Sarah Hoedemakers
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View article: Effects of exercise on cardiac structure and function in patients with type 2 diabetes: a narrative review of prospective imaging studies
Effects of exercise on cardiac structure and function in patients with type 2 diabetes: a narrative review of prospective imaging studies Open
Around 30% of patients with type 2 diabetes(T2D) develop heart failure and this leads to poor prognosis. Treatment with exercise intervention can improve left cardiac function at rest in T2D, but its effects on subclinical HF markers, maxi…
View article: Does oxygen pulse represent a reliable surrogate for stroke volume during exercise? Insights from cardiopulmonary exercise test combined with echocardiography or invasive measurements
Does oxygen pulse represent a reliable surrogate for stroke volume during exercise? Insights from cardiopulmonary exercise test combined with echocardiography or invasive measurements Open
Background While interpreting the mechanisms underlying exercise limitation in cardiopulmonary exercise testing (CPET), oxygen pulse (O2pulse) is often assumed to be a surrogate for stroke volume (SV). However, in the rearranged Fick’s equ…
View article: Prognostic value of exercise right ventricular-pulmonary arterial coupling in primary mitral regurgitation
Prognostic value of exercise right ventricular-pulmonary arterial coupling in primary mitral regurgitation Open
Background Exercise-induced pulmonary hypertension (mPAP/CO slope >3mmHg/L/min) was recently associated with worse outcome in >moderate PMR. However, the prognostic value of right ventricle to pulmonary artery coupling (RVPAc) is unk…
View article: An elevated mPAP over CO slope by exercise echocardiography predicts outcome in unexplained dyspnea
An elevated mPAP over CO slope by exercise echocardiography predicts outcome in unexplained dyspnea Open
Background Exercise pulmonary hypertension, defined by a slope of mean pulmonary artery pressure (mPAP) over cardiac output (CO) >3 mmHg/L/min, measured by invasive exercise hemodynamics, is associated with worse event-free survival in …
View article: Clinical Significance of Exercise Pulmonary Hypertension With a Negative Diastolic Stress Test for Suspected Heart Failure With Preserved Ejection Fraction
Clinical Significance of Exercise Pulmonary Hypertension With a Negative Diastolic Stress Test for Suspected Heart Failure With Preserved Ejection Fraction Open
Background Half of patients with heart failure with preserved ejection fraction (HFpEF) remain undiagnosed by resting evaluation alone. Therefore, exercise testing is proposed. The diastolic stress test (DST), however, has limited sensitiv…
View article: The Oxygen Cascade According to HFpEF Likelihood
The Oxygen Cascade According to HFpEF Likelihood Open
View article: mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis
mPAP/CO Slope and Oxygen Uptake Add Prognostic Value in Aortic Stenosis Open
BACKGROUND: Recent guidelines redefined exercise pulmonary hypertension as a mean pulmonary artery pressure/cardiac output (mPAP/CO) slope >3 mm Hg·L −1 ·min −1 . A peak systolic pulmonary artery pressure >60 mm Hg during exercise has been…
View article: Cardiac dysfunction rather than aortic valve stenosis severity drives exercise intolerance and adverse haemodynamics
Cardiac dysfunction rather than aortic valve stenosis severity drives exercise intolerance and adverse haemodynamics Open
Aims To study the impact of heart failure with preserved ejection fraction (HFpEF) vs. aortic stenosis (AS) lesion severity on left ventricular (LV) hypertrophy, diastolic dysfunction, left atrial (LA) dysfunction, haemodynamics, and exerc…
View article: Cardiac dysfunction rather than aortic valve stenosis severity drives exercise intolerance and adverse hemodynamics
Cardiac dysfunction rather than aortic valve stenosis severity drives exercise intolerance and adverse hemodynamics Open
Funding Acknowledgements Type of funding sources: None. Background Aortic valve stenosis (AS) and heart failure with preserved ejection fraction (HFpEF) present with similar cardiac alterations, but their overlap is poorly understood.(1–3)…