Sarah E. Ferguson
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View article: Impact of FIGO 2023 staging criteria on stage migration and survival outcomes in early-stage endometrial cancer: A retrospective cohort study
Impact of FIGO 2023 staging criteria on stage migration and survival outcomes in early-stage endometrial cancer: A retrospective cohort study Open
The FIGO 2023 EC staging revision has resulted in significant upstaging from IA/IB to II, due to incorporation of lymphovascular space invasion, histology, and molecular profiles. No significant differences in survival were found between F…
View article: Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel
Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel Open
Genetic testing in epithelial ovarian cancer (EOC) in Ontario includes germline next‐generation sequencing (NGS) for 19 genes. Additionally, tumor tissue undergoes reflex NGS testing for BRCA1/2 to assess eligibility for PARPi. Although pa…
View article: Adrenal insufficiency after megestrol acetate for fertility-sparing treatment of endometrial cancer
Adrenal insufficiency after megestrol acetate for fertility-sparing treatment of endometrial cancer Open
•AI is a rare yet potentially life-threatening side effect of MA when used for fertility sparing for EC/AH.•The presentation of AI is highly variable and clinicians should employ a low threshold for investigations.•AI can occur while on MA…
View article: Clinical outcomes of neuroendocrine carcinoma of the cervix: Retrospective review from a large academic cancer centre
Clinical outcomes of neuroendocrine carcinoma of the cervix: Retrospective review from a large academic cancer centre Open
In our single institution review of neuroendocrine carcinoma of the cervix, primary surgery was associated with improved OS; however, our sample size was small with a bias to offering upfront surgery to patients with earlier stage disease.
View article: Surgical approach, preoperative LEEP/conization and patterns of recurrence and death in low-risk cervical cancer – exploratory analysis from the CCTG CX.5/SHAPE trial
Surgical approach, preoperative LEEP/conization and patterns of recurrence and death in low-risk cervical cancer – exploratory analysis from the CCTG CX.5/SHAPE trial Open
Background: SHAPE demonstrated that simple hysterectomy was not inferior to radical hysterectomy in patients with low-risk cervical cancer. To further understand the role of preoperative LEEP/conization, clear LEEP/conization margins and s…
View article: Supplementary Table S2 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S2 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Antibodies and materials.
View article: Supplementary Figure S7 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S7 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S7. Intratumoural CD103+CD56+Lin- ILCs displayed unique profile of transcription factors.
View article: Supplementary Figure S8 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S8 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S8. CD56+ ILCs cluster 0 from CITE-seq are composed of predominately CD103+CD49a+ expressing cells.
View article: Supplementary Figure S9 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S9 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S9. CD103+CD56+Lin- ILCs express distinct signatures compared to other ILC subsets.
View article: Supplementary Figure S5 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S5 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S5. Identifying cellular clusters from scRNA-seq of ovarian tumours.
View article: Supplementary Table S8 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S8 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
DEGs of CD8+ T cells from tumours with a high proportion, compared to a low proportion, of CD103+CD56+ ILCs.
View article: Supplementary Figure S10 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S10 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S10. CD103+Lin- ILC1-like cells are associated with altered immune landscape within the TME.
View article: Supplementary Table S1 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S1 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Patient characteristics.
View article: Data from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Data from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling the complex network of immune cells within the tumor microenvironment (TME) may provide additional in…
View article: Supplementary Table 6 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table 6 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
DEGs that characterized cell clusters from scRNA-seq and CITE-seq datasets.
View article: Supplementary Table S3 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S3 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Differentially expressed genes of intratumoural CD103+CD56+ ILCs compared to CD103-CD56+ NK cells from HGSC tumours using bulk-RNAseq.
View article: Supplementary Table 7 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table 7 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Transcription factor regulons that were enriched in CD103+CD56+ ILCs from scRNA-seq.
View article: Supplementary Figure S6 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S6 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S6. CD103+CD56+ ILCs have distinct transcriptional networks revealed by SCENIC analysis.
View article: Supplementary Figure S4 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S4 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig S4. CD101 and GITR expression is expressed on CD103+CD49a+CD56+Lin- ILCs but not other NK cell subsets.
View article: Supplementary Table S4 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S4 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
List of gene sets enriched in CD103+CD56+ ILCs from GSEA using bulk-RNAseq.
View article: Supplementary Figure S2 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S2 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S2. CD103+CD56+Lin- ILCs express distinct gene expression compared to CD103-CD56+Lin-ILCs.
View article: Supplementary Table S5 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S5 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Proportion of cells per clusters for each patient sample from scRNA-seq and CITE-seq datasets.
View article: Supplementary Figure S1 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S1 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S1. Gating strategy for intratumoural ILCs.
View article: Supplementary Figure S3 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S3 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S3. CD103+CD56+Lin- ILCs exhibit features that are associated with Tregs.
View article: Canadian consensus for the assessment and testing of Lynch syndrome
Canadian consensus for the assessment and testing of Lynch syndrome Open
Background Lynch syndrome (LS) is an autosomal dominant cancer predisposition syndrome caused by a germline pathogenic variant, or epigenetic silencing, of a mismatch repair (MMR) gene, leading to a wide cancer spectrum with gene-specific …
View article: Psychological impact of risk-reducing surgery for gynecologic cancer among women with Lynch syndrome
Psychological impact of risk-reducing surgery for gynecologic cancer among women with Lynch syndrome Open
HCPs should consider facilitators to surgery in women with LS contemplating RRS. HCPs should also provide women with LS more detailed post-surgery information on what to expect, and risks of other health conditions.
View article: CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment
CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open
Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling the complex network of immune cells within the tumor microenvironment (TME) may provide additional in…
View article: Eliminating Digestive Irregularities Caused by Late Effects: A Pilot Study of an Innovative Culinary Nutrition Intervention for Reducing Gastrointestinal Toxicity in Gynecologic Cancer Patients Who Have Undergone Pelvic Radiotherapy
Eliminating Digestive Irregularities Caused by Late Effects: A Pilot Study of an Innovative Culinary Nutrition Intervention for Reducing Gastrointestinal Toxicity in Gynecologic Cancer Patients Who Have Undergone Pelvic Radiotherapy Open
Background/Objectives: Pelvic radiotherapy (RT) improves survival in gynecologic cancer patients but often results in gastrointestinal (GI) toxicity, affecting quality of life. Standard nutrition guidance lacks specificity for these surviv…
View article: Gynecologic cancer screening among women with Lynch syndrome: Information and healthcare access needs
Gynecologic cancer screening among women with Lynch syndrome: Information and healthcare access needs Open
Psychoeducational interventions are important to manage uncertainty associated with LS, increasing social and informational support, and informing health care providers about best practices with this population.