Sarah Bowman
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View article: Quantifying the prevalence and determinants of respiratory syncytial virus (RSV) vaccine hesitancy in US adults aged 60 or older
Quantifying the prevalence and determinants of respiratory syncytial virus (RSV) vaccine hesitancy in US adults aged 60 or older Open
View article: Pipe(line) dreams for MicroED/3DED sample preparation
Pipe(line) dreams for MicroED/3DED sample preparation Open
Microcrystal electron diffraction (MicroED) has experienced incredible growth as a powerful technique for structure determination. Similar to all diffraction-based structural methods for biomolecules, a bottleneck in using MicroED to solve…
View article: Does crossing the pond affect crystal quality?
Does crossing the pond affect crystal quality? Open
Room-temperature (RT) X-ray diffraction experiments enable us to investigate protein dynamics, efficiently probe fragment binding, and perform time-resolved crystallography experiments. The Versatile Macromolecular Crystallography in-situ …
View article: <i>Burkholderia pseudomallei</i> rubrerythrin promiscuously binds metals in a structurally pre-formed bimetallic binding site
<i>Burkholderia pseudomallei</i> rubrerythrin promiscuously binds metals in a structurally pre-formed bimetallic binding site Open
Rubrerythrins are a group of proteins within the Ferritin-like superfamily that display a defining four-helix bundle domain. They also show multiple structural features that are crucial to their functionality as iron storage proteins and i…
View article: Preparing for successful protein crystallization experiments
Preparing for successful protein crystallization experiments Open
Crystal-based structural methods, including X-ray crystallography, are frequently utilized for the determination of high-resolution structures of biomolecules. All crystal-based diffraction methods first require the preparation of biomolec…
View article: Don't Panic! Navigating Scientific Peer Review
Don't Panic! Navigating Scientific Peer Review Open
Scientific peer review is a crucial component of the scientific dialogue and of doing science. As scientists, we've all experienced both good and bad reviews when submitting our research for publication. In this talk we'll cover some ‘Best…
View article: Striving to Meet the Needs of the Structural Biology Community at the National Crystallization Center
Striving to Meet the Needs of the Structural Biology Community at the National Crystallization Center Open
The National Crystallization Center at HWI seeks to serve the structural biology community by providing low-cost, high-throughput crystallographic screening to overcome the bottleneck of macromolecular crystallization. Our primary service,…
View article: Metalloproteins in emerging pathogens
Metalloproteins in emerging pathogens Open
Pathogens, such as bacteria, viruses, fungi, and protozoa, are constantly evolving and novel healthcare threats are frequently identified. The current race to find novel antimicrobials and overcome drug resistance is yet to win over the co…
View article: Establishing a MicroED workflow at the Hauptman-Woodward Institute
Establishing a MicroED workflow at the Hauptman-Woodward Institute Open
The Cryo-EM Center at the Hauptman-Woodward Institute is a full-service facility serving internal, academic, and industry users. In collaboration with experts at the National High-Throughput Crystallization (HTX) Center at HWI we are worki…
View article: Promoting Annual COVID-19 Vaccine Uptake in Unvaccinated Populations Through Effective Communication
Promoting Annual COVID-19 Vaccine Uptake in Unvaccinated Populations Through Effective Communication Open
Importance: While high levels of annual vaccination remains a key strategy for preventing the spread of new COVID-19 variants, most eligible Americans chose not to receive an updated vaccine in 2023. Objective: To assess the effectiveness …
View article: Preparing research samples for safe arrival at centers and facilities: recipes for successful experiments
Preparing research samples for safe arrival at centers and facilities: recipes for successful experiments Open
Preparation of biomacromolecules for structural biology studies is a complex and time-consuming process. The goal is to produce a highly concentrated, highly pure product that is often shipped to large facilities with tools to prepare the …
View article: Postoperative anaemia increases unplanned readmission: an international prospective cohort study of patients undergoing major abdominal surgery
Postoperative anaemia increases unplanned readmission: an international prospective cohort study of patients undergoing major abdominal surgery Open
View article: Reaching the potential of electron diffraction
Reaching the potential of electron diffraction Open
Microcrystal electron diffraction (MicroED) is an emerging structural technique in which submicron crystals are used to generate diffraction data for structural studies. Structures allow for the study of molecular-level architecture and dr…
View article: Applying 3D ED/MicroED workflows toward the next frontiers
Applying 3D ED/MicroED workflows toward the next frontiers Open
We report on the latest advancements in Microcrystal Electron Diffraction (3D ED/MicroED), as discussed during a symposium at the National Center for CryoEM Access and Training housed at the New York Structural Biology Center. This snapsho…
View article: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography Open
X-ray crystallography is the most commonly employed technique to discern macromolecular structures, but the crucial step of crystallizing a protein into an ordered lattice amenable to diffraction remains challenging. The crystallization of…
