Keir Lewis
YOU?
Author Swipe
View article: NEW INC Y11 Creative Science: Inspirit: A Multisensory Experience for Enhancing Interoception and Reducing Anxiety
NEW INC Y11 Creative Science: Inspirit: A Multisensory Experience for Enhancing Interoception and Reducing Anxiety Open
Neuroaesthetics, the cognitive neuroscience of aesthetic experience, has revealed the profound impact of art, culture and technology on health. A growing body of evidence highlights the health benefits of sensory interventions across clini…
View article: A digital, self-management behaviour change intervention for people with Chronic Obstructive Pulmonary Disease: Cohort study (Preprint)
A digital, self-management behaviour change intervention for people with Chronic Obstructive Pulmonary Disease: Cohort study (Preprint) Open
BACKGROUND People with Chronic Obstructive Pulmonary Disease (pwCOPD) experience a range of limitations, which have a significant effect on their health. Self-management and pulmonary rehabilitation (PR) are key treatments for pwCOPD, how…
View article: A digital, self-management behaviour change intervention for people with Chronic Obstructive Pulmonary Disease: Cohort study (Preprint)
A digital, self-management behaviour change intervention for people with Chronic Obstructive Pulmonary Disease: Cohort study (Preprint) Open
PM may be a useful treatment to support COPD self-management, especially when barriers prevent people with COPD receiving traditional services such as PR. The quantitative results suggest that PM may be less beneficial when delivered along…
View article: Calcium-Sensing Receptor as a Novel Target for the Treatment of Idiopathic Pulmonary Fibrosis
Calcium-Sensing Receptor as a Novel Target for the Treatment of Idiopathic Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and no curative therapies. Fibroblast activation by transforming growth factor β1 (TGFβ1) and disrupted metabolic pathways, including the arginine–polyamine pathway, pl…
View article: What Does Randomization Do?
What Does Randomization Do? Open
In the health and social sciences, when it comes to causal inference, randomized controlled trials (RCTs) are considered the gold standard. The justification for granting RCTs this status is the claim that random allocation to different tr…
View article: Lower Airway and Oral Microbiome Dysbiosis in Patients with Long COVID Post-Hospitalisation: A UK Multicentre, Prospective Cohort Study
Lower Airway and Oral Microbiome Dysbiosis in Patients with Long COVID Post-Hospitalisation: A UK Multicentre, Prospective Cohort Study Open
View article: Quitting smoking and two-year survival after a diagnosis of small cell lung cancer
Quitting smoking and two-year survival after a diagnosis of small cell lung cancer Open
View article: Artificial neural network risk prediction of COPD exacerbations using urine biomarkers
Artificial neural network risk prediction of COPD exacerbations using urine biomarkers Open
Background COPD exacerbations cause considerable morbidity and mortality. We sought to identify a panel of urine biomarkers that can distinguish between stable and exacerbation states and predict risk of future exacerbations. Methods A ret…
View article: Microbiome diversity, intra-mucosal bacteria and immune integration within normal and asthmatic airway mucosa
Microbiome diversity, intra-mucosal bacteria and immune integration within normal and asthmatic airway mucosa Open
Asthma is characterized by reduced bronchial bacterial diversity and airway mucosal disruption. We examined spatial distributions of microbial sequences and host mucosal transcripts in bronchial biopsies from healthy controls and adult ast…
View article: 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study
1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study Open
Background In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid ad…
View article: Singing for lung health in COPD: a multicentre randomised controlled trial of online delivery
Singing for lung health in COPD: a multicentre randomised controlled trial of online delivery Open
Background Singing for lung health (SLH) is an arts-based breathing control and movement intervention for people with long-term respiratory conditions, intended to improve symptoms and quality of life. Online, remotely delivered programmes…
View article: Building a conceptual model on surgical preparedness
Building a conceptual model on surgical preparedness Open
View article: Genomic attributes of airway commensal bacteria and mucosa
Genomic attributes of airway commensal bacteria and mucosa Open
View article: COVID-19 managed on respiratory wards and intensive care units: Results from the national COVID-19 outcome report in Wales from March 2020 to December 2021
COVID-19 managed on respiratory wards and intensive care units: Results from the national COVID-19 outcome report in Wales from March 2020 to December 2021 Open
Background A COVID-19 hospital guideline was implemented across all 18 acute hospitals in Wales in March 2020, promoting ward management of COVID pneumonitis and data collected across the first 3 Waves of the pandemic (Wave 1 March 1 st 20…
View article: Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study Open
