Sarah E. Zanders
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View article: Impacts of stress and aging on spore health in <i>Schizosaccharomyces pombe</i>
Impacts of stress and aging on spore health in <i>Schizosaccharomyces pombe</i> Open
Most fungi can produce dormant, long-lived cells known as spores (e.g., conidia and ascospores). Spores play a critical role in fungal biology and human health, but much about spores is unknown. Here, we investigate factors affecting spore…
View article: Impacts of stress and aging on spore health in <i>Schizosaccharomyces pombe</i>
Impacts of stress and aging on spore health in <i>Schizosaccharomyces pombe</i> Open
Most fungi can produce dormant, long-lived cells known as spores. Spores play a critical role in fungal biology and human health, but much about spores is unknown. Here, we investigate factors affecting spore fitness using the fission yeas…
View article: Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans
Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans Open
Fungi can cause devastating invasive infections, typically in immunocompromised patients. Treatment is complicated both by the evolutionary similarity between humans and fungi and by the frequent emergence of drug resistance. Studies in fu…
View article: Functional constraints of wtf killer meiotic drivers
Functional constraints of wtf killer meiotic drivers Open
Killer meiotic drivers are selfish DNA loci that sabotage the gametes that do not inherit them from a driver+/driver− heterozygote. These drivers often employ toxic proteins that target essential cellular functions to cause the destruction…
View article: Functional constraints of <i>wtf</i> killer meiotic drivers
Functional constraints of <i>wtf</i> killer meiotic drivers Open
Killer meiotic drivers are selfish DNA loci that sabotage the gametes that do not inherit them from a driver+/driver- heterozygote. These drivers often employ toxic proteins that target essential cellular functions to cause the destruction…
View article: Saturation transposon mutagenesis enables genome-wide identification of genes required for growth and fluconazole resistance in the human fungal pathogen<i>Cryptococcus neoformans</i>
Saturation transposon mutagenesis enables genome-wide identification of genes required for growth and fluconazole resistance in the human fungal pathogen<i>Cryptococcus neoformans</i> Open
Fungi can cause devastating invasive infections, typically in immunocompromised patients. Treatment is complicated both by the evolutionary similarity between humans and fungi and by the frequent emergence of drug resistance. Studies in fu…
View article: Modeling the evolution of <i>Schizosaccharomyces pombe</i> populations with multiple killer meiotic drivers
Modeling the evolution of <i>Schizosaccharomyces pombe</i> populations with multiple killer meiotic drivers Open
Meiotic drivers are selfish genetic loci that can be transmitted to more than half of the viable gametes produced by a heterozygote. This biased transmission gives meiotic drivers an evolutionary advantage that can allow them to spread ove…
View article: Modeling the Evolution of Populations with Multiple Killer Meiotic Drivers
Modeling the Evolution of Populations with Multiple Killer Meiotic Drivers Open
Meiotic drivers are selfish genetic loci that can be transmitted to more than half of the viable gametes produced by a heterozygote. This biased transmission gives meiotic drivers an evolutionary advantage that can allow them to spread ove…
View article: S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive
S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive Open
Meiotic drivers bias gametogenesis to ensure their transmission into more than half the offspring of a heterozygote. In Schizosaccharomyces pombe , wtf meiotic drivers destroy the meiotic products (spores) that do not inherit the driver fr…
View article: Genome-wide quantification of contributions to sexual fitness identifies genes required for spore viability and health in fission yeast
Genome-wide quantification of contributions to sexual fitness identifies genes required for spore viability and health in fission yeast Open
Numerous genes required for sexual reproduction remain to be identified even in simple model species like Schizosaccharomyces pombe . To address this, we developed an assay in S . pomb e that couples transposon mutagenesis with high-throug…
View article: The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years
The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years Open
Meiotic drivers are selfish elements that bias their own transmission into more than half of the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought to exist for relatively short evolutionary timespans be…
View article: What can we learn from selfish loci that break Mendel’s law?
