Sarah Heintz
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View article: Protocol for isolating CD163+ Kupffer cells from human liver resections
Protocol for isolating CD163+ Kupffer cells from human liver resections Open
View article: TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism Open
Objective Achieving HBV cure will require novel combination therapies of direct-acting antivirals and immunomodulatory agents. In this context, the toll-like receptor 8 (TLR8) agonist selgantolimod (SLGN) has been investigated in preclinic…
View article: Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes
Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes Open
Our results propose that by binding to liver targeted lipoproteins and using the reverse cholesterol transport pathway of macrophages, HBV hijacks the physiological lipid transport pathways to the liver to most efficiently reach its target…
View article: New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome
New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome Open
Objective To pinpoint the earliest cellular defects underlying seizure onset (epileptogenic period) during perinatal brain development in a new zebrafish model of Dravet syndrome (DS) and to investigate potential disease‐modifying activity…