Sarah C. Edwards
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View article: IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors
IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors Open
In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host defense and anti-tumor immunity. Un…
View article: IL-27 maintains cytotoxic Ly6C <sup>+</sup> γδ T cells that arise from immature precursors
IL-27 maintains cytotoxic Ly6C <sup>+</sup> γδ T cells that arise from immature precursors Open
In mice, γδ T cells that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage in the thymus, and in the periphery, these cells play a critical role in host defence and anti-tumor immunity. Unlike αβ T cell…
View article: ERBB signalling contributes to immune evasion in KRAS-driven lung adenocarcinoma
ERBB signalling contributes to immune evasion in KRAS-driven lung adenocarcinoma Open
Immunotherapy is increasingly viewed as treatment of choice for lung cancer, however, clinical responses to immune checkpoint blockade remain highly unpredictable and are largely transient. A deeper mechanistic understanding of the dynamic…
View article: PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells
PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells Open
IL-17A–producing γδ T cells in mice consist primarily of Vγ6+ tissue-resident cells and Vγ4+ circulating cells. How these γδ T cell subsets are regulated during homeostasis and cancer remains poorly understood. Using single-cell RNA sequen…
View article: NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression
NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression Open
γδT cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance, homeostasis, and cancer. γδT cells recognize stressed cells or cancer cells through the NKG2D receptor to kil…
View article: NKG2D signaling regulates IL-17A-producing γδT cells to promote cancer progression
NKG2D signaling regulates IL-17A-producing γδT cells to promote cancer progression Open
γδT cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance and homeostasis. γδT cell activation is mediated by the T cell receptor composed of γ and δ chains, as well as…
View article: Single-cell analysis uncovers differential regulation of lung γδ T cell subsets by the co-inhibitory molecules, PD-1 and TIM-3
Single-cell analysis uncovers differential regulation of lung γδ T cell subsets by the co-inhibitory molecules, PD-1 and TIM-3 Open
IL-17A-producing γδ T cells within the lung consist of both Vγ6 + tissue-resident cells and Vγ4 + circulating cells that play important roles in homeostasis, inflammation, infection, tumor progression and metastasis. How these γδ T cell su…
View article: Emerging immunotherapies for metastasis
Emerging immunotherapies for metastasis Open
Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types…
View article: Ly6C defines a subset of memory-like CD27<sup>+</sup>γδ T cells with inducible cancer-killing function
Ly6C defines a subset of memory-like CD27<sup>+</sup>γδ T cells with inducible cancer-killing function Open
In mice, IFNγ-producing γδ T cells that express the co-stimulatory molecule, CD27, play a critical role in host defence and anti-tumour immunity. However, their phenotypic diversity, composition in peripheral and secondary lymphoid organs,…
View article: A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans
A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans Open
T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by d…
View article: Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells
Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells Open
View article: P2.03-14 Developing an Immunogenic Model of Non Small Cell Lung Cancer
P2.03-14 Developing an Immunogenic Model of Non Small Cell Lung Cancer Open
View article: γδ T Cells and NK Cells – Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity
γδ T Cells and NK Cells – Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity Open
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease that affects the central nervous system (CNS) resulting in progressive cognitive decline and physical disability. Experimental autoimmune encephalomyelitis (EAE) is a…
View article: Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction
Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction Open
Infection with viral or bacterial pathogens has been linked with the development of multiple sclerosis (MS), while infection with helminth parasites has been associated protection against MS and other autoimmune diseases. Here we have used…
View article: The role of T cell subsets in experimental autoimmune encephalomyelitis
The role of T cell subsets in experimental autoimmune encephalomyelitis Open
Multiple Sclerosis (MS) is a chronic, demyelinating disease which affects the central nervous system (CNS) resulting in progressive cognitive decline and physical disability. Experimental autoimmune encephalomyelitis (EAE) is an animal mod…