View article: 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening
20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening Open
Diffraction-based structural methods contribute a large fraction of the biomolecular structural models available, providing a critical understanding of macromolecular architecture. These methods require crystallization of the target molecu…
View article: Abstract 2700: Getting vanishingly small crystals to stop vanishing: Imaging and analysis for cutting edge structural methods
Abstract 2700: Getting vanishingly small crystals to stop vanishing: Imaging and analysis for cutting edge structural methods Open
View article: Abstract 2428: Structural investigations of rubrerythrin from B. pseudomallei: Metals, domain swapping, and other interesting features of this ferritin-like superfamily protein
Abstract 2428: Structural investigations of rubrerythrin from B. pseudomallei: Metals, domain swapping, and other interesting features of this ferritin-like superfamily protein Open
View article: Computational identification of a systemic antibiotic for Gram-negative bacteria
Computational identification of a systemic antibiotic for Gram-negative bacteria Open
View article: The National High-Throughput Crystallization Center and coming hands-on workshops
The National High-Throughput Crystallization Center and coming hands-on workshops Open
Workshops designed to engage with the structural biology community are critical for providing support and training to new researchers in the field.One of the important aspects of any structure pipeline is often sample preparation; in diffr…
View article: Advances using machine learning and computational tools for crystal growth and detection
Advances using machine learning and computational tools for crystal growth and detection Open
While there is much focus on how machine learning (ML) can assist analysis of structural datasets from diffraction and microscopy experiments, less recognized is the contribution of ML methods to upstream stages of the structure determinat…
View article: Statewide Evaluation of SARS-CoV-2 Diagnoses and Sexual Orientation and Gender Identity
Statewide Evaluation of SARS-CoV-2 Diagnoses and Sexual Orientation and Gender Identity Open
Objective: Understanding and identifying disparities in COVID-19 testing outcomes can help allocate resources to where they are most needed. The objective of this study was to estimate the association between lesbian, gay, bisexual, transg…
View article: COVID-19 associated pancreatitis: A mini case-series
COVID-19 associated pancreatitis: A mini case-series Open
View article: Performance-Based Adaptive Automation: Number of Task Types and Response Time Measures Triggering Level of Automation Changes
Performance-Based Adaptive Automation: Number of Task Types and Response Time Measures Triggering Level of Automation Changes Open
A key challenge facing automation designers is how to achieve an ideal balance of system automation with human interaction for optimal operator decision making and system performance. A performance-based adaptive automation algorithm was e…
View article: The ideal crystal for structural biology
The ideal crystal for structural biology Open
The ideal crystal for structural biology can be defined as one that diffracts to sufficient resolution and completeness to answer the biological question being asked.While simply stated, that question can be asked in many ways and there is…
View article: Pushing the boundaries in crystallization screening: making automated user-accessible crystallization work
Pushing the boundaries in crystallization screening: making automated user-accessible crystallization work Open
The Crystallization Center at
View article: Modeling and machine learning tools to improve image processing in crystallization screening
Modeling and machine learning tools to improve image processing in crystallization screening Open
Imaging methods are vital to the process of screening for successful crystallization hits.When screening is carried out in a high-throughput manner, the sheer volume of images needing processing is enormous, requiring a large commitment of…
View article: Structural biology in the time of COVID-19: perspectives on methods and milestones
Structural biology in the time of COVID-19: perspectives on methods and milestones Open
The global COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has wreaked unprecedented havoc on global society, in terms of a huge loss of life and burden of morbidity, economic upheaval and social di…
View article: Beginning Restorative Activities Very Early: Implementation of an Early Mobility Initiative in a Pediatric Onco-Critical Care Unit
Beginning Restorative Activities Very Early: Implementation of an Early Mobility Initiative in a Pediatric Onco-Critical Care Unit Open
Introduction Children with underlying oncologic and hematologic diseases who require critical care services have unique risk factors for developing functional impairments from pediatric post-intensive care syndrome (PICS-p). Early mobiliza…
View article: Re-open our city and campus post-Covid: A case study of Trinity college Dublin, the University of Dublin
Re-open our city and campus post-Covid: A case study of Trinity college Dublin, the University of Dublin Open
Dublin, Ireland, like most other large cities has undergone lockdown due to the outbreak of the coronavirus. Ongoing physical distancing requirements, as cities reopens, has resulted in a collapse to transit's capacity and ability to meet …