Sarah A. Tersey
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View article: Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility
Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility Open
Whereas most autoimmune diseases exhibit female predominance, type 1 diabetes (T1D) occurs more frequently in males after puberty, suggesting a role for sex hormones in disease modification. Because islet β cells actively shape local immun…
View article: The G Protein-Coupled Receptor GPR31 Promotes Pro-inflammatory Responses in Pancreatic Islets and Macrophages
The G Protein-Coupled Receptor GPR31 Promotes Pro-inflammatory Responses in Pancreatic Islets and Macrophages Open
In type 1 diabetes (T1D), the innate and adaptive immune systems attack and eventually destroy the insulin-secreting pancreatic β cells. During this process, β cells activate inflammatory signaling pathways that augment the dysfunction and…
View article: The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes
The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes Open
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Macrophages infiltrate islets early in T1D pathogenesis, preceding the influx of T- and B-lymphocytes. The integrated …
View article: Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function
Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function Open
Hypusination of eukaryotic translation initiation factor 5A (eIF5A) is essential for its role in translation elongation and termination. Although the function of hypusinated eIF5A (eIF5AHyp) in cellular proliferation is well characterized,…
View article: 12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice
12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice Open
Obesity-associated inflammation is characterized by macrophage infiltration into peripheral tissues, contributing to the progression of prediabetes and type 2 diabetes (T2D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of p…
View article: 12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice Open
Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells and involves an interplay between β cells and cells of the innate and adaptive immune systems. We investigated the therapeutic potential of t…
View article: The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes
The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes Open
Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin producing pancreatic β-cells. Macrophages infiltrate islets early in T1D pathogenesis, preceding the influx of T- and B-lymphocytes. The integrated …
View article: Hypusinated and unhypusinated isoforms of eIF5A exert distinct effects in models of pancreas development and function
Hypusinated and unhypusinated isoforms of eIF5A exert distinct effects in models of pancreas development and function Open
Hypusination of eukaryotic translation initiation factor 5A (eIF5A) is essential for its role in translation elongation and termination. Although the function of hypusinated eIF5A (eIF5A Hyp ) in cellular proliferation is well-characterize…
View article: 12614 Induction Of Gpt2 During Metabolic Stress Is Associated With Reduced Incretin Responsiveness And Decreased β-cell Resilience To Metabolic Stress
12614 Induction Of Gpt2 During Metabolic Stress Is Associated With Reduced Incretin Responsiveness And Decreased β-cell Resilience To Metabolic Stress Open
Disclosure: S. Sen: None. A.V. Rozo: None. M. Haemmerle: None. J. Roman: None. A.V. Scota: None. J.A. Christine: None. E.M. Morrow: None. S.A. Tersey: None. C.B. Newgard: None. N.M. Doliba: None. D.A. Stoffers: None. Elevated blood glucose…
View article: RNA Splicing Events in Circulation Distinguish Individuals With and Without New-onset Type 1 Diabetes
RNA Splicing Events in Circulation Distinguish Individuals With and Without New-onset Type 1 Diabetes Open
Context Alterations in RNA splicing may influence protein isoform diversity that contributes to or reflects the pathophysiology of certain diseases. Whereas specific RNA splicing events in pancreatic islets have been investigated in models…
View article: 12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice
12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice Open
Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells and involves an interplay between β cells and cells of the innate and adaptive immune systems. We investigated the therapeutic potential of t…
View article: Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice
Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice Open
Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms. Cellular stresses, such as nutrient deficiency, viral infection, or unfolded pro…
View article: Discordant Effects of Polyamine Depletion by DENSpm and DFMO on β-cell Cytokine Stress and Diabetes Outcomes in Mice
