Explanipedia

Mental Health Outcomes Among Homeschooled and Traditionally Schooled Adolescents in Egypt (Ages 12–18): A Cross-Sectional Study Open

Abdulkarim Hasan, Ahmed Ismael, Mohamed A. Zayed, Mahmoud M Abdelwahed, Ahmed Abdelwahed , et al. · 2025

Female adolescents exhibited significantly higher levels of depression, anxiety, and stress compared to males, while the educational setting was not found to be significantly associated with mental health outcomes. Future studies with larg…

Endothelial CEPT1 Regulates Hepatic MTTP-Mediated Lipid Metabolism and Impacts Aortic Atherosclerosis Open

Mohamed A. Zayed, Dina Ibrahim, Shahab Hafezi, Tariq Jamal Khan, Ibrahim Kuziez , et al. · 2025

Background The regulation of hepatic lipid metabolism by vascular endothelial factors remains poorly characterized, despite its relevance to atherosclerosis and steatosis. Microsomal triglyceride transfer protein (MTTP) is essential for he…

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis Open

Xuejing Liu, Anyuan He, Dongliang Lu, Donghua Hu, Min Tan , et al. · 2025

Protocol for dorsal ovariectomy and elastase-induced abdominal aortic aneurysm in rats Open

Mohamed Zaghloul, Santiago Elizondo-Benedetto, Louai Alrata, Dina Ibrahim, Nicholas Speller , et al. · 2025

Novel Papain-Elastase Induced Murine Model for Infrarenal Abdominal Aortic Aneurysm Rupture Open

Mohamed A. Zayed, Santiago Elizondo Benedetto, Batool Arif, Mohamed S. Zaghloul, Ibrahim Kuziez · 2025

Abdominal aortic aneurysm (AAA) rupture leads to high morbidity and mortality. Current rodent models struggle to reliably mimic infrarenal AAA rupture. Chemical treatments using porcine pancreatic elastase (PPE), papain (Pap), β-aminopropi…

Large animal model validation of a fenestrated balloon-expandable stent for treatment of aortoiliac occlusive disease Open

Sophia R. Pyeatte, Maxwell C. Braasch, John Cashin, Mohamed Zaghloul, Santiago Elizondo Benedetto , et al. · 2025

C-C Chemokine Receptor 2 is a Tissue Biomarker for Abdominal Aortic Aneurysmal and Occlusive Disease Open

Shahab Hafezi, Batool Arif, Rajrani Ruhel, Mohamed Zaghloul, Santiago Elizondo-Benedetto , et al. · 2025

Objective: This study evaluated whether C-C Chemokine Receptor 2 (CCR2) is a tissue biomarker of aortic disease severity, particularly in patients with abdominal aortic aneurysm (AAA). Background: There is an unmet clinical need for tissue…

Engineering Adhesive Hydrogels for Hemostasis and Vascular Repair Open

Juya Jeon, Shri Venkatesh Subramani, Kok Zhi Lee, Santiago Elizondo Benedetto, Mohamed A. Zayed , et al. · 2025

Adhesive hydrogels with tunable mechanical properties and strong adhesion to wet, dynamic tissues have emerged as promising materials for tissue repair, with potential applications in wound closure, hemorrhage control, and surgical adhesiv…

Dynamic Rigidity Control for Supportive Sheaths in Endovascular Procedures Open

Michael Qiu, Vinay Chandrasekaran, Chase M. Hartquist, Halle Lowe, Charles Suskin , et al. · 2025

Endovascular procedures require sheaths with contradictory mechanical properties: flexibility for navigation through tortuous vessels, yet rigidity for device delivery. Current approaches rely on multiple device exchanges, increasing proce…

Endothelial Cept1 Promotes Post-Ischemic Angiogenesis in a Pparα-Dependent Fashion Open

Tariq Khan, Rodrigo Meade, Santiago Elizondo Benedetto, Larisa Belaygorod, Omar Saffaf , et al. · 2025

