Sara X. Edgecomb
YOU?
Author Swipe
View article: Ionic liquid-coated lipid nanoparticles demonstrate prolonged circulation and brain uptake via red blood cell hitchhiking
Ionic liquid-coated lipid nanoparticles demonstrate prolonged circulation and brain uptake via red blood cell hitchhiking Open
Lipid nanoparticles ( LNPs ) have transformed the delivery of nucleic acid therapeutics; however, their natural tropism favors the liver resulting in clearance by the reticuloendothelial system, with less than 1% of the injected dose reach…
View article: Cytotoxicity and cell membrane interactions of choline-based ionic liquids: Comparing amino acids, acetate, and geranate anions
Cytotoxicity and cell membrane interactions of choline-based ionic liquids: Comparing amino acids, acetate, and geranate anions Open
Ionic liquids (ILs) have found diverse applications in research and industry. Biocompatible ILs, a subset considered less toxic than traditional ILs, have expanded their applications into biomedical fields. However, there is limited unders…
View article: Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targets
Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targets Open
Ionic liquid (IL)-coated LNPs increase siRNA uptake into brain endothelial cells and motor neurons and lesser plasma proteins compared to standard LNPs.
View article: Ionic-Liquid-Modified Nanoparticles as Potential Mucus Modulators for Nasal Drug Delivery
Ionic-Liquid-Modified Nanoparticles as Potential Mucus Modulators for Nasal Drug Delivery Open
Mucosal barriers are a natural defense system for preventing the entry of foreign objects into the body; however, they pose obstacles for effective drug delivery. Coated polymer nanoparticles (NPs) have been shown to possess improved rates…
View article: Investigation of physicochemical drivers directing ionic liquid assembly on polymeric nanoparticles
Investigation of physicochemical drivers directing ionic liquid assembly on polymeric nanoparticles Open
Ionic liquids (ILs) have emerged as promising biomaterials for enhancing drug delivery by functionalizing polymeric nanoparticles (NPs). Despite the biocompatibility and biofunctionalization they confer upon the NPs, little is understood r…
View article: Selective Blood Cell Hitchhiking in Whole Blood with Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection
Selective Blood Cell Hitchhiking in Whole Blood with Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection Open
Less than 5% of intravenously-injected nanoparticles (NPs) reach destined sites in the body due to opsonization and immune-based clearance in vascular circulation. By hitchhiking in situ onto specific blood components post-injection, NPs c…