrosarcoma evolution correlates with patient outcome Open

William Cross, Iben Lyskjær, Tom Lesluyes, Steven Hargreaves, Anna‐Christina Strobl , et al. · 2022

Additional file 1: Supplementary Tables 1-6.

Additional file 1 of A genetic model for central chondrosarcoma evolution correlates with patient outcome Open

William Cross, Iben Lyskjær, Tom Lesluyes, Steven Hargreaves, Anna‐Christina Strobl , et al. · 2022

Additional file 1: Supplementary Tables 1-6.

A Genetic Model for Central Chondrosarcoma Evolution Correlates with Patient Outcome Open

William Cross, Iben Lyskjær, Tom Lesluyes, Steven Hargreaves, Anna‐Christina Strobl , et al. · 2021

The treatment options for central chondrosarcoma are limited, and prognoses are generally unreliable. The presence and absence of mutations in IDH1 , and IDH2 are defining events, and TERT mutations have been recently been associated with …

Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer: a systematic review and meta-analysis Open

Andrew F. Irvine, Sara Waise, Edward W. Green, Beth Stuart, Gareth J. Thomas · 2021

A non-linear optimisation method to extract summary statistics from Kaplan-Meier survival plots using the published P value Open

Andrew F. Irvine, Sara Waise, Edward W. Green, Beth Stuart · 2020

Spatially discrete signalling niches regulate fibroblast heterogeneity in human lung cancer Open

Christopher J. Hanley, Sara Waise, Robert G. Parker, Michele Antonio López, Julian Taylor , et al. · 2020

Fibroblasts are functionally heterogeneous cells, capable of promoting and suppressing tumour progression. Across cancer types, the extent and cause of this phenotypic diversity remains unknown. We used single-cell RNA sequencing and multi…

Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer : relating molecular phenotype to function Open

Sara Waise · 2020

Despite recent therapeutic advances, non-small cell lung cancer (NSCLC) remains the leading cause of cancer death worldwide. To improve survival outcomes in this disease, novel therapeutic approaches are required. Relative to other cancers…

An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing Open

Sara Waise, Rachel Parker, Matthew Rose‐Zerilli, David Layfield, Oliver Wood , et al. · 2019

Abstract 3762: Single-cell analysis of cancer-associated fibroblast heterogeneity in non-small cell lung cancer: Mapping molecular phenotypes in tumors Open

Sara Waise, Christopher J. Hanley, Rachel Parker, Christian H. Ottensmeier, Matthew Rose‐Zerilli , et al. · 2019

This work aims to characterise the heterogeneity and spatial relationships of the cancer-associated fibroblast (CAF) population in non-small cell lung cancer.Fresh human lung tissue was dissociated for sixty minutes to extract the maximum …

An Optimized Method to Isolate Human Fibroblasts from Tissue for Ex Vivo Analysis Open

Sara Waise, Rachel Parker, Matthew Rose‐Zerilli, David Layfield, Oliver Wood , et al. · 2019

Despite their involvement in many physiological and pathological processes, fibroblasts remain a poorly-characterized cell type. Analysis of primary fibroblasts while maintaining their in vivo phenotype is challenging: standard meth…

Single-cell suspensions from primary human esophagus tissue v1 Open

Annette Hayden, Robert Walker, Jack Harrington, Lucy Kimbley, Sara Waise , et al. · 2018

A protocol to dissociate fresh esophagus tissue specimens for single-cell transcriptomics.

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