Background Cept1 is essential for de novo phopholipogenesis and is impacted by diabetes. We previously demonstrated that conditional knockdown of Cept1 in the endothelium leads to reduced hindlimb angiogenesis and tissue recovery. We hypot…

Sauna use as a novel management approach for cardiovascular health and peripheral arterial disease Open

Sergio Sastriques-Dunlop, Santiago Elizondo-Benedetto, Mohamed A. Zayed · 2025

Introduction Heat therapy (HT), particularly in the form of whole-body sauna bathing, has emerged as a promising intervention for the management of cardiovascular disease (CVD). Passive HT can induce both local and systemic physiological r…

Targeting fatty acid synthase reduces aortic atherosclerosis and inflammation Open

Rodrigo Meade, Dina Ibrahim, Connor Engel, Larisa Belaygorod, Batool Arif , et al. · 2025

Fatty acid synthase (FAS) is predominantly expressed in the liver and adipose tissue. It plays vital roles in de novo synthesis of saturated fatty acids and regulates insulin sensitivity. We previously demonstrated that serum circulating F…

Structured query language tool to identify untreated individuals with abdominal aortic aneurysms Open

Jenna Brambora, Sophia Roberts, Kanhua Yin, Ikenna Okereke, Zachary J. Wanken , et al. · 2024

Targeting Fatty Acid Synthase Reduces Aortic Atherosclerosis and Inflammation Open

Mohamed A. Zayed, Rodrigo Meade, Connor Engel, Larisa Belaygorod, Batool Arif , et al. · 2024

Fatty acid synthase (FAS) is predominantly expressed in the liver and adipose tissue. It plays vital roles in de novo synthesis of saturated fatty acid and regulates insulin sensitivity. We previously demonstrated that serum circulating FA…

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial Open

Peter Sandercock, Janet Darbyshire, David L. DeMets, Robert Fowler, David G. Lalloo , et al. · 2024

Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial Open

Saul N. Faust, Richard Haynes, Christine E. Jones, Natalie Staplin, Elizabeth Whittaker , et al. · 2024

Medical Research Council and National Institute of Health Research.

Ketosis prevents abdominal aortic aneurysm rupture through C–C chemokine receptor type 2 downregulation and enhanced extracellular matrix balance Open

Sergio Sastriques-Dunlop, Santiago Elizondo-Benedetto, Batool Arif, Rodrigo Meade, Mohamed S. Zaghloul , et al. · 2024

Abdominal aortic aneurysms (AAAs) are prevalent with aging, and AAA rupture is associated with increased mortality. There is currently no effective medical therapy to prevent AAA rupture. The monocyte chemoattractant protein (MCP-1)/C–C ch…

Endothelial CEPT1 Impacts Aortic Atherosclerosis and Hepatic Lipoprotein Metabolism Open

Shahab Hafezi, Tariq Khan, Larisa Belaygorod, Batool Arif, Clay F. Semenkovich , et al. · 2024

Structured query language tool to identify untreated individuals with abdominal aortic aneurysms Open

Jenna Brambora, Sophia Roberts, Kanhua Yin, Ifeanyichukwu Okereke, Zachary J. Wanken , et al. · 2024

ObjectiveDespite well-established guidelines for the diagnosis and surveillance of abdominal aortic aneurysms (AAAs), many patients are still not discovered until they have already sustained a rupture. It is estimated that as many as 50% o…

Peripheral Phosphocreatine Assessment with Dynamic 1H MRI Open

Ryan Wahidi, Ran Li, Mohamed A. Zayed, Mary K. Hastings, Clay F. Semenkovich , et al. · 2024

Genetically Engineered Protein-Based Bioadhesives with Programmable Material Properties Open

Juya Jeon, Kok Zhi Lee, Xiaolu Zhang, John Jaeger, Eugene Kim , et al. · 2023

Silk-amyloid-mussel foot protein (SAM) hydrogels made from recombinant fusion proteins containing β-amyloid peptide, spider silk domain, and mussel foot protein (Mfp) are attractive bioadhesives as they display a unique combination of tuna…

