Sarah Bär
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View article: Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes
Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes Open
Background Coronary artery disease (CAD) is a major contributor to cardiovascular events in individuals with diabetes. Quantification of coronary atherosclerotic burden is now feasible from coronary computed tomography angiography (CTA) wh…
View article: Effect of alirocumab on coronary plaque stratified by atherothrombotic risk
Effect of alirocumab on coronary plaque stratified by atherothrombotic risk Open
Among AMI patients, the addition of alirocumab to high-intensity statin therapy resulted in greater coronary plaque regression and lipid burden reduction in patients not at VHR. Further investigation is needed to clarify the impact of athe…
View article: Association of body mass index on 10-year outcomes in patients treated with percutaneous coronary intervention and drug-eluting stents (the DECADE cooperation)
Association of body mass index on 10-year outcomes in patients treated with percutaneous coronary intervention and drug-eluting stents (the DECADE cooperation) Open
Aims To assess the association between body mass index (BMI) and 10-year clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation. Methods This is a pooled analysis of fiv…
View article: Prognostic Value of a Coronary Computed Tomography Angiography–Derived Ischemia Algorithm: Comparison Against Hybrid Coronary Computed Tomography Angiography/Positron Emission Tomography Imaging
Prognostic Value of a Coronary Computed Tomography Angiography–Derived Ischemia Algorithm: Comparison Against Hybrid Coronary Computed Tomography Angiography/Positron Emission Tomography Imaging Open
Background Artificial intelligence–guided quantitative computed tomography ischemia (AI‐QCT ischemia ) is a novel machine‐learning method for predicting myocardial ischemia from coronary computed tomography angiography (CCTA). This observa…
View article: Coronary artery stenosis, plaque burden, and severity of myocardial ischemia
Coronary artery stenosis, plaque burden, and severity of myocardial ischemia Open
Aims The relationship between the extent and composition of coronary atherosclerosis and the severity of myocardial ischaemia remains incompletely understood. We assessed whether artificial intelligence-guided coronary computed tomography …
View article: Coronary artery stenosis, plaque burden, and severity of myocardial ischemia.
Coronary artery stenosis, plaque burden, and severity of myocardial ischemia. Open
Aims The relationship between the extent and composition of coronary atherosclerosis and the severity of myocardial ischaemia remains incompletely understood. We assessed whether artificial intelligence-guided coronary computed tomography …
View article: Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories
Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories Open
The degree of stenosis and atherosclerotic burden are significantly higher in the LAD as compared to LCX and RCA, both in epicardial coronary arteries supplying nonischemic or ischemic myocardial territories. In all the three main coronary…
View article: Intake of high-intensity statin after acute myocardial infarction assessed by direct drug concentration measurement: association with LDL-C response and coronary plaque modifications in the PACMAN-AMI trial
Intake of high-intensity statin after acute myocardial infarction assessed by direct drug concentration measurement: association with LDL-C response and coronary plaque modifications in the PACMAN-AMI trial Open
Background In real-world settings, adherence to preventive cardiovascular medications is often suboptimal. However, in clinical trials, adherence is crucial for ensuring the validity and generalizability of study results, and their clinica…
View article: Derivation and validation of an artificial intelligence-based plaque burden safety cut-off for long-term acute coronary syndrome from coronary computed tomography angiography
Derivation and validation of an artificial intelligence-based plaque burden safety cut-off for long-term acute coronary syndrome from coronary computed tomography angiography Open
Aims Artificial intelligence (AI) has enabled accurate and fast plaque quantification from coronary computed tomography angiography (CCTA). However, AI detects any coronary plaque in up to 97% of patients. To avoid overdiagnosis, a plaque …
View article: Ten‐year clinical outcomes after drug‐eluting stents implantation according to clinical presentation—Insights from the <scp>DECADE</scp> cooperation
Ten‐year clinical outcomes after drug‐eluting stents implantation according to clinical presentation—Insights from the <span>DECADE</span> cooperation Open
Background Investigations of very long‐term outcomes after percutaneous coronary intervention (PCI) with drug‐eluting stents (DES) according to clinical presentation are scarce. Here, we investigated the 10‐year clinical outcomes of patien…
View article: Factors affecting the performance of a novel artificial intelligence-based coronary computed tomography-derived ischaemia algorithm
Factors affecting the performance of a novel artificial intelligence-based coronary computed tomography-derived ischaemia algorithm Open
Aims AI-QCTischaemia is an FDA-cleared novel artificial intelligence–guided method that utilizes features from coronary computed tomography angiography (CCTA) to predict myocardial ischaemia. Objective To identify factors associated with d…
View article: Effect of alirocumab on coronary plaque stratified by atherothrombotic risks
Effect of alirocumab on coronary plaque stratified by atherothrombotic risks Open
Background Previous clinical studies have shown that high-risk subgroups including patients with major atherosclerotic cardiovascular disease (ASCVD) events and multiple atherothrombotic risk factors derive enhanced cardiovascular benefit …
View article: Incremental diagnostic value of a novel artificial intelligence-based ischemia algorithm to predict myocardial ischemia from CCTA
