Explanipedia

Circulating Mast Cell Progenitors Are Depleted by Benralizumab in Severe Asthma Open

Michael Fricker, John Harrington, Sarah A. Hiles, Peter G. Gibson · 2025

Immune modulating effects of oral lactoferrin in healthy, older adults: a randomised controlled trial Open

Bronwyn S. Berthon, Evan J. Williams, Lily M. Williams, Kurtis F. Budden, Sarah A. Hiles , et al. · 2025

Immunoceuticals are natural products used to enhance immunity (1) . Lactoferrin (Lf) is an immunoceutical supplement which has been shown to have immunomodulatory properties (2) . The immuno-protective functions of Lf are of interest in ol…

Social determinants of mental health in asthma: an exploratory study Open

Sarah A. Hiles, Hayley Lewthwaite, Vanessa Clark, Anne E. Vertigan, Amber Smith , et al. · 2025

Introduction Asthma and mental health problems co-occur at high rates. In context of a holistic approach to health, considering the extent to which social determinants relate to mental health in people with asthma helps identify health ine…

Perceptions of sedentary behaviour in people with severe asthma: a qualitative study Open

Paola D Urroz Guerrero, Peter G. Gibson, Hayley Lewthwaite, Eleanor Majellano, Sarah A. Hiles , et al. · 2024

People with severe asthma often lead sedentary lifestyles, which adversely affects overall health and asthma-specific outcomes. To inform future sedentary behaviour- interventions, this study aimed to explore perceptions of sedentary behav…

Mepolizumab depletes inflammatory but preserves homeostatic eosinophils in severe asthma Open

Michael Fricker, John Harrington, Sarah A. Hiles, Peter G. Gibson · 2024

Background Eosinophils are key therapeutic targets in severe asthma that are suppressed by IL5 (mepolizumab) and IL5 receptor (benralizumab) blockade. The effect of IL5 pathway biologics on recently described homeostatic (hEOs) and inflamm…

Perceptions of sedentary behaviour in people with severe asthma: A qualitative study Open

Paola D Urroz Guerrero, Peter G. Gibson, Hayley Lewthwaite, Eleanor Majellano, Sarah A. Hiles , et al. · 2024

People with severe asthma often lead sedentary lifestyles, which adversely affects overall health and asthma-specific outcomes. To inform future sedentary behaviour- interventions, this study aimed to explore perceptions of sedentary behav…

Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system Open

Laura Mandelli, Yuri Milaneschi, Sarah A. Hiles, Alessandro Serretti, Brenda W.J.H. Penninx · 2022

An unhealthy lifestyle has a critical role in the pathogenesis and course of several chronic disorders. It has been hypothesized that lifestyle may also impact biological systems involved in stress response. A global index of unhealthy lif…

A feasibility randomised controlled trial of Novel Activity Management in severe ASthma-Tailored Exercise (NAMASTE): yoga and mindfulness Open

Sarah A. Hiles, Paola D Urroz Guerrero, Peter G. Gibson, Adam Bogdanovs, Vanessa M. McDonald · 2021

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction Open

Keith W. VanDusen, Yi‐Ju Li, Victor Cai, Ashley Hall, Sarah A. Hiles , et al. · 2021

Background: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1–12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from n…

Dropout from guideline-recommended psychological treatments for posttraumatic stress disorder: A systematic review and meta-analysis Open

Tracey Varker, Kim Jones, Hussain‐Abdulah Arjmand, Mark Hinton, Sarah A. Hiles , et al. · 2021

TMEM67, TMEM237, and Embigin in Complex With Monocarboxylate Transporter MCT1 Are Unique Components of the Photoreceptor Outer Segment Plasma Membrane Open

Nikolai P. Skiba, Martha A. Cady, Laurie L. Molday, John Y.S. Han, Tylor R. Lewis , et al. · 2021

The outer segment (OS) organelle of vertebrate photoreceptors is a highly specialized cilium evolved to capture light and initiate light response. The plasma membrane which envelopes the OS plays vital and diverse roles in supporting photo…

Understanding Clinicians’ Perceived Barriers and Facilitators to Optimal Use of Acute Oxygen Therapy in Adults Open

Joyce L. Cousins, Peter Wark, Sarah A. Hiles, Vanessa M. McDonald · 2020

There is discordance between clinicians' beliefs and actions regarding the administration of oxygen therapy and knowledge gaps about optimal oxygen therapy in acute care. Identified barriers and facilitators should be considered when devel…

Cerebrospinal Fluid Proteomic Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction Open