The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged.PHOSP-COVID was established to investigate the medium- and long-term…
View article: Towards a Personal Health Knowledge Graph Framework for Patient Monitoring
Towards a Personal Health Knowledge Graph Framework for Patient Monitoring Open
Healthcare providers face significant challenges with monitoring and managing patient data outside of clinics, particularly with insufficient resources and limited feedback on their patients' conditions. Effective management of these sympt…
View article: One year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study
One year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study Open
Background In patients with COVID-19 requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during acute C…
View article: P236 Adherence to home telemonitoring for COPD with digital coaching
P236 Adherence to home telemonitoring for COPD with digital coaching Open
Background Telemonitoring (TM) for COPD has been shown to reduce hospital admissions in some but not all studies and its cost-effectiveness has been questioned. However, technical advances, real-time coaching as well as increased digital e…
View article: S56 A feasibility randomised control trial (RCT) of OPEP verses active cycle of breathing technique (ACBT) in people with chronic obstructive pulmonary disease (COPD)
S56 A feasibility randomised control trial (RCT) of OPEP verses active cycle of breathing technique (ACBT) in people with chronic obstructive pulmonary disease (COPD) Open
NICE guideline NG115 for COPD recommend Airways Clearance Techniques (ACTs) for people with excessive sputum but there have been no studies comparing different ACTs. Aim To compare Oscillatory Positive Expiratory Pressure (OPEP, Aerobika<…
View article: Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study Open
View article: Heterogeneous Treatment Effects after Inspiratory Muscle Training during Recovery from Postacute COVID-19 Syndrome
Heterogeneous Treatment Effects after Inspiratory Muscle Training during Recovery from Postacute COVID-19 Syndrome Open
Purpose The objective of this study is to investigate whether heterogeneous treatment effects occur for changes in inspiratory muscle strength, perceived dyspnea, and health-related quality of life after 8 wk of unsupervised home-based ins…
View article: Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)
Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID) Open
PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged. PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring h…
View article: Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study Open
View article: The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer
The Economic Potential of Smoking Cessation Interventions at the Point of Diagnosis of Non–Small Cell Lung Cancer Open
This exploratory analysis indicates that SC intervention for smokers with patients with newly diagnosed NSCLC should be a cost-effective use of UK National Health Service resources. Additional research with focused costing is needed to con…
View article: The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study
The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study Open
Background Sleep disturbance is common following hospitalisation both for COVID-19 and other causes. The clinical associations are poorly understood, despite it altering pathophysiology in other scenarios. We, therefore, investigated wheth…
View article: The Chronic Obstructive Pulmonary Disease, COPD Optimisation ProjEct (COPE)
The Chronic Obstructive Pulmonary Disease, COPD Optimisation ProjEct (COPE) Open
The International Journal of Integrated Care (IJIC) is an online, open-access, peer-reviewed scientific journal that publishes original articles in the field of integrated care on a continuous basis.IJIC has an Impact Factor of 2.913 (2021…
View article: Perceptions of inspiratory muscle training in adults recovering from COVID-19
Perceptions of inspiratory muscle training in adults recovering from COVID-19 Open
Post COVID-19 condition can occur following infection with SARS-CoV-2 and is characterised by persistent symptoms, including fatigue, breathlessness and cognitive dysfunction, impacting everyday functioning. This study explored how people …
View article: Genomic and ecologic characteristics of the airway microbial-mucosal complex
Genomic and ecologic characteristics of the airway microbial-mucosal complex Open
S ummary paragraph Lung diseases due to infection and dysbiosis affect hundreds of millions of people world-wide 1-4 . Microbial communities at the airway mucosal barrier are conserved and highly ordered 5 , reflecting symbiosis and co-evo…
View article: Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study Open
View article: Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial
Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial Open
Background Many people recovering from coronavirus disease 2019 (COVID-19) experience prolonged symptoms, particularly breathlessness. We urgently need to identify safe and effective COVID-19 rehabilitative strategies. The aim of the curre…