What can we learn from selfish loci that break Mendel’s law? Open
Exceptions to Mendel's law of segregation were important for demonstrating that chromosomes carry genetic material. Scrutiny of additional exceptions to Mendel's law caused by selfish genes has the potential to unravel other unsolved myste…
View article: The <i>wtf</i> meiotic driver gene family has unexpectedly persisted for over 100 million years
The <i>wtf</i> meiotic driver gene family has unexpectedly persisted for over 100 million years Open
Meiotic drivers are selfish elements that bias their own transmission into more than half of the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought to exist for relatively short evolutionary timespans be…
View article: Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe
Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe Open
Meiotic drivers are genetic elements that break Mendel’s law of segregation to be transmitted into more than half of the offspring produced by a heterozygote. The success of a driver relies on outcrossing (mating between individuals from d…
View article: Molecular Mechanisms and Evolutionary Consequences of Spore Killers in Ascomycetes
Molecular Mechanisms and Evolutionary Consequences of Spore Killers in Ascomycetes Open
In this review, we examine the fungal spore killers. These are meiotic drive elements that cheat during sexual reproduction to increase their transmission into the next generation.
View article: Author response: Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe
Author response: Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Meiotic d…
View article: <i>S. pombe wtf</i> genes use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive
<i>S. pombe wtf</i> genes use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive Open
Meiotic drivers bias gametogenesis to ensure their transmission into more than half the offspring of a heterozygote. In Schizosaccharomyces pombe , wtf meiotic drivers destroy the meiotic products (spores) that do not inherit the driver fr…
View article: Genome-wide identification of sexual-reproduction genes in fission yeast via transposon-insertion sequencing
Genome-wide identification of sexual-reproduction genes in fission yeast via transposon-insertion sequencing Open
Many genes required for sexual reproduction remain to be identified. Moreover, many of the genes that are known have been characterized in distinct experiments using different conditions, which complicates understanding the relative contri…
View article: Diverse mating phenotypes impact the spread of <i>wtf</i> meiotic drivers in <i>S. pombe</i>
Diverse mating phenotypes impact the spread of <i>wtf</i> meiotic drivers in <i>S. pombe</i> Open
Meiotic drivers are genetic loci that break Mendel’s law of segregation to be transmitted into more than half of the offspring produced by a heterozygote. The success of a driver relies on outcrossing because drivers gain their advantage i…
View article: The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death
The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death Open
Meiotic drivers are parasitic loci that force their own transmission into greater than half of the offspring of a heterozygote. Many drivers have been identified, but their molecular mechanisms are largely unknown. The wtf4 gene is a meiot…
View article: Author response: The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death
Author response: The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Meiotic drivers are parasitic…
View article: Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers
Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers Open
Killer meiotic drivers are genetic parasites that destroy ‘sibling’ gametes lacking the driver allele. The fitness costs of drive can lead to selection of unlinked suppressors. This suppression could involve evolutionary tradeoffs that com…
View article: Author response: Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers
Author response: Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Killer meiotic drivers are gene…
View article: Atypical meiosis can be adaptive in outcrossed<i>S. pombe</i>due to<i>wtf</i>meiotic drivers
Atypical meiosis can be adaptive in outcrossed<i>S. pombe</i>due to<i>wtf</i>meiotic drivers Open
Killer meiotic drivers are genetic parasites that destroy ‘sibling’ gametes lacking the driver allele. The fitness costs of drive can lead to selection of unlinked suppressors. This suppression could involve evolutionary tradeoffs that com…
View article: The<i>wtf4</i>meiotic driver utilizes controlled protein aggregation to generate selective cell death
The<i>wtf4</i>meiotic driver utilizes controlled protein aggregation to generate selective cell death Open
Meiotic drivers are parasitic loci that force their own transmission into greater than half of the offspring of a heterozygote. Many drivers have been identified, but their molecular mechanisms are largely unknown. The wtf4 gene is a meiot…
Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency Open
Meiotic drivers are selfish alleles that can force their transmission into more than 50% of the viable gametes made by heterozygotes. Meiotic drivers are known to cause infertility in a diverse range of eukaryotes and are predicted to affe…
View article: Dramatically diverse<i>S. pombe wtf</i>meiotic drivers all display high gamete-killing efficiency
Dramatically diverse<i>S. pombe wtf</i>meiotic drivers all display high gamete-killing efficiency Open
Meiotic drivers are selfish genetic loci that force their transmission into more than 50% of the viable gametes made by heterozygotes. Meiotic drivers are known to cause infertility in a diverse range of eukaryotes and are predicted to aff…