Explanipedia

Part 6: Pediatric Basic Life Support: 2025 American Heart Association and American Academy of Pediatrics Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Open

Benny L. Joyner, Maya Dewan, Aarti Bavare, Allan de Caen, Kimberly DiMaria , et al. · 2025

Codeveloped by the American Heart Association and the American Academy of Pediatrics, this publication presents the 2025 guidelines for basic life support during cardiopulmonary resuscitation and emergency cardiovascular care of the pediat…

Sertraline-induced 5-HT dysregulation in mouse cardiomyocytes and the impact on calcium handling Open

Yongjun Lu, Elizabeth J. Kenkel, Kathy Zimmerman, Robert M. Weiss, Robert D. Roghair , et al. · 2024

Sertraline exposure during development decreased the expression of critical genes in calcium regulation and lengthened periods in calcium oscillation in neonatal cardiomyocytes. Sertraline upregulated specific microRNAs that may modulate s…

Association between survival and number of shocks for pulseless ventricular arrhythmias during pediatric in-hospital cardiac arrest in a national registry Open

Sarah E. Haskell, Derek B. Hoyme, M. Bridget Zimmerman, Ron Reeder, Saket Girotra , et al. · 2024

One hand open palm technique for infant CPR Open

Shruti Patel, Shilpa Balikai, Timothy G. Elgin, Elizabeth A. Newell, Tarah T. Colaizy , et al. · 2023

Background The guideline recommended chest compression depth, rate, and recoil are essential factors for the return of spontaneous circulation (ROSC) in cardiopulmonary resuscitation (CPR). A pediatric resuscitation collaboration recently …

Hypersensitivity of Zebrafish htr2b Mutant Embryos to Sertraline Indicates a Role for Serotonin Signaling in Cardiac Development Open

Mitchell E. Kent, Bo Hu, Timothy M. Eggleston, Ryan S. Squires, Kathy A. Zimmerman , et al. · 2022

Selective serotonin reuptake inhibitors (SSRIs) are antidepressants prescribed in 10% of pregnancies in the United States. Maternal use of SSRIs has been linked to an elevated rate of congenital heart defects, but the exact mechanism of pa…

Association of chest compression pause duration prior to E-CPR cannulation with cardiac arrest survival outcomes Open

Kasper Glerup Lauridsen, Javier J. Lasa, Tia T. Raymond, Priscilla Yu, Dana Niles , et al. · 2022

Effect of Amplitude Spectral Area on Termination of Fibrillation and Outcomes in Pediatric Cardiac Arrest Open

Tia T. Raymond, Sandeep V. Pandit, Heather Griffis, Xuemei Zhang, Richard Hanna , et al. · 2021

Background Amplitude spectral area (AMSA) predicts termination of fibrillation (TOF) with return of spontaneous circulation (ROSC) and survival in adults but has not been studied in pediatric cardiac arrest. We characterized AMSA during pe…

2019 American Heart Association focused update on pediatric advanced life support: An update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care Open

J.P. Duff, A.A. Topjian, M.D. Berg, M. Chan, Sarah E. Haskell , et al. · 2021

This 2019 focused update to the American Heart Association pediatric advanced life support guidelines follows the 2018 and 2019 systematic reviews performed by the Pediatric Life Support Task Force of the International Liaison Committee on…

2018 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Open

J.P. Duff, A. Topjian, M.D. Berg, M. Chan, Sarah E. Haskell , et al. · 2021

This 2018 American Heart Association focused update on pediatric advanced life support guidelines for cardiopulmonary resuscitation and emergency cardiovascular care follows the 2018 evidence review performed by the Pediatric Task Force of…

Racial disparities in survival outcomes following pediatric in-hospital cardiac arrest Open

Sarah E. Haskell, Saket Girotra, Yunshu Zhou, M. Bridget Zimmerman, Marina Del Rios , et al. · 2021

2019 American Heart Association Focused Update on Pediatric Basic Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Open

Jonathan P. Duff, Alexis Topjian, Marc Berg, Melissa Chan, Sarah E. Haskell , et al. · 2019

This 2019 focused update to the American Heart Association pediatric basic life support guidelines follows the 2019 systematic review of the effects of dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) on survival of infants and c…

2019 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Open

Jonathan P. Duff, Alexis Topjian, Marc Berg, Melissa Chan, Sarah E. Haskell , et al. · 2019

This 2019 focused update to the American Heart Association pediatric advanced life support guidelines follows the 2018 and 2019 systematic reviews performed by the Pediatric Life Support Task Force of the International Liaison Committee on…

Pediatric Post–Cardiac Arrest Care: A Scientific Statement From the American Heart Association Open

Alexis Topjian, Allan de Caen, Mark S. Wainwright, Benjamin S. Abella, Nicholas S. Abend , et al. · 2019

Successful resuscitation from cardiac arrest results in a post–cardiac arrest syndrome, which can evolve in the days to weeks after return of sustained circulation. The components of post–cardiac arrest syndrome are brain injury, myocardia…

Code Team Structure and Training in the Pediatric Resuscitation Quality International Collaborative Open

Stephen Pfeiffer, Kasper Glerup Lauridsen, Jesse Wenger, Elizabeth A. Hunt, Sarah E. Haskell , et al. · 2019

Objectives Code team structure and training for pediatric in-hospital cardiac arrest are variable. There are no data on the optimal structure of a resuscitation team. The objective of this study is to characterize the structure and trainin…

Origins of neonatal leptin deficiency in preterm infants Open

Baiba Steinbrekera, Tarah T. Colaizy, Lauren K. Vasilakos, Karen Johnson, Donna A. Santillan , et al. · 2019

Neonatal Growth Restriction Slows Cardiomyocyte Development and Reduces Adult Heart Size Open

Madeline H. Knott, Sarah E. Haskell, Payton E. Strawser, Olivia M. Rice, Natalie T. Bonthius , et al. · 2018

Prematurity is associated with reduced cardiac dimensions and an increased risk of cardiovascular disease. While prematurity is typically associated with ex utero neonatal growth restriction (GR), the independent effect of neonatal GR on c…

Cardiac Outcomes After Perinatal Sertraline Exposure in Mice Open

Sarah E. Haskell, Cecilia Lo, Mitchell E. Kent, Timothy M. Eggleston, Kenneth A. Volk , et al. · 2017

Selective serotonin reuptake inhibitors are prescribed to 6%–10% of pregnant women in the United States. Using an intrauterine plus neonatal exposure model to represent exposure throughout human pregnancy, we hypothesized sertraline exposu…

Perinatal SSRI exposure permanently alters cerebral serotonin receptor mRNA in mice but does not impact adult behaviors Open

Lauritz R. Meyer, Benjamin Dexter, Cecilia Lo, Elizabeth J. Kenkel, Takahito Hirai , et al. · 2017

Although no behavioral phenotype was observed, SSRI exposure in the perinatal period permanently alters cerebral receptor mRNA levels. We speculate these shifts in mRNA expression provide important compensation during SSRI exposure. Furthe…

Oral oestrogen reverses ovariectomy-induced morning surge hypertension in growth-restricted mice Open

Sarah E. Haskell, Veronica A. Peotta, Benjamin E. Reinking, Catherine Zhang, Vivian Zhu , et al. · 2016

Perinatal growth restriction (GR) is associated with heightened sympathetic tone and hypertension. We have previously shown that naturally occurring neonatal GR programmes hypertension in male but not female mice. We therefore hypothesized…

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