Incremental diagnostic value of a novel artificial intelligence-based ischemia algorithm to predict myocardial ischemia from CCTA Open
Background Coronary computed tomography angiography (CCTA) is known to be limited in assessing the hemodynamic significance of a coronary artery stenosis. A novel artificial intelligence (AI)-based CCTA-derived algorithm (AI-QCTischemia) a…
View article: Incremental prognostic value of artificial intelligence-based automated plaque characterisation on top of ischemia evaluation by CCTA and CCTA/PET
Incremental prognostic value of artificial intelligence-based automated plaque characterisation on top of ischemia evaluation by CCTA and CCTA/PET Open
Background Artificial intelligence (AI)-based quantitative computed tomography (AI-QCT) is a novel tool for automated plaque characterisation and quantitation from coronary computed tomography angiography (CCTA). The prognostic value of va…
View article: Prognostic value of a novel artificial intelligence-based coronary CTA-derived ischemia algorithm among patients with normal or abnormal myocardial perfusion
Prognostic value of a novel artificial intelligence-based coronary CTA-derived ischemia algorithm among patients with normal or abnormal myocardial perfusion Open
Among patients with obstructive CAD on coronary CTA referred for downstream 15O-H2O-PET perfusion imaging, AI-QCTischemia showed incremental prognostic value among patients with preserved perfusion by 15O-H2O-PET imaging, but not among tho…
View article: Effects of alirocumab on endothelial function and coronary atherosclerosis in myocardial infarction: A PACMAN-AMI randomized clinical trial substudy
Effects of alirocumab on endothelial function and coronary atherosclerosis in myocardial infarction: A PACMAN-AMI randomized clinical trial substudy Open
Among patients with AMI, the addition of alirocumab did not result in further improvement of FMD as compared to 52 weeks secondary preventative medical therapy including high-intensity statin therapy. FMD was significantly associated with …
View article: Quantitative Flow Ratio to Predict Non–Target‐Vessel Events Before Planned Staged Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome
Quantitative Flow Ratio to Predict Non–Target‐Vessel Events Before Planned Staged Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome Open
Background The optimal time point of staged percutaneous coronary intervention (PCI) among patients with acute coronary syndrome (ACS) remains a matter of debate. Quantitative flow ratio (QFR) is a novel noninvasive method to assess the he…
View article: Prognostic value of a novel artificial intelligence-based coronary computed tomography angiography-derived ischaemia algorithm for patients with suspected coronary artery disease
Prognostic value of a novel artificial intelligence-based coronary computed tomography angiography-derived ischaemia algorithm for patients with suspected coronary artery disease Open
Aims Coronary computed tomography angiography (CTA) imaging is used to diagnose patients with suspected coronary artery disease (CAD). A novel artificial intelligence-guided quantitative computed tomography ischaemia algorithm (AI-QCTischa…
View article: Quantitative Flow Ratio to Predict Non-Target-Vessel Events Prior to Planned Staged PCI in ACS Patients
Quantitative Flow Ratio to Predict Non-Target-Vessel Events Prior to Planned Staged PCI in ACS Patients Open
Background The optimal timepoint of staged percutaneous coronary intervention (sPCI) among patients with acute coronary syndrome (ACS) and multivessel disease (MVD) remains a matter of debate. Quantitative Flow Ratio (QFR) is a novel non-i…
View article: Impact of alirocumab on plaque regression and haemodynamics of non-culprit arteries in patients with acute myocardial infarction: a prespecified substudy of the PACMAN-AMI trial
Impact of alirocumab on plaque regression and haemodynamics of non-culprit arteries in patients with acute myocardial infarction: a prespecified substudy of the PACMAN-AMI trial Open
gov: NCT03067844.
View article: Clinical outcomes in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary interventions later than 48 h after symptom onset
Clinical outcomes in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary interventions later than 48 h after symptom onset Open
Aims Routine revascularization in patients with ST-segment elevation myocardial infarction (STEMI) presenting >48 h after symptom onset is not recommended. Methods and results We compared outcomes of STEMI patients undergoing percutaneo…
View article: Sex Differences in 10-Year Outcomes After Percutaneous Coronary Intervention With Drug-Eluting Stents: Insights From the DECADE Cooperation
Sex Differences in 10-Year Outcomes After Percutaneous Coronary Intervention With Drug-Eluting Stents: Insights From the DECADE Cooperation Open
Background: Although some studies have investigated sex-related outcomes up to 5 years after percutaneous coronary intervention (PCI), analyses at longer follow-up (ie, to 10 years) in large cohorts treated exclusively with drug-eluting st…
View article: Impact of alirocumab added to high-intensity statin therapy on platelet function in AMI patients: a pre-specified substudy of the randomized, placebo-controlled PACMAN-AMI trial
Impact of alirocumab added to high-intensity statin therapy on platelet function in AMI patients: a pre-specified substudy of the randomized, placebo-controlled PACMAN-AMI trial Open
Background Previous small observational studies have suggested a potential association of proprotein convertase subtilisin kexin type 9 (PCSK9) and platelet reactivity. However, the role of the PCSK9 inhibitor alirocumab on platelet aggreg…
View article: Transient injection site reaction to alirocumab during immune system activation: a case series
Transient injection site reaction to alirocumab during immune system activation: a case series Open
Background Injection site reactions (ISRs) are known side effects of the proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor alirocumab. Transient ISR to alirocumab after a long phase of good tolerability have not been reported prev…