Sarah C. Linn
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View article: Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling
Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling Open
Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse mo…
View article: PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses
PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses Open
Despite advancements in our understanding of urinary tract infection (UTI) pathogenesis, UTIs remain a leading cause of morbidity, partly because of an incomplete understanding of the molecular pathways governing bladder antibacterial defe…
View article: Obesity promotes urinary tract infection by disrupting urothelial immune defenses
Obesity promotes urinary tract infection by disrupting urothelial immune defenses Open
Obesity is a significant public health concern that is associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms responsible for increased infection risk are poorly defined. Here, we use a di…
View article: Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic Leptospira methyl-accepting chemotaxis protein following challenge
Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic Leptospira methyl-accepting chemotaxis protein following challenge Open
Leptospirosis is the most widespread zoonosis and a life-threatening disease in humans and animals. Licensed killed whole-cell vaccines are available for animals; however, they do not offer heterologous protection, do not induce long-term …
View article: Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic<i>Leptospira</i>methyl-accepting chemotaxis protein following challenge
Enhancement of clinical signs in C3H/HeJ mice vaccinated with a highly immunogenic<i>Leptospira</i>methyl-accepting chemotaxis protein following challenge Open
Leptospirosis is the most widespread zoonosis and a life-threating disease of humans and animals. Licensed killed whole-cell vaccines are available for animals; however, they do not offer heterologous protection, do not induce a long-term …
View article: Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection Open
Urinary tract infections (UTIs) commonly afflict people with diabetes. To better understand the mechanisms that predispose diabetics to UTIs, we employ diabetic mouse models and altered insulin signaling to show that insulin receptor (IR) …
View article: Pre-clinical evaluation of biomarkers for the early detection of nephrotoxicity following alpha-particle radioligand therapy
Pre-clinical evaluation of biomarkers for the early detection of nephrotoxicity following alpha-particle radioligand therapy Open
Purpose Cancer treatment with alpha-emitter-based radioligand therapies (α-RLTs) demonstrates promising tumor responses. Radiolabeled peptides are filtered through glomeruli, followed by potential reabsorption of a fraction by proximal tub…
View article: Pre-clinical Evaluation of Biomarkers for Early Detection of Nephrotoxicity Following Alpha-particle Radioligand Therapy
Pre-clinical Evaluation of Biomarkers for Early Detection of Nephrotoxicity Following Alpha-particle Radioligand Therapy Open
Purpose Cancer treatment with alpha-emitter-based radioligand therapies (α-RLTs) demonstrates promising tumor responses. Radiolabeled peptides are filtered through glomeruli, followed by potential reabsorption of a fraction by proximal tub…
View article: Ingesta-associated choledocholithiasis in horses: 2 cases and literature review
Ingesta-associated choledocholithiasis in horses: 2 cases and literature review Open
Equine ingesta-associated choledocholithiasis is a rare cause of morbidity and mortality. We describe here the clinical, gross, histologic, and microbiologic features of this condition in 2 horses and compare the features to 2 previous cas…
View article: Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection
Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection Open
With the emergence of antibiotic-resistant bacteria, innovative approaches are needed for the treatment of urinary tract infections. Boosting antimicrobial peptide expression may provide an alternative to antibiotics. Here, we developed re…
View article: Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenic <i>Escherichia coli</i> challenge
Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenic <i>Escherichia coli</i> challenge Open
Antimicrobial peptides (AMPs) are critical to the protection of the urinary tract of humans and other animals from pathogenic microbial invasion. AMPs rapidly destroy pathogens by disrupting microbial membranes and/or augmenting or inhibit…
View article: Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumours
Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumours Open
Currently, intraoperative tumour margin imaging is not routinely utilized in veterinary medicine. Optical coherence tomography (OCT) allows for real‐time assessment of tissue morphology of 1–2 mm depth. The aims of this study were (1) to c…
View article: Mitogen-activated protein kinase phosphatase-1 controls PD-L1 expression by regulating type I interferon during systemic Escherichia coli infection
Mitogen-activated protein kinase phosphatase-1 controls PD-L1 expression by regulating type I interferon during systemic Escherichia coli infection Open
Mitogen-activated protein kinase phosphatase 1 (Mkp-1) KO mice produce elevated cytokines and exhibit increased mortality and bacterial burden following systemic Escherichia coli infection. To understand how Mkp-1 affects immune defense, w…
View article: Case Report: Use of PET/CT to Guide Treatment in a Cat With Presentation Consistent With Hodgkin's-Like Lymphoma
Case Report: Use of PET/CT to Guide Treatment in a Cat With Presentation Consistent With Hodgkin's-Like Lymphoma Open
An 8-year-old male neutered Domestic Long Hair cat was presented for a cervical swelling that was suspected to be an enlarged left retropharyngeal lymph node. In the absence of other lymphadenopathy, this was initially suspected to be Hodg…
View article: Diagnostic accuracy of optical coherence tomography for assessing surgical margins of canine soft tissue sarcomas in observers of different specialties
Diagnostic accuracy of optical coherence tomography for assessing surgical margins of canine soft tissue sarcomas in observers of different specialties Open
Objective To determine the diagnostic accuracy of optical coherence tomography (OCT) to assess surgical margins of canine soft tissue sarcoma (STS) and determine the influence of observer specialty and training. Study design Blinded clinic…
View article: Nail abnormalities identified in an ageing study of 30 inbred mouse strains
Nail abnormalities identified in an ageing study of 30 inbred mouse strains Open
In a large‐scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON…