Sarah Eversden
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View article: [P4–102]: CHARACTERISATION OF MOLECULAR MECHANISMS THAT ARE TRIGGERED AND CONTRIBUTE TO TAU PATHOLOGY IN A CELL MODEL OF TAU AGGREGATION
[P4–102]: CHARACTERISATION OF MOLECULAR MECHANISMS THAT ARE TRIGGERED AND CONTRIBUTE TO TAU PATHOLOGY IN A CELL MODEL OF TAU AGGREGATION Open
Aggregation of tau is the characteristic feature of all human tauopathies. It is known that in Alzheimer's disease (AD) several cellular mechanisms can be triggered and drive tau conformational alterations, aggregation and propagation. Her…
View article: Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation
Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation Open
Intracellular neurofibrillary tangles (NFTs) are the hallmark of Alzheimer’s disease and other tauopathies in which tau, a microtubule-associated protein, loses its ability to stabilize microtubules. Several post-translational modification…