Sarah Keedy
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View article: Hippocampal glutamate and verbal episodic memory in the psychosis spectrum: A preliminary report
Hippocampal glutamate and verbal episodic memory in the psychosis spectrum: A preliminary report Open
View article: The Frontal Lobe Outcomes and Well-being (FLOW) Study: Cannabis Effects on Neurocognition and HIV-related outcomes (Preprint)
The Frontal Lobe Outcomes and Well-being (FLOW) Study: Cannabis Effects on Neurocognition and HIV-related outcomes (Preprint) Open
BACKGROUND Heavy cannabis use may impact neurocognitive functions, particularly prefrontal and limbic systems responsible for risk/reward processing and executive function, which are essential for certain health behaviors, such as human i…
View article: Associations of social and genetic background variables to neuro-cognitive biomarkers of psychosis
Associations of social and genetic background variables to neuro-cognitive biomarkers of psychosis Open
Socioeconomic (SES) and ethno-racial factors may tilt psychosis diagnoses for persons from different backgrounds. Clinical diagnoses depend on patient and informant reports and are suspected of being susceptible to unintended bias. Diagnos…
View article: Can LLMs Address Mental Health Questions? A Comparison with Human Therapists
Can LLMs Address Mental Health Questions? A Comparison with Human Therapists Open
Limited access to mental health care has motivated the use of digital tools and conversational agents powered by large language models (LLMs), yet their quality and reception remain unclear. We present a study comparing therapist-written r…
View article: Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes
Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes Open
View article: Exposotypes in psychotic disorders
Exposotypes in psychotic disorders Open
View article: Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study
Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study Open
View article: Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum
Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum Open
Background Approximately 50% of individuals with psychosis spectrum disorders (PSD) experience visual hallucinations and deficits in visual processing. Cerebral blood flow (CBF) alterations have been identified in the occipital lobe (OL) a…
View article: Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues
Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues Open
View article: White Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits
White Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits Open
Aim This study aimed to evaluate associations in bipolar disorder (BD) across multimodal measures of white matter microstructure (using diffusion tensor imaging; DTI), cognitive, behavioral, and brain electrophysiological measures (using e…
View article: Exposotypes in Psychotic Disorders
Exposotypes in Psychotic Disorders Open
Psychiatry lags in adopting etiological approaches to diagnosis, prognosis, and outcome prediction compared to the rest of medicine. Etiological factors such as childhood trauma (CHT), substance use (SU), and socioeconomic status (SES) sig…
View article: Neuroanatomical Deficits in Visual Cortex Subregions of Individuals with Psychosis Spectrum Disorders linked to Symptoms, Cognition, and Childhood Trauma
Neuroanatomical Deficits in Visual Cortex Subregions of Individuals with Psychosis Spectrum Disorders linked to Symptoms, Cognition, and Childhood Trauma Open
Objective The visual system is a significant site of pathology in psychosis spectrum disorders. However, there is limited research investigating human visual cortex (VC) subregions in this population. Using data from the Bipolar-Schizophre…
View article: Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2
Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2 Open
View article: Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations
Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations Open
The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample. These Biotypes cut across DSM diagnoses of schizophrenia, schizoaffective d…
View article: Pons-to-Cerebellum Hypoconnectivity Along the Psychosis Spectrum and Associations With Sensory Prediction and Hallucinations in Schizophrenia
Pons-to-Cerebellum Hypoconnectivity Along the Psychosis Spectrum and Associations With Sensory Prediction and Hallucinations in Schizophrenia Open
Deficient pons-to-cerebellum connectivity linked sensory prediction network breakdowns with perceptual abnormalities in schizophrenia. Findings highlight shared features and clinical heterogeneity across the psychosis spectrum.
View article: Differentiating Biomarker Features and Familial Characteristicsof B-SNIP Psychosis Biotypes
Differentiating Biomarker Features and Familial Characteristicsof B-SNIP Psychosis Biotypes Open
View article: ACNP 62nd Annual Meeting: Poster Abstracts P501 – P753
ACNP 62nd Annual Meeting: Poster Abstracts P501 – P753 Open
View article: Clinical characterization and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT)-1
Clinical characterization and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT)-1 Open
View article: Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis
Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis Open
View article: Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men
Stimulant-like subjective effects of alcohol are not related to resting-state connectivity in healthy men Open
Individual differences in subjective, stimulant-like effects of alcohol are associated with the risk of developing alcohol use disorder. Specifically, individuals who experience more pronounced stimulant-like effects from alcohol are more …
View article: Emotional scene processing in biotypes of psychosis
Emotional scene processing in biotypes of psychosis Open
View article: Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders
Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders Open
View article: Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task
Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task Open
Stimulants like methamphetamine (MA) affect motivated behaviors via actions on circuits mediating mood, attention, and reward. Few studies examined the effects of single doses of stimulants on reward circuits during anticipation and receip…
View article: Monoallelic and biallelic mutations in<i>RELN</i>underlie a graded series of neurodevelopmental disorders
Monoallelic and biallelic mutations in<i>RELN</i>underlie a graded series of neurodevelopmental disorders Open
Reelin, a large extracellular protein, plays several critical roles in brain development and function. It is encoded by RELN, first identified as the gene disrupted in the reeler mouse, a classic neurological mutant exhibiting ataxia, trem…
View article: Characterization of Childhood Trauma, Hippocampal Mediation and Cannabis Use in a Large Dataset of Psychosis and Non-Psychosis Individuals
Characterization of Childhood Trauma, Hippocampal Mediation and Cannabis Use in a Large Dataset of Psychosis and Non-Psychosis Individuals Open
Background Cannabis use (CA) and childhood trauma (CT) independently increase the risk of earlier psychosis onset; but their interaction in relation to psychosis risk and association with endocannabinoid-receptor rich brain regions, i.e. t…
View article: Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders
Inflammation subtypes in psychosis and their relationships with genetic risk for psychiatric and cardiometabolic disorders Open
View article: Neuronal responses in social-emotional information processing in impulsive aggressive individuals
Neuronal responses in social-emotional information processing in impulsive aggressive individuals Open
View article: A subtype of institutionalized patients with schizophrenia characterized by pronounced subcortical and cognitive deficits
A subtype of institutionalized patients with schizophrenia characterized by pronounced subcortical and cognitive deficits Open
View article: What can clozapine’s effect on neural oscillations tell us about its therapeutic effects? A scoping review and synthesis
What can clozapine’s effect on neural oscillations tell us about its therapeutic effects? A scoping review and synthesis Open
View article: Real-time facial emotion recognition deficits across the psychosis spectrum: A B-SNIP Study
Real-time facial emotion recognition deficits across the psychosis spectrum: A B-SNIP Study Open