Discordant Effects of Polyamine Depletion by DENSpm and DFMO on β-cell Cytokine Stress and Diabetes Outcomes in Mice Open
Type 1 diabetes (T1D) is an autoimmune disease leading to dysfunction and loss of insulin-secreting β cells. In β cells, polyamines have been implicated in causing cellular stress and dysfunction. An inhibitor of polyamine biosynthesis, di…
View article: Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice
Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice Open
Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms. Cellular stresses, such as nutrient deficiency, viral infection, or unfolded pro…
View article: FRI613 Sex Differences In Human Islet Transcriptional Responses To Inflammation
FRI613 Sex Differences In Human Islet Transcriptional Responses To Inflammation Open
Disclosure: K.L. Webster: None. W. Wu: None. B. Webb-Robertson: None. E. Nakayasu: None. S. Sarkar: None. C. Evans-Molina: None. S.A. Tersey: None. J. Enriquez: None. S.R. Hammes: None. R.G. Mirmira: None. Higher female incidence of autoim…
View article: SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells
SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells Open
Disclosure: E. Ermis: None. T. Nargis: None. A. Kulkarni: None. S. May: None. S.A. Tersey: None. R.G. Mirmira: None. R.M. Anderson: None. Type 1 diabetes (T1D) is an autoimmune disease, characterized in part by islet inflammation and macro…
View article: THU277 Deletion Or inhibition Of Ornithine Decarboxylase Protects Islet β-cell Health And Is Associated With Preserved Residual C-peptide In Persons With Recent Onset Type 1 Diabetes
THU277 Deletion Or inhibition Of Ornithine Decarboxylase Protects Islet β-cell Health And Is Associated With Preserved Residual C-peptide In Persons With Recent Onset Type 1 Diabetes Open
Disclosure: B. Hammoud: None. L.A. DiMeglio: None. A. Kulkarni: None. A. Hull: None. S. Woerner: None. S. Cabrera: None. L.D. Mastrandrea: None. F. Ouyang: None. S.N. Perkins: None. C. Evans-Molina: None. T.L. Mastracci: None. S.A. Tersey:…
View article: SAT070 The G Protein Coupled Receptor GPR31 Promotes Islet Inflammation And Diabetes
SAT070 The G Protein Coupled Receptor GPR31 Promotes Islet Inflammation And Diabetes Open
Disclosure: C. Checkcinco: None. S.A. Tersey: None. R.G. Mirmira: None. In type 1 diabetes a characteristic immune response targets insulin secreting beta cells in pancreatic islets, resulting in their destruction. This pathogenesis featur…
View article: SAT071 Inhibition Of 12 Lipoxygenase In A Humanized Mouse Model Of Type 1 Diabetes Delays Progression Of Hyperglycemia
SAT071 Inhibition Of 12 Lipoxygenase In A Humanized Mouse Model Of Type 1 Diabetes Delays Progression Of Hyperglycemia Open
Disclosure: T. Nargis: None. A. Chakraborty: None. K. Figatner: None. D. Maloney: None. M. Boxer: None. S.A. Tersey: None. R.G. Mirmira: None. Type 1 diabetes (T1D) is an autoimmune disorder characterized by islet inflammation (insulitis).…
View article: OR12-01 Blocking The Maladaptive Integrated Stress Response Increases Immunosuppressive PD-L1 In Pancreatic β-Cells
OR12-01 Blocking The Maladaptive Integrated Stress Response Increases Immunosuppressive PD-L1 In Pancreatic β-Cells Open
Disclosure: C. Muralidharan: None. F.H. huang: None. S.C. May: None. J. Enriquez: None. J.B. Nelson: None. E. Wang: None. A. Chakraborthy: None. K.T. Figatner: None. S.N. Navitskaya: None. S.A. Tersey: None. R.G. Mirmira: None. In type 1 d…
View article: SAT075 Beta Cells Adapt To Insulin Resistance Via Posttranslational Modification Of The Translation Factor eIF5A
SAT075 Beta Cells Adapt To Insulin Resistance Via Posttranslational Modification Of The Translation Factor eIF5A Open
Disclosure: C. Anderson: None. A. Kulkarni: None. B. Maier: None. S.A. Tersey: None. R. Anderson: None. R.G. Mirmira: None. Prior to type 2 diabetes onset, β cells adapt to insulin resistance through compensation—a process that maintains i…
View article: SAT068 The Golgi Transmembrane Protein GOLM1 Maintains PD-L1 Protein Levels In Islet Beta Cells In Response To Type 1 Diabetic Inflammation
SAT068 The Golgi Transmembrane Protein GOLM1 Maintains PD-L1 Protein Levels In Islet Beta Cells In Response To Type 1 Diabetic Inflammation Open
Disclosure: F. huang: None. J. Nelson: None. C. Muralidharan: None. E. Nakayasu: None. X. Yi: None. D. Eizirik: None. S. May: None. S.A. Tersey: None. R.G. Mirmira: None. In type 1 diabetes (T1D), a dialog between β cells and immune cells …
View article: Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinoma
Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinoma Open
Background Early detection and intervention research is expected to improve the outcomes for patients with high grade muscle invasive urothelial carcinoma (InvUC). With limited patients in suitable high-risk study cohorts, relevant animal …