Sarah Guimbal
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View article: Identifying a potential role of immune cells in gadolinium deposition within the brain
Identifying a potential role of immune cells in gadolinium deposition within the brain Open
Background Gadolinium (Gd) deposition in the brain was observed in patients with history of gadolinium-based contrast agent (GBCA) administration. However, the exact mechanism behind this deposition remains unclear, especially given that a…
View article: Thrombosis in the Coronary Microvasculature Impairs Cardiac Relaxation and Induces Diastolic Dysfunction
Thrombosis in the Coronary Microvasculature Impairs Cardiac Relaxation and Induces Diastolic Dysfunction Open
BACKGROUND: Heart failure with preserved ejection fraction is proposed to be caused by endothelial dysfunction in cardiac microvessels. Our goal was to identify molecular and cellular mechanisms underlying the development of cardiac microv…
View article: Thrombosis in the coronary microvasculature may be responsible for impaired cardiac relaxation and diastolic dysfunction
Thrombosis in the coronary microvasculature may be responsible for impaired cardiac relaxation and diastolic dysfunction Open
Introduction Heart Failure with Preserved Ejection Fraction (HFpEF) is proposed to be caused by endothelial dysfunction in cardiac small vessels. We previously identified Hhipl1,as a gene upregulated in the coronary vasculature of Leptin r…
View article: Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis
Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis Open
Blood–brain barrier (BBB) breakdown and immune cell infiltration into the CNS are early hallmarks of multiple sclerosis (MS). The mechanisms leading to BBB dysfunction are incompletely understood and generally thought to be a consequence o…
View article: Mast Cells Are the Trigger of Small Vessel Disease and Diastolic Dysfunction in Diabetic Obese Mice
Mast Cells Are the Trigger of Small Vessel Disease and Diastolic Dysfunction in Diabetic Obese Mice Open
Objective: Heart failure with preserved ejection fraction is a major health care issue which has been difficult to manage to date, due to its complex and not well understood pathophysiology. Specifically, if a wealth of literature focuses …
View article: Blood–brain barrier genetic disruption leads to protective barrier formation at the Glia Limitans
Blood–brain barrier genetic disruption leads to protective barrier formation at the Glia Limitans Open
Inflammation of the central nervous system (CNS) induces endothelial blood–brain barrier (BBB) opening as well as the formation of a tight junction barrier between reactive astrocytes at the Glia Limitans. We hypothesized that the CNS pare…
View article: Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes)
Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes) Open
Objective: Evidences accumulated within the past decades identified hedgehog signaling as a new regulator of endothelium integrity. More specifically, we recently identified Dhh (desert hedgehog) as a downstream effector of Klf2 (Kruppel-l…
View article: Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability
Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability Open
Aims The therapeutic potential of Hedgehog (Hh) signalling agonists for vascular diseases is of growing interest. However, molecular and cellular mechanisms underlying the role of the Hh signalling in vascular biology remain poorly underst…
View article: Mast cells participate in the development of diastolic dysfunction in diabetic obese mice
Mast cells participate in the development of diastolic dysfunction in diabetic obese mice Open
Rational Heart failure with preserved ejection fraction (HFpEF) is a growing epidemiologic issue. However, to date, its pathophysiology remains poorly understood. Objective Our goal was to investigate the role of microvessel disease in the…
View article: Desert Hedgehog-driven endothelium integrity is enhanced by Gas1 but negatively regulated by Cdon
Desert Hedgehog-driven endothelium integrity is enhanced by Gas1 but negatively regulated by Cdon Open
Evidences accumulated within the past decades, identified Hedgehog (Hh) signaling as a new regulator of micro-vessel integrity. More specifically, we recently identified Desert Hedgehog (Dhh) as a downstream effector of Klf2 in endothelial…
View article: Genetic disruption of the Blood Brain Barrier leads to protective barrier formation at the Glia Limitans
Genetic disruption of the Blood Brain Barrier leads to protective barrier formation at the Glia Limitans Open
Recent work demonstrated that Central Nervous System (CNS) inflammation induces endothelial Blood Brain Barrier (BBB) opening as well as the formation of a tight junction barrier between reactive astrocytes at the Glia Limitans. We hypothe…
View article: Endothelial cell response to Hedgehog ligands depends on their processing
Endothelial cell response to Hedgehog ligands depends on their processing Open
Rationale The therapeutic potential of Hedgehog (Hh) signaling agonists for vascular diseases is of growing interest. However, molecular and cellular mechanisms underlying the role of the Hh signaling in vascular biology remain poorly unde…
View article: Dock5 is a new regulator of microtubule dynamic instability in osteoclasts
Dock5 is a new regulator of microtubule dynamic instability in osteoclasts Open
Background Information Osteoclast resorption is dependent on a podosome‐rich structure called sealing zone. It tightly attaches the osteoclast to the bone creating a favourable acidic microenvironment for bone degradation. This adhesion st…
View article: Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance
Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance Open
The role of Hedgehog (Hh) signaling in vascular biology has first been highlighted in embryos by Pepicelli et al. in 1998 and Rowitch et al. in 1999. Since then, the proangiogenic role of the Hh ligands has been confirmed in adults, especi…
View article: Dock5 is a new regulator of microtubule dynamic instability through GSK3β inhibition in osteoclasts
Dock5 is a new regulator of microtubule dynamic instability through GSK3β inhibition in osteoclasts Open
Background information Osteoclast resorption is dependent on a podosome-rich structure, called sealing zone, which is stabilized by acetylated microtubules. It tightly attaches the osteoclast to the bone creating a favorable acidic microen…