Keith W. VanDusen, Wenjing Qi, Yi-ju Li, Victor Cai, Ashley Hall , et al. · 2020

Background: Postoperative cognitive dysfunction (POCD) is a syndrome of cognitive deficits that occurs in 10-40% of patients age > 60 within 1-12 months after surgery, hypothesized to be caused in part by neuroinflammation. However, the sp…

Management of acute COPD exacerbations in Australia: do we follow the guidelines? Open

Joyce L. Cousins, Richard Wood‐Baker, Peter Wark, Ian A. Yang, Peter G. Gibson , et al. · 2020

Objective We aimed to assess adherence to the Australian national guideline (COPD-X) against audited practice, and to document the outcomes of patients hospitalised with an acute exacerbation of chronic obstructive pulmonary disease (COPD)…

Does maintenance azithromycin reduce asthma exacerbations? An individual participant data meta-analysis Open

Sarah A. Hiles, Vanessa M. McDonald, Michelle Guilhermino, Guy Brusselle, Peter G. Gibson · 2019

Background Preventing exacerbations is an important goal of asthma treatment. Long-term treatment with azithromycin may help achieve this. Our aim was to conduct a systematic review and individual participant data (IPD) meta-analysis to ex…

Physical activity protects from incident anxiety: A meta‐analysis of prospective cohort studies Open

Felipe Barreto Schuch, Brendon Stubbs, Jacob D. Meyer, Andreas Heißel, Philipp Zech , et al. · 2019

Evidence supports the notion that self-reported PA can confer protection against the emergence of anxiety regardless of demographic factors. In particular, higher PA levels protects from agoraphobia and posttraumatic disorder.

Extrapulmonary associations of health status in severe asthma and bronchiectasis: Comorbidities and functional outcomes Open

Laura Cordova‐Rivera, Peter G. Gibson, Paul A. Gardiner, Sarah A. Hiles, Vanessa M. McDonald · 2019

Treatable traits: a new paradigm for 21st century management of chronic airway diseases: Treatable Traits Down Under International Workshop report Open

Vanessa M. McDonald, James Fingleton, Àlvar Agustí, Sarah A. Hiles, Vanessa Clark , et al. · 2019

“Treatable traits” have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised medicine to each individual to improve outcomes. Moving new treatment approaches …

Treatable traits can be identified in a severe asthma registry and predict future exacerbations Open

Vanessa M. McDonald, Sarah A. Hiles, Krystelle Godbout, Erin S. Harvey, Guy B. Marks , et al. · 2018

Background and objective A new taxonomic and management approach, termed treatable traits, has been proposed for airway diseases including severe asthma. This study examined whether treatable traits could be identified using registry data …

Working while unwell: Workplace impairment in people with severe asthma Open

Sarah A. Hiles, Erin S. Harvey, Vanessa M. McDonald, Matthew Peters, Philip G. Bardin , et al. · 2018

Summary Background Severe asthma affects quality of life; however, its impact on workplace productivity is poorly understood. Objective To compare workplace productivity—absenteeism and presenteeism—and impairment in daily activities in se…

The reciprocal relationship between physical activity and depression: Does age matter? Open

Sanne Wassink‐Vossen, Rose M. Collard, Sarah A. Hiles, Richard C. Oude Voshaar, Paul Naarding · 2018

Background: The level of physical activity (PA) and the prevalence of depression both change across the lifespan. We examined whether the association between PA and depression is moderated by age. As sense of mastery and functional limitat…

Sit, step, sweat: longitudinal associations between physical activity patterns, anxiety and depression Open

Sarah A. Hiles, Femke Lamers, Yuri Milaneschi, Brenda W.J.H. Penninx · 2017

Background Physical inactivity has been identified as a risk factor for depression and, less often, as a long-term consequence of depression. Underexplored is whether similar bi-directional longitudinal relationships are observed for anxie…

Depression and Anxiety Issue Information Open

Karen Lynn Cassiday, D. Jeffrey Newport, Alan F. Schatzberg, Charles B. Nemeroff, Chadi G. Abdallah , et al. · 2016

Basal autonomic activity, stress reactivity, and increases in metabolic syndrome components over time Open

Mandy X. Hu, Femke Lamers, Sarah A. Hiles, Brenda W.J.H. Penninx, Eco J. C. de Geus · 2016

BIDIRECTIONAL PROSPECTIVE ASSOCIATIONS OF METABOLIC SYNDROME COMPONENTS WITH DEPRESSION, ANXIETY, AND ANTIDEPRESSANT USE Open

Sarah A. Hiles, Dóra Révész, Femke Lamers, Erik J. Giltay, Brenda W.J.H. Penninx · 2016

Symptom severity and antidepressant use were independently associated with metabolic dysregulation consistently over time and also had negative consequences for short-term metabolic health. This is of concern given the chronicity of depres…

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