Sarah A. Shelby
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View article: Membrane phase separation drives responsive assembly of receptor signaling domains
Membrane phase separation drives responsive assembly of receptor signaling domains Open
View article: Data from: Membrane phase separation drives responsive assembly of receptor signaling domains
Data from: Membrane phase separation drives responsive assembly of receptor signaling domains Open
Plasma membrane heterogeneity has been tied to a litany of cellular functions and is often explained by analogy to membrane phase separation, yet models based on phase separation alone fall short of describing the rich organization availab…
View article: Data from: Membrane phase separation drives responsive assembly of receptor signaling domains
Data from: Membrane phase separation drives responsive assembly of receptor signaling domains Open
Plasma membrane heterogeneity has been tied to a litany of cellular functions and is often explained by analogy to membrane phase separation, yet models based on phase separation alone fall short of describing the rich organization availab…
View article: Measuring the Co-Localization and Dynamics of Mobile Proteins in Live Cells Undergoing Signaling Responses
Measuring the Co-Localization and Dynamics of Mobile Proteins in Live Cells Undergoing Signaling Responses Open
View article: Abstract 2548: Responsive assembly of signaling domains at the plasma membrane
Abstract 2548: Responsive assembly of signaling domains at the plasma membrane Open
View article: The plasma membrane as an adaptable fluid mosaic
The plasma membrane as an adaptable fluid mosaic Open
View article: Measuring the co-localization and dynamics of mobile proteins in live cells undergoing signaling responses
Measuring the co-localization and dynamics of mobile proteins in live cells undergoing signaling responses Open
ii. Summary/Abstract Single molecule imaging in live cells enables the study of protein interactions and dynamics as they participate in signaling processes. When combined with fluorophores that stochastically transition between fluorescen…
View article: Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function Open
Receptor pathway analysis informs structural modifications to CAR T cells that improve their function.
View article: Membrane phase separation drives organization at B cell receptor clusters
Membrane phase separation drives organization at B cell receptor clusters Open
SUMMARY Heterogeneity in intact cell plasma membranes has been explained by analogy to coexisting liquid-ordered and liquid-disordered phases, although models based on this idea fall short of describing the rich structure within cell membr…
View article: SMAUG: Analyzing single-molecule tracks with nonparametric Bayesian statistics
SMAUG: Analyzing single-molecule tracks with nonparametric Bayesian statistics Open
View article: SMAUG: Analyzing single-molecule tracks with nonparametric Bayesian statistics
SMAUG: Analyzing single-molecule tracks with nonparametric Bayesian statistics Open
Single-molecule fluorescence microscopy probes nanoscale, subcellular biology in real time. Existing methods for analyzing single-particle tracking data provide dynamical information, but can suffer from supervisory biases and high uncerta…
View article: Pair Correlation Analysis of Localization Microscopy Data When Sampling Density is Not Uniform
Pair Correlation Analysis of Localization Microscopy Data When Sampling Density is Not Uniform Open
View article: Phase Partitioning of Peptide Anchors in Plasma Membrane Vesicles Predicts Their Recruitment to B Cell Receptor Clusters in Live Cells
Phase Partitioning of Peptide Anchors in Plasma Membrane Vesicles Predicts Their Recruitment to B Cell Receptor Clusters in Live Cells Open
View article: Functional Organization of Plasma Membrane Adaptor Proteins in B Cell Receptor Signaling
Functional Organization of Plasma Membrane Adaptor Proteins in B Cell Receptor Signaling Open
View article: Super-Resolution Microscopy: Shedding Light on the Cellular Plasma Membrane
Super-Resolution Microscopy: Shedding Light on the Cellular Plasma Membrane Open
Lipids and the membranes they form are fundamental building blocks of cellular life, and their geometry and chemical properties distinguish membranes from other cellular environments. Collective processes occurring within membranes strongl…
View article: Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes
Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes Open
Diverse cellular signaling events, including B cell receptor (BCR) activation, are hypothesized to be facilitated by domains enriched in specific plasma membrane lipids and proteins that resemble liquid-ordered phase-separated domains in m…
View article: Phases and Fluctuations in Biological Membranes
Phases and Fluctuations in Biological Membranes Open
View article: Live Cell Super-Resolution Microscopy Measures Membrane-Driven Sorting of B Cell Receptor Signaling Partners
Live Cell Super-Resolution Microscopy Measures Membrane-Driven Sorting of B Cell Receptor Signaling Partners Open
View article: Author response: Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes
Author response: Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes Open
Article Figures and data Abstract eLife digest Introduction Results Materials and methods References Decision letter Author response Article and author information Metrics Abstract Diverse cellular signaling events, including B cell recept…
View article: Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling
Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling Open
The allergic response is initiated on the plasma membrane of mast cells by phosphorylation of the receptor for immunoglobulin E (IgE), FcεRI, by Lyn kinase after IgE-FcεRI complexes are cross-linked by multivalent antigen. Signal transduct…
View article: Monitoring the Organization, Dynamics, and Interactions of Early B Cell Receptor Signaling Proteins using Live Cell Super-Resolution Microscopy
Monitoring the Organization, Dynamics, and Interactions of Early B Cell Receptor Signaling Proteins using Live Cell Super-Resolution Microscopy Open
View article: Direct Observation of Ordered and Disordered Membrane Domains in B Cell Plasma Membranes using Multi-Color Super-Resolution Fluorescence Microscopy and Application to B Cell Receptor Signaling
Direct Observation of Ordered and Disordered Membrane Domains in B Cell Plasma Membranes using Multi-Color Super-Resolution Fluorescence Microscopy and Application to B Cell Receptor Signaling Open
View article: Super-Resolution Imaging of IgE-FcεRI Stimulated with Structurally Defined Ligands
Super-Resolution Imaging of IgE-FcεRI Stimulated with Structurally Defined Ligands Open