Chemokine Receptor 2 Is A Theranostic Biomarker for Abdominal Aortic Aneurysms Open

Santiago Elizondo-Benedetto, Sergio Sastriques-Dunlop, Lisa Detering, Batool Arif, Gyu Seong Heo , et al. · 2023

Abdominal aortic aneurysm (AAA) is a degenerative vascular disease impacting aging populations with a high mortality upon rupture. There are no effective medical therapies to prevent AAA expansion and rupture. We previously demonstrated th…

Quantitative Assessment of Peripheral Oxidative Metabolism With a New Dynamic 1H MRI Technique: A Pilot Study in People With and Without Diabetes Mellitus Open

Ryan Wahidi, Yi Zhang, Ran Li, Jiadi Xu, Mohamed A. Zayed , et al. · 2023

Background Type 2 diabetes mellitus (T2DM) is linked to impaired mitochondrial function. Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is a gadolinium‐contrast‐free 1 H method to assess mitochondrial functio…

Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing Open

Hong Niu, Ya Guan, Ting Zhong, Liang Ma, Mohamed A. Zayed , et al. · 2023

Various therapies have been utilized for treating diabetic wounds, yet current regiments do not simultaneously address the key intrinsic causes of slow wound healing, i.e., abnormal skin cell functions (particularly migration), delayed ang…

Ketosis Prevents Abdominal Aortic Aneurysm Rupture Through C-C Chemokine Receptor Type 2 Downregulation and Enhanced MMP Balance Open

Mohamed A. Zayed, Sergio Sastriques-Dunlop, Santiago Elizondo-Benedetto, Batool Arif, Rodrigo Meade , et al. · 2023

Abdominal aortic aneurysms (AAAs) are prevelant with aging, and AAA rupture is associated with high mortality. There is currently no effective medical therapy for AAA rupture. Previous work demonstrated that the monocyte chemoattractant pr…

Carotid atherosclerotic plaque segmentation in multi-weighted MRI using a two-stage neural network: advantages of training with high-resolution imaging and histology Open

Ran Li, Jie Zheng, Mohamed A. Zayed, Jeffrey E. Saffitz, Pamela K. Woodard , et al. · 2023

Introduction A reliable and automated method to segment and classify carotid artery atherosclerotic plaque components is needed to efficiently analyze multi-weighted magnetic resonance (MR) images to allow their integration into patient ri…

Structured Query Language Tool to Identify Untreated Patients With Abdominal Aortic Aneurysms and Other Vascular Diseases Open

Jenna Brambora, Sophia Roberts, Ifeanyichukwu Okereke, Zachary J. Wanken, Nathan Droz , et al. · 2023

Modified bare-back micro-retrograde tibial arterial access to facilitate peripheral endovascular therapy Open

Faiz Gani, Momodou L. Jammeh, Mohamed A. Zayed · 2023

KIDNEY AFFECTION AMONG WORKERS EXPOSED TO SILICA IN AN IRON AND STEEL FOUNDRY Open

Mona Hussein, Iman Attia, Mohamed A. Zayed, A. Rashed, Ghada Hossam El-Din El-Sherif · 2023

Introduction: Silica is used in many industries such as foundries, glass production, cement, concrete, ceramic, porcelain, pottery, bricks, sandblasting, abrasives and construction activities.Several studies have linked long term silica ex…

Ketosis Prevents Abdominal Aortic Aneurysm Rupture Through CCR2 Downregulation and Enhanced MMP Balance Open

Sergio Sastriques-Dunlop, Santiago Elizondo-Benedetto, Batool Arif, Rodrigo Meade, Mohamed S. Zaghloul , et al. · 2023

Abdominal aortic aneurysms (AAAs) are common in aging populations, and AAA rupture is associated with high morbidity and mortality. There is currently no effective medical preventative therapy for AAAs to avoid rupture. It